báo cáo khoa học: "New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer" doc

... are in various stages of clinical development for therapy of multiple cancer types. In this review we summarize novel histone deacetylase inhibitors and new regimens from clinical trials for epigenetic ... 11 (page number not for citation purposes) Journal of Hematology & Oncology Open Access Review New clinical developments in histone deacetylase...

Ngày tải lên: 10/08/2014, 22:20

... sensitization and in ammation in the respiratory tract and skin [5,6]. IL-13 has been shown to induce many of the features of EoE in human tissue and murine systems, including the induc- tion of CCL-26 ... prevalence of eosinophilic esophagitis Eosinophilic gastrointestinal diseases are increasingly recognized and diagnosed disorders that include eosino- philic esophagitis (Eo...

Ngày tải lên: 11/08/2014, 12:20

... ×20) offered an advantage in selecting more representative sites for biopsy than routine clinical examination alone. The next step is to obtain accurate microscopic assessment at the time of clinical ... staining The presence of numerous mitotic figures per field The presence of 2 or more stained nucleoli per cell suggesting aneuloploidy Tissue Level Punctate staining of cells...

Ngày tải lên: 11/08/2014, 23:22

... CA. Kevin Duh and Katrin Kirchhoff. 2008. Beyond log- linear models: Boosted minimum error rate training for n-best ranking. In Proceedings of the 46th Annual Meeting of the Association for Computational ... 2009. Efficient minimum error rate train- ing and minimum Bayes-risk decoding for translation hypergraphs and lattices. In Proceedings of the 47th Annual Meeting of the A...

Ngày tải lên: 19/02/2014, 19:20

... It is interesting to note in the WAT of C57 mice at 24 °C a significant level of expression of UCP1 mRNA reaching 3% of that observed in BAT. Our study shows for the first time that the lack of b 3 -adrenoceptor strongly ... Ten days of cold-exposure increased the number of multilocular cells and induced the expression of UCP1 in some of them in both WT and b 3 KO mi...

Ngày tải lên: 23/03/2014, 20:22

... used medicinally for centuries, predominantly in China [19]. A sesquiterpene constituent, artemisinin, is one of the most important drugs used in the treatment of malaria. In an effort to isolate ... primers for use in RT-PCR. Here, we describe the isolation of a b-amyrin synthase gene from A. annua and its expression in S. cerevisiae. Our findings on engineering overproduc...

Ngày tải lên: 30/03/2014, 04:20

... acquisition of data, or analysis and interpretation of data, involved in drafting the manuscript or revising it critically for important intellectual content. RP have been involved in drafting the ... chemotherapy, including FOLFOX in 35 patients, FOLFIRI in 15, Avastin in 37 patients, and other biologics in 9, with 2 patients receiving hepatic directed radiotherapy. The ext...

Ngày tải lên: 09/08/2014, 04:21

... collimation, tomotherapy and physical compensators. In July 2001 3D-conformal intensity modulated radiotherapy (3D-c- IMRT) using metallic compensators was introduced in clinical practice at this institution. ... Access Research 3D-conformal-intensity modulated radiotherapy with compensators for head and neck cancer: clinical results of normal tissue sparing ThomasGWendt* 1 , Na...

Ngày tải lên: 09/08/2014, 10:21

... u p for a minimum of five years from the date of surgery. Immunohistochemical Analysis Formalin fixed paraffin embedded (FFPE) lymph nodes recovered at s urgery were used for immunostaining. ... Germany) after manual drying. Heat induced epitope retrieval was performed using ER2 (Bond™)atpH9. 0for2 0minat 100°C. After blocking with 3% peroxide block for 5 min, the sections were incu...

Ngày tải lên: 10/08/2014, 10:21

... was involved in discussion of the manuscript; SS was supervisor of clinical management of the patient and interpretation of the data. All authors read and approved the final manuscript. Competing ... differentiate in the upper epidermal layers. In the case presented, the immunohis- tochemical analyses of EGFR protein revealed an intense membranous staining in the basal ker...

Ngày tải lên: 10/08/2014, 22:20