báo cáo khoa học: "Vorinostat in solid and hematologic malignancies" potx

... metastases and other indications whereradiotherapy is used alone and in combination.On the basis of these and other studies, vorinostat in com-bination is being evaluated in clinical trials in patientswith ... lungcancer, and NSCLC, and Phase II studies in combinationwith tamoxifen or carboplatin and paclitaxel in patientswith advanced breast cancer or in combination with car-boplatin and paclitaxel in patients ... ofheat-shock protein 90 [10], and in the formation of aggre-somes of ubiquitinylated proteins [11].Vorinostat Monotherapy for Solid and Hematologic MalignanciesVorinostat is the first HDAC inhibitor...

Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

... modulated by lumican-evoked signaling,including vinculin and focal adhesion kinase [82].Lumican alters the relationship between actin ﬁlaments and b1 integrin, which in turn would affect focal adhe-sion ... with the EGF-binding domain [32]. Thestructural constraints of the EGFR binding regionsupport a stochiometry of 1 : 1 for the decorin pro-tein core and EGFR, suggesting that decorin is bio-logically ... explaining the anti-invasiveeffects of this SLRP [82]. A commonality of signalingbetween lumican and decorin is also supported byrecent studies showing the involvement of decorin in modulating...

Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

... HEXXHXXGXXH) and a conserved methionine(Met-turn) supporting the catalytic zinc. Interactionbetween cysteine–zinc maintains proMMPs in an inac-tive state by preventing a water molecule from bindingto ... (GAIP)-interacting C-terminus ⁄synectin and calc ium ⁄ calmodulin-associated serine kinase,since the C2 region contains a class II PSD-95 ⁄Discs-large ⁄ Zonula occludens protein-binding motifFXF, ... (Pro) containing a cysteine switch motifPRCGXPD (except for MMP23 which lacks thecysteine switch motif) that maintains them as inactivezymogens, and a catalytic domain with a z inc-binding site(Zn,...

Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx

... Accumulating evidences indicate thatHSPGs act to inhibit cellular invasion by promotingtight cell–cell and cell–ECM interactions, and by main-taining the structural integrity and self-assembly ... in lungcarcinoma and chronic myeloid leukemia comparedwith control tissue and cells. In this splice variant,144 bp of intron 5 are joined with exon 4, resulting in a 169-amino-acids protein ... theseemingly distinct protein domains observed in the 3Dmodel, namely the TIM-barrel and C-domain regions,mediate enzymatic and nonenzymatic functions of hep-aranase, respectively. Interestingly,...

Báo cáo khoa học: "Asymmetry in Parsing and Generating with Unification Grammars: Case Studies From ELU" pot

... been employed successfully in general, mJking it possible to envisage defining the 'ade- quacy' of a grammar in terms of its behavior both in parsing and in generation. References ... between parsing and generating lies in the nature of the input. The text, as a string of words, traditionally establishes the starting point of parsing; whether the processing is top-down ... In German and Dutch, there are two positions in a sentence where tensed verbs may appear: in second position of a main clause, and in final position of a subordinate clause. Once again, a multitude...

Báo cáo khoa học: "Modeling Inﬂection and Word-Formation in SMT" doc

... their POS tags in the input. Verbs are in ected in the input (“haben”, meaning“have” as in “they have”, in the example). Prepositions are lexicalized (“zu” in the example) and indicate whichcase ... al’ssystem might generate the “stem and in ection”corresponding to and his brother. Viewing and and his as in ection is problematic since a map-ping from the English phrase and his brother tothe Arabic ... Computational Linguistics.Maja Popovic, Daniel Stein, and Hermann Ney. 2006.Statistical Machine Translation of German Com-pound Words. In Proceedings of FINTAL-06, pages616–624, Turku, Finland. Springer...

BÁO CÁO KHOA HỌC " Changes in microbial and postharvest quality of shiitake mushroom (Lentinus edodes) treated with chitosan–glucose complex coating under cold storage " pptx

... coating might be a promisingcandidate for maintaining shiitake mushroom quality and extending its postharvest life.Ó 2011 Elsevier Ltd. All rights reserved.1. IntroductionShiitake (Lentinus ... mechanical injuries, as well as sealing smallwounds and thus delaying dehydration. Chitosan coatings havebeen effective at controlling water loss from some commodities,including cucumber, pepper and ... delayed changes in the ascorbic acid and soluble solids concentration during thestorage period. These results suggest that CGC is promising as anedible coating to be used for maintaining shiitake...

Báo cáo khoa học: "Haemostatics in surgery and our experience in the enucleoresection of renal cell carcinoma" ppt

... purified porcine skin gelatin [1]. The haemostaticefficacy and handling of gelatin-thrombin matrix hasbeen proven also in the uterine bleeding, during abdomi-nal myomectomy and, in thyroid surgery ... HAs composed of a gelatin-based matrix and throm-bin have been reported to be effective, in addition totraditional means, in terminating bleeding during cardiacoperations in comparison with haemostatic ... way of achieving hae-mostasis considering the satisfying results, their handling and their efficacy, in the enucleoresecton of RCC lookingto a further employ also in the nerve sparing RRP. Never-theless,...

Báo cáo khoa học: "Dysphagia in head and neck cancer patients following intensity modulated radiotherapy (IMRT)" pptx

... swallowing structures not involved bytumor and not at risk of subclinical disease. In addition, in a previous evaluation of our hypopharynx-larynxpatient cohort [22] treated with IMRT using midlinesparing ... anatomical swallowing structureswas routinely perfor med by dr awing a laryngo -pharyn-geal midline ‘shielding’ contour outside the PTVs in allcases. This s paring structure has been defined prospec-tively ... observer-assessed instruments. Patient-reportedclinical swallowing function was evaluated using the“European Organi zation for Research and Tre atment ofCancer (EORTC) head -and- neck 35-item swallowingand...

báo cáo khoa học: "Challenges in clinical and laboratory diagnosis of androgen insensitivity syndrome: a case report" ppt

... domains. The AR is characterizedby a modular structure consisting of four functionaldomains: an N-terminal domain (NTD), a DNA-bindingdomain (DBD), a hinge region, and a ligand-bindingdomain ... Androgen Receptor Ligand BindingDomain with the N-terminal Domain and with Coactivators. In AndrogenAction in Prostate Cancer. Edited by: Tindal D, Mohle. New York, USA:Springer Science; 2009:375-384.6. ... manuscript. DMS was involved in collatinginformation regarding the case and getting informed consent from ourpatient. ADC was involved in the review of literature and revising themanuscript...

Xem thêm