báo cáo khoa học: "The clinical potential of microRNAs" docx

... utility of microRNAs for the diagnosis of cancer [37,38]. microRNA expres- sion profiles have been used to distinguish tumor from normal samples, identification of tissue of origin for tumors of unknown ... Moreover, the potential application of microRNAs in clinical settings will also be highlighted. Finally, the challenges regarding the translation of research involving mi...

Ngày tải lên: 10/08/2014, 22:21

... to investigate the clinical value of daily routine CXRs in critically ill patients. We showed not only that the incidence of potentially clinically relevant Table 3 Incidence of new expected and ... and malposition of the orotracheal tube (32 in 26). Fewer than half of the CXRs with a new and unexpected finding were ultimately clinically relevant; in only 2.2% of all daily routi...

Ngày tải lên: 25/10/2012, 10:39

... and outcome. In the case of hypoadreno- corticism, a combination of clinical signs, clinical chemistry profiles, and the value of an adrenocorticotropin (ACTH) stimu- lation test was used for ... information on clinical decision- making in some diseases. Traditionally, the differential diagnosis of electrolyte disorders has been framed in terms of pathophysiology, and the anal...

Ngày tải lên: 07/08/2014, 14:23

... (2/50) comprised of 6% of cases and 4% of cases, respectively. Our control group of IDCs was comprised of 100 age-matched cases. The ages ranged from 31 to 90, with an average age of 59.07 years. ... behavior of the ILC, the initial diagnostic workup has often involved the use of bilateral breast MRI to assess the state of the contralateral breast. The molecular characteriza...

Ngày tải lên: 09/08/2014, 03:21

... Moreover, orientation of the CDE ⁄ CHR in the general context of a promoter appears to be rele- vant because inversion of the site in the human Cdc25C promoter resulted in a deregulation of cell cycle-dependent ... determine a role of NF-Y in their control, a number of such genes were implicated to be regulated through CCAAT-boxes. Cotransfection of dominant-negative NF-YA demon...

Ngày tải lên: 16/02/2014, 09:20

... indicate that poly- merization of Gag occurs mainly through the forma- tion of an intermediate layer of cup-shaped structures, each made of one hollow hexameric ring of CA domains placed immediately ... of the precise residues and interac- tions involved in the NTD–CTD interface [46]. Most of these involve side chains from helix 8 of the CTD which pack against the N-terminal e...

Ngày tải lên: 18/02/2014, 06:20

... ring of CAP-1 inserts; the urea and dimethyla- monium groups of CAP-1 also make contacts with the side chains and ⁄ or backbones of several residues in the protein. Thus, most of the contacts of ... shifts of the whole dimer- ization helix of CTD [27] (otherwise, those chemical shifts are too broad to be observed because of the presence of interconverting conformers) [29]. T...

Ngày tải lên: 18/02/2014, 06:20

... biological function of the pro-form of bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor b (TGFb) ⁄ BLP superfamily. The role of the 263 amino acids of the pro-peptide ... experi- ments demonstrate binding of proBMP-2 to the ECD of BMPR-IA. Interaction of BMP-2 (A) and proBMP-2 (B) with immobilized ECD of BMPR-IA. Interaction of BMP-2 (C) and...

Ngày tải lên: 18/02/2014, 06:20

... structure of hACMSD in complex with DHAP may used for the design of potent and highly selective enzyme inhibitors that may prove to be of potential interest to reduce life-threatening complications of cerebral ... ccp 4 suite of programs [39] was used for scaling. Structure deter- mination for hACMSD was performed by means of the molecular replacement technique, using the coordi...

Ngày tải lên: 18/02/2014, 06:20

... 100 lm of (GlcNAc) 1–4 was analysed at the start, in the middle and at the end of each series of sam- ples. The resulting average values of the standards (display- ing standard deviations of < ... 4MU-(GlcNAc) 2 as substrate; 50 lL of supernatant was mixed with 50 lLof 50 mm citrate–phosphate buffer, pH 3.8, containing 50 lm of substrate and 0.1 mgÆmL )1 of bovine serum alb...

Ngày tải lên: 18/02/2014, 08:20