báo cáo khoa học: "Mechanism of action of lenalidomide in hematological malignancies" pptx

... topic. Opinion-target pairs are identified using a number of hand-crafted rules. The functionality of this system is based on our previous work on attitude mining and subgroup detection in online discussions. This ... related to previous work in the areas of sentiment analysis and online discussion mining. Many previous systems studied the problem of iden- 133 Figure 2: A screensho...

Ngày tải lên: 16/03/2014, 20:20

... results in the highest gain in F-value for the combined model on the training set is appended to the list. The algorithm terminates when F-value cannot be improved by any of the remaining candidates. ... In Proceedings of the IJCAI-95, pages 1420–1425, Montreal. John T. Maxwell III and Ronald M. Kaplan. 1989. An overview of disjunctive constraint satisfaction. In Pro- ceedings...

Ngày tải lên: 17/03/2014, 06:20

... subset of the states of ˆ G. When computing the outgoing transitions of the states in (s 1 , s 2 ) with input label a, the backoff transitions of a state s 2 are inspected if and only if none of ... large. 2 Instead, we restricted the inspection of the backoff states in the following way within the composition p ◦ ˆ G. A state s 1 in p corresponds in the composed transduce...

Ngày tải lên: 23/03/2014, 19:20

... effects of genes and allelic interaction effects within and between loci justifies the use of a multifactorial model. Furthermore, the assumption of an infinite number of loci ... assumptions of random mating and linkage equilibrium. The case of linked loci was investigated later by Cockerham [6] and Schnell (36!. The case of inbred rela...

Ngày tải lên: 09/08/2014, 18:21

... expression of the set of the genes Mechanism of action of lenalidomideFigure 3 Mechanism of action of lenalidomide. Various mechanisms by which lenalidomide achieves clinical efficacy in hematologi- cal ... purposes) apoptosis in MM cell lines[35]. Effects on apoptosis in MM cells is secondary to increased potentiation of TNF related Apoptosis inducing ligand (TRAIL...

Ngày tải lên: 10/08/2014, 22:20

... subsites of Erv-C with Leu23 in the S2 pocket, considering the specificity of Erv-C towards a Leu residue [17]. The mode of interactions of mini-chain of human lyso- somal cysteine protease cathepsin ... residues of Erv-C mature domain within 4.2 A ˚ (C atoms are shown in deep bottle green). Interdomain distances within 4.2 A ˚ are shown in green. Role of C-terminal extensi...

Ngày tải lên: 14/02/2014, 14:20

... DHNA inhibitors. The binding of the inhibitors to the enzymes cause a decrease in their fluorescence intensities. The increasing fluorescence intensities in Fig. 5A were obtained by subtracting ... measured the binding of HP in the absence of GA. NP and MP are the oxidized forms of the pterins, with a double bond between C7 and N8 instead of a single bond as in the reduced pte...

Ngày tải lên: 19/02/2014, 00:20

... units, which often contain sugar side chains composed of arabinan and galactan [1]. Degradation of the pectin polymer occurs via a set of pectinolytic enzymes, which can roughly be divided into esterases, ... be classified into lyases (b-elimination) and hydrolases [2]. All hydrolases involved in degradation of pectin are classified as members of family 28 of the glycoside hydrola...

Ngày tải lên: 20/02/2014, 03:20

... peroxidase–oxidase reaction by the addition of a small amount of hydroquinone [28]. In this case we observe an abrupt termination of the degradation of the enzyme [12], because the inhibition of the reaction ... generated during the reaction [13,29,30]. A further understanding of the mechanism for inactiva- tion of the enzyme may come from measurement of the effect of the...

Ngày tải lên: 20/02/2014, 11:20

... underlining was not present in the experimental items.) The amount of inferencing required to process the relative target was manipulated by changing the (underlined) wording in the preceding ... suspicious of& quot; ("inferencing") to "had his doubts about" ("minimal inferencing"). Apart from finding strong effects of context (thereby replicati...

Ngày tải lên: 22/02/2014, 09:20