báo cáo khoa học: "The frequency of NPM1 mutations in childhood acute myeloid leukemia" doc

... [20]. In the current study, no NPM1 mutations were detected in cases with secondary AML following MDS, which is in line with previous s tudies associating absence or low rates of NPM1 mutations in ... assess the incidence and prognostic relevance of NPM1 mutations in childhood AML. NPM1 mutations w ere found in patients with de novo AML M1 and M2 subtypes. No...

Ngày tải lên: 10/08/2014, 22:21

... interact with a number of functional groups, including the aromatic side chains of some amino acids, through a stacking mechanism [42]. The interaction of arginine with aromatic amino acids of aB-crystallin ... that aB-crystallin most likely employs various methods of binding (or binding modes) in order to prevent the aggregation of stressed proteins. Some of these binding mod...

Ngày tải lên: 18/02/2014, 16:20

... phosphorylation of proteins involved in the trafficking of the receptor, including c-Cbl, could account for its intracellular retention. By contrast, TDI mutations in the ECD or disruption of the termination ... Conversion of Lys650 into methionine in the TK2 domain induces hyperphosphorylation and marked intracellular retent- ion of the mutant receptor leading to phosphoryla...

Ngày tải lên: 19/02/2014, 00:20

... detected at the dimer interface of the models or in the surroundings of the hinge loop residues. Likewise, the models of nonex- changing and exchanging HHP-RNase were prepared start- ing from 1Z7X. ... strong, neutralizing action of the cytosolic RNase inhibitor (cRI), a 50-kDa protein containing 16 leu- cine-rich repeat motifs [7,8]. In fact, onconase from Rana pipiens eggs [9],...

Ngày tải lên: 19/02/2014, 06:20

... substrate binding process. This provides strong evidence that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 ... not the terminal trimming of N-glycans is involved in the regulation of the stability and trafficking of GAT1. It has been reported that a variety of molecular chaperones a...

Ngày tải lên: 19/02/2014, 17:20

... finding is that combining both kinds of metrics gives top performance according to ev- ery meta-evaluation criteria. In addition, our Com- bined System Test shows that, when training a combined ... Acceptable. In Proceedings of the Joint 21st International Conference on Com- putational Linguistics and the 44th Annual Meet- ing of the Association for Computational Linguistics (COLING-...

Ngày tải lên: 20/02/2014, 07:20

... using an * While the fragment of English used in PTQ is large enough to demonstrate the introduction of inconsistent information, it is viewed as not being large enough to permit interesting ... contain incomplete information and to have information added to the model. A dynamic model is a "good enough" approximation to an infinite model when it contains the finite sub...

Ngày tải lên: 21/02/2014, 20:20

... corresponding nodes in/ 3. The remaining nodes in 7 ~ have the constraints of the corresponding nodes in 7. Given p E dom(7), by Ibl(7,p) we refer to the label of the node addressed # in 7. Similarly, ... terminal and terminal symbols of Gw. This trans- forms the question of determining whether a symbol is useful into a reachibility question on the graph of Ma In pa...

Ngày tải lên: 22/02/2014, 10:20

... properties of the document containing the sentence and properties of the sentence itself. Regarding the former type, two features come into play: the relevance score of the document (from the IR engine) ... Association for Computational Linguistics The Role of Information Retrieval in Answering Complex Questions Jimmy Lin College of Information Studies Department of Computer Sci...

Ngày tải lên: 08/03/2014, 02:21

... n-best pars- ing and MaxEnt discriminative reranking. In Proceedings of the 43rd Annual Meeting of ACL, pages 173–180. E. Charniak. 2000. A maximum-entropy-inspired parser. In Proceedings of the 1st ... structure. In 6th International Conference on Computational Linguistics and Intelligent Text Process- ing (CICLing). K. Hollingshead, S. Fisher, and B. Roark. 2005. Comparing and c...

Ngày tải lên: 08/03/2014, 02:21