báo cáo khoa học: "RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression" doc

... in CML blast crisis is not known. One possible explanation is that the RIZ1 promoter CpG island is aberrantly hypermethyl- ated. In the CML blast crisis cell line, K562, the RIZ1 pro- moter is ... previous observations that a putative CML tumor suppressor gene is present at 1p36 that exhibits loss of heterozygosity during transformation from chronic phase to blast...

Ngày tải lên: 10/08/2014, 22:20

... week. Statistical analyses For statistical analysis, overall (OS) survival of patient was determined from the time of initial diagnosis until death from any cause or to last follow-up. Disease- free ... growth pattern. This tumor achieved a surface area of 3.5 cm 2 within 15 weeks. Sur- vival of this T-ALL patient was less than 6 months after his relapse. In vivo propagation potential o...

Ngày tải lên: 10/08/2014, 22:20

... the tissues producing it. In response to tissue injury, such as hepatic and renal injury, the inactive single-chain HGF is converted to a two-chain form exclusively in the injured tissue. This ... by HAI-1–NK1 (Fig. 4C), suggesting that HAI-1 functions as a regulator for the activation of HGF in injured tissues. RT-PCR analysis showed that TMPRSS13 mRNA is co-expressed with HAI-1 mRNA...

Ngày tải lên: 15/02/2014, 01:20

... adipocytes to resist apoptosis, adipocyte apoptosis is much less studied and is poorly understood. Recently, evidence from several in vivo and in vitro studies has indicated that apoptosis is a significant ... depletion during weight reduction [5–8]. In addition, an animal model of adipocyte apoptosis has been developed as a tool for the study of obesity-related diseases [9]. Adipocy...

Ngày tải lên: 16/02/2014, 09:20

... is shorter with respect to that of the two homologous proteins whose structure has been determined: its volume is 151 A ˚ 3 , whereas that of the T. thermophilus protein is 233 A ˚ 3 . This is ... The evidence that the pro- tein is secreted, coupled with the fact that the stom- ach mucosa, where H. pylori establishes persistent colonization and causes chronic inflammation, i...

Ngày tải lên: 16/02/2014, 14:20

... subunit is essential for the function of this subunit as a chaperone and that binding of I to D is not enough to maintain the D subunit in the cell. Our study suggests that ATP hydrolysis is important ... it is well-known that Mg 2+ is required to perform the ATP hydrolysis. In addition, kinetic analysis had shown binding of Mg 2+ to this subunit [21]. An integrin I domain, su...

Ngày tải lên: 19/02/2014, 12:20

... to Tyr232 only if Tyr230 is not glucosylated. Whilst the reason for this selective a-amylase action is unknown, it is useful for the generation of glucosylated peptides that are accessible to Fig. ... y using this m/z value a nd the data shown in Fig. 2 it is estimated t hat 4–25 glucosyl residues are covalently bound to P 1 . This implies that Glg2p i s significantly g lucosylated...

Ngày tải lên: 19/02/2014, 16:20

... pre- sented in this study suggest that this PRD is necessary for the inducible expression of fgl2, we plan to undertake additional studies aimed at more precisely elucidating specific mechanisms regulating ... affected basal expression of fgl2, it is possible that the nucleoprotein complexes that form upon this PRD cis region interact with the core transcription machinery that form...

Ngày tải lên: 20/02/2014, 11:20

... and 98 kDa (Fig. S2). SDS ⁄ PAGE analysis combined with activity assays confirmed that both peaks consist exclusively of CyrA. This indicated that CyrA is present in two forms, dimer and tetramer. Size ... and endo-LysC). Doc. S1. MS analysis of CyrA reaction sequence. This supplementary material can be found in the online version of this article. Please note: As a service to our author...

Ngày tải lên: 06/03/2014, 22:21

... the ISP sequences and the comparison group (Fig. 2). Both curves display a positive score in the h-region which corresponds to relative hydrophobicity. The data show that the ISP group is distinctly ... detectable; this confirms that practically no cell lysis occurred during extraction of the periplasm. The enzymatic activites of malate dehydrogenase and cytochrome c oxidase show that...

Ngày tải lên: 07/03/2014, 11:20