báo cáo khoa học: "Cytostatic and anti-angiogenic effects of temsirolimus in refractory mantle cell lymphoma" docx

... cytogenetic abnormalities of MCL, juxtaposes genes of cyclin D1 and of immunoglobulin heavy chain, inducing cyclin D1 over-expression and cell cycle deregulation [1]. Thus, cyclin D1 over-expression and/ or the ... analyses before and after temsirolimus showed the direct cyto- static effect of this mTOR inhibitor through cell cycle arrest, as demonstrated by down-regulati...

Ngày tải lên: 10/08/2014, 22:21

... 5 The expression of the proteins p-Akt, PTEN and PHLPP2 in Z138c-TMP2 and Z138c-miRNA-17-92 cells after radiation.The protein expression of pAkt, PTEN and PHLPP2 in both cell lines was detected ... 10:RA235-241. 18. Kandasamy K, Srivastava RK: Role of the phosphatidylinositol 3’-kinase/ PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis- inducing ligand-ind...

Ngày tải lên: 09/08/2014, 09:20

... out at intervals of 30° for each torsion angle /, h,andw and were subsequently refined by varying /, w angles in intervals of 10° and setting h angle to ) 60 ± 10° and 60 ± 10°.Each/, h,andw-value ... within the specific NK-1m binding site. The CH 2 b of the pyrrolidine ring of [Pro9]SP probably fits within this hydrophobic subsite and thus compensates destabilizing interaction...

Ngày tải lên: 08/03/2014, 08:20

... histopathological lesions in the seminiferous tubules. There were thickening and multiple layering of the tubular endothelium, and the formation of many multinucleated giant cells in seminiferous tubules. ... Thickening and multiple layering of the tubular endothelium (arrow), and the formation of many multinucleated gian t cells (arrow heads) in seminiferous tubules. H...

Ngày tải lên: 07/08/2014, 18:21

... immediately and fixed in 10% buffered formalin for 24 h, processed in an alcohol-xylene series, embedded in paraffin wax, and sectioned at 2 µm. The sections were stained with hematoxylin and eosin. ... 75% contained fat droplets. Inflammation was graded 0 to 3, as previously described [11]: 1 indicated the presence of scattered inflammatory cells, 2 indicated the presenc...

Ngày tải lên: 07/08/2014, 20:23

... G: The effect of intensive flunixin treatment during the postpartum period in the bovine. Journal of Veterinary Medicine A 1993, 40, 561-568. Odensvik K: Pharmacokinetics of flunixin and its ef- fect ... routes of ad- ministration (Kruskal-Wallis, p >0.05). Discussion In this study we have investigated the pharma- cokinetics of flunixin and its ability to inhibit of prosta...

Ngày tải lên: 12/08/2014, 15:20

... of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248–254. 27 Spiro R (1966) Analysis of sugar found in glycopro- teins. Methods Enzymol 256, ... cycles of denaturating at 94 °C for 1 min, primer anneal- ing at 55 °C for 1 min, and extension at 72 °C for 3 min. The PCR product (500 kbp) was isolated and ligated into the EcoRI-l...

Ngày tải lên: 30/03/2014, 01:20

... Effect of pyrogen induced fever on the pharmacokinetics of cefazolin in goats. Indian J Pharmacol 1992. 24,51. 15. Saini SPS. Effect of fever on pharmacokinetics and dosage regimen of amikacin in ... Schentag JJ. Clinical use of ceftriaxone: A pharmacokinetic- pharmacodynamic perspective on the impact of minimum inhibitory concentration and serum protein binding. Clin Pha...

Ngày tải lên: 07/08/2014, 18:21

... possible in vivo effect of Rituximab on the apoptosis of PBMNCs in the patients included in this study. Interestingly, we found an important and significant increase in the percent of TUNEL+ cells ... effective B cell depleting agent in vivo, inducing the lysis of these cells mediated by complement and by Fc receptor-bearing cyto- toxic cells as well as by inducing the...

Ngày tải lên: 09/08/2014, 08:22

... phase syndrome: clinical and investigative findings in 14 subjects. J Neurol Neurosurg Psychiatry 1992, 55:665-670. 39. Tzischinsky O, Dagan Y, Lavie P: The effects of melatonin on the timing of sleep in patients ... blood melatonin in patients with insomnia than in healthy controls, and Haimov et al [31] found lower levels of urinary 6-sulpha- toxymelatonin in elderly p...

Ngày tải lên: 10/08/2014, 09:20