báo cáo khoa học: "Vorinostat in solid and hematologic malignancies" potx

... metastases and other indications where radiotherapy is used alone and in combination. On the basis of these and other studies, vorinostat in com- bination is being evaluated in clinical trials in patients with ... lung cancer, and NSCLC, and Phase II studies in combination with tamoxifen or carboplatin and paclitaxel in patients with advanced breast cancer or in comb...

Ngày tải lên: 10/08/2014, 22:20

... modulated by lumican-evoked signaling, including vinculin and focal adhesion kinase [82]. Lumican alters the relationship between actin filaments and b1 integrin, which in turn would affect focal adhe- sion ... with the EGF-binding domain [32]. The structural constraints of the EGFR binding region support a stochiometry of 1 : 1 for the decorin pro- tein core and EGFR, suggesting that...

Ngày tải lên: 15/03/2014, 23:20

... HEXXHXXGXXH) and a conserved methionine (Met-turn) supporting the catalytic zinc. Interaction between cysteine–zinc maintains proMMPs in an inac- tive state by preventing a water molecule from binding to ... (GAIP)-interacting C-terminus ⁄ synectin and calc ium ⁄ calmodulin-associated serine kinase, since the C2 region contains a class II PSD-95 ⁄ Discs-large ⁄ Zonula occludens protein-...

Ngày tải lên: 15/03/2014, 23:20

... Accumulating evidences indicate that HSPGs act to inhibit cellular invasion by promoting tight cell–cell and cell–ECM interactions, and by main- taining the structural integrity and self-assembly ... in lung carcinoma and chronic myeloid leukemia compared with control tissue and cells. In this splice variant, 144 bp of intron 5 are joined with exon 4, resulting in a 169-amino-...

Ngày tải lên: 15/03/2014, 23:20

... been employed successfully in general, mJking it possible to envisage defining the 'ade- quacy' of a grammar in terms of its behavior both in parsing and in generation. References ... between parsing and generating lies in the nature of the input. The text, as a string of words, traditionally establishes the starting point of parsing; whether the processing...

Ngày tải lên: 24/03/2014, 02:20

... their POS tags in the input. Verbs are in ected in the input (“haben”, meaning “have” as in “they have”, in the example). Prepositions are lexicalized (“zu” in the example) and indicate which case ... al’s system might generate the “stem and in ection” corresponding to and his brother. Viewing and and his as in ection is problematic since a map- ping from the English phra...

Ngày tải lên: 24/03/2014, 03:20

... coating might be a promising candidate for maintaining shiitake mushroom quality and extending its postharvest life. Ó 2011 Elsevier Ltd. All rights reserved. 1. Introduction Shiitake (Lentinus ... mechanical injuries, as well as sealing small wounds and thus delaying dehydration. Chitosan coatings have been effective at controlling water loss from some commodities, including cucumber, pe...

Ngày tải lên: 28/06/2014, 11:20

... purified porcine skin gelatin [1]. The haemostatic efficacy and handling of gelatin-thrombin matrix has been proven also in the uterine bleeding, during abdomi- nal myomectomy and, in thyroid surgery ... HAs composed of a gelatin-based matrix and throm- bin have been reported to be effective, in addition to traditional means, in terminating bleeding during cardiac operations in...

Ngày tải lên: 09/08/2014, 03:21

... swallowing structures not involved by tumor and not at risk of subclinical disease. In addition, in a previous evaluation of our hypopharynx-larynx patient cohort [22] treated with IMRT using midline sparing ... anatomical swallowing structures was routinely perfor med by dr awing a laryngo -pharyn- geal midline ‘shielding’ contour outside the PTVs in all cases. This s paring structur...

Ngày tải lên: 09/08/2014, 09:20

... domains. The AR is characterized by a modular structure consisting of four functional domains: an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region, and a ligand-binding domain ... Androgen Receptor Ligand Binding Domain with the N-terminal Domain and with Coactivators. In Androgen Action in Prostate Cancer. Edited by: Tindal D, Mohle. New York, USA: Springer Science...

Ngày tải lên: 10/08/2014, 23:20