báo cáo khoa học: "First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting" pot

... tanciations of the variables in STRUCTU- RE can be obtained only by identifying (an operation intuitively similar to the standard notion of unification - again, see later in fig. 5) the STRUCTURE ... STCG. (Note that the rules with properties similar to the rule $2 entail a definition of direct derivation which is more complex than the classical definition). The se...

Ngày tải lên: 22/02/2014, 10:20

... motif and the SAM region have the potential to facilitate oligomerization, it is challenging to differ- entiate which region contributes to the oligomerization process. To overcome the limitations ... of investigating the Ca 2+ -binding sites in native Ca 2+ -binding proteins, we established a grafting approach to dissect their site- specific properties. This approach has been used...

Ngày tải lên: 07/03/2014, 00:20

... insulin-like growth factor-1 requires the induction of Sp1 protein [41]. In discussing the possi- ble implications of targeting Sp1 transcription factor(s) with transcription factor decoy oligonucleotides, ... previous studies showing that the transcription of other TATA- less promoters frequently involves the action of proxi- mal Sp1 sites [24,25]. The mapping of the in...

Ngày tải lên: 23/03/2014, 07:20

... purposes) Journal of Hematology & Oncology Open Access Review First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting Andrea ... successful inhibition of designated targets, these phase I trial results suggest potential for using biomarkers to help predict and monit...

Ngày tải lên: 10/08/2014, 22:20

... pragmatic interpretation. Each piece of information is a thresholding device with memory. It has an activity value, initially at a resting state, that is modified over time depending on the input, ... meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension is defined. The processes are independent of the...

Ngày tải lên: 21/02/2014, 20:20

... allows some vestige of compositionality to persist in the semantics, I think that at the very least a serious reconsideration of the BKPZ proposal is in order. IV. CONCLUSIONS It is of course ... Schemata in GPSG. In Proceedings of the Nineteenth Annual Meeting of the Association for Computational Linguistics. ACL, Stanford, CA. Also DAI Research Paper 165, Dep...

Ngày tải lên: 24/03/2014, 01:21

... nghiên cứu khoa học giữa Viện Chăn nu i v i Tiểu dự án II, tháng 8 năm 2007 các giống gà hướng trứng Zolo và Bor cũng ñược tiếp nhận. Viện ñã giao cho Trung tâm Thực nghiệm và Bảo tồn vật nu i ... di truyền của hai giống gà này, ñồng th i kết quả chiều ño cũng chứng minh cả hai giống gà có ñặc i m là các giống hướng trứng. Tỷ lệ nu i sống Kết quả t i bảng 4 ñã cho thấy ở TH3, hai...

Ngày tải lên: 28/06/2014, 02:20

... of a-defensins can also be found outside neutrophils in the fibrotic foci in the lungs of IPF patients [5,8]. In addition to potential antimicrobial effects, a-defensins in the lung tissue may ... fibroblasts. Inhibition of the b-catenin signaling pathway using quercetin blocked the a-defensin-induced increase in lung fibroblast proliferation and collagen synthesis To investigate...

Ngày tải lên: 18/02/2014, 06:20

... cofactor of the deaminase from strain 10d because the enzyme could not be purified in large enou gh quantities. We previously reported the identification of the enzyme involved in the initial step of the ... responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid in Bordetella sp. strain 10d Chika...

Ngày tải lên: 19/02/2014, 16:20

... acidified at pH 2.4. It is worth noting that at the end of the titration, even after addition of excess Cu (I) , some species still retained Zn(II) ions. The discussion of the Cu (I) coordination ... synthesized in the presence of supplemented Zn(II) or Cd(II). In CeMT2, the unique C-terminal histidine abolishes the Cu-thionein character that this isoform would otherwise...

Ngày tải lên: 07/03/2014, 02:20