báo cáo khoa học: "Epigenetic modifications as key regulators of Waldenstrom’s Macroglobulinemia biology" pot

... WM cells, as demonstrated by an increased % of cells in G1-phase, together with a decreased % of cells in S-phase. These findings were validatedatgeneexpressionprofilingthatshowed increased expression ... expression of cyclin-dependent kinase inhibi- tors (p18, p19, p21, p27); decreased expression of cyclin-dep enden t kinases-2, -4, -6, as well as cy clins D1, D2, D3 and E; and...

Ngày tải lên: 10/08/2014, 22:21

... inhibitors. Influence of ER a1,2-mannosidase I inhibition on ER exit of amino acid-substituted ASAs In order to investigate whether stabilization of mutant ASAs through inhibition of ER a1,2-mannosidase I via ... glucosidase and mannosidase inhibi- tion on the mutant ASAs (Gly86Asp, Tyr201Cys, Asp335Val, Pro136Leu, Asp255His, Thr274Met). In these experiments all of the mutant ASAs be...

Ngày tải lên: 07/03/2014, 17:20

... does not match the assumptions of kinetic models based on Michaelis–Menten kinetics [13,14,20]. After an initial phase of adsorption of cellulases on cellulose, which is fast compared to hydrolysis ... are a source of discrepancies in the results obtained and the potential confusion regarding the challenging problem of understanding the mode of action of cellu- lase [35]. The pr...

Ngày tải lên: 15/03/2014, 10:20

... percentage of the available words to ob- tain the same classification accuracy as with the full feature set, even in high-accuracy cases such as PBA and BL. The effectiveness of a small subset of features ... Consolidation of perspective We explore feature redundancy in perspective classification.We first investigate retention of only N best features, then elimination thereof. As...

Ngày tải lên: 17/03/2014, 00:20

... initial phase of myofibril disassembly, and the ubiquitin ⁄ proteasome system is in charge of the degradation of proteins that are no longer needed [49,62,63]. Interestingly, the recovery phase subsequent to ... reminiscent of the het- erodimeric structure of the ubiquitous calpains, the large subunits of which associate with a small subunit of 30 kDa [18]. It has been suggested...

Ngày tải lên: 23/03/2014, 10:21

... Third- to fifth-passage cells from human RPE were cultured with TPEN. Leakage of LDH into the medium was measured as a marker of RPE cell damage. Activity of calpains was assessed by casein zymography, ... initiation of the C3 convertase complex. Masp-3 is a splice variant of Masp-1, which has the same N- terminal domain structure of Masp-1 but a different serine protease domain....

Ngày tải lên: 23/03/2014, 15:20

... prerequisite, and this was also true in our patient’s case. But, while excessive vomiting in almost all other cases was sponta- neous and, except for one rep orted case [13], was inde- pendent of any elective ... first translation of the classic report of rupture of the esophagus with annotations. Bull Med Libr Assoc 1955, 43:217-239. 2. Weiss S, Mallory GK: Lesions of the cardiac o...

Ngày tải lên: 10/08/2014, 22:20

... the disease has been reported in the literature [8]. In the present case, the disease was diagnosed in a woman whose age was below the range reported for t he disease. Our patient was a dentist ... same aspects as shown in B and C at 400× magnification. Oliveira Alves et al. Journal of Medical Case Reports 2011, 5:406 http://www.jmedicalcasereports.com/content/5/1/406 Page 2 of 3 CAS E...

Ngày tải lên: 10/08/2014, 23:20

... 4:307 http://www.jmedicalcasereports.com/content/4/1/307 Page 4 of 4 CAS E REP O R T Open Access Elevated transaminases as a predictor of coma in a patient with anorexia nervosa: a case report and review of the ... papillary mydriasis or miosis. Her body temperature was 35.6°C. Therewerenosignsofrespiratoryorcardiacdisease. Her blood sugar level was 68 at the time of admission, in t...

Ngày tải lên: 11/08/2014, 02:21

... Moreover, both of our cases had a past history of lymph node tuberculosis, with evidence of the puckered scars of healed sinuses in their inguinal regions. The etiology in both of our cases was the extensive ... elephantiasis as a consequence of extensive lymph node destruction by tuberculosis in the inguinal region is rar er still. Sharma et al. reported two cases of vulval e...

Ngày tải lên: 11/08/2014, 02:22