báo cáo khoa học: "Novel therapies in breast cancer: what is new from ASCO 2008" ppsx

... awaiting data analysis.[11] It is also currently being evaluated in phase I/II studies in combina- tion with paclitaxel as well as in combination with vinor- elbine in patients with advanced breast ... anti- tumor activity for MBC in the first-line setting. Further studies using axitinib in breast cancer are ongoing. Topoisomerase II inhibitors C1311 C1311 is an inhibitor...

Ngày tải lên: 10/08/2014, 22:20

... results were disappointing in that the ORR and OS appear inferior to standard cisplatin-based regi- mens. Vinflunine Vinflunine is a novel vinca alkaloid that inhibits tubulin and acts to inhibit assembly ... most exciting findings in the field of prostate cancer is the recognition that persistent androgen signal- ing remains critical in CRPC. Approaches to targeting androgen signal...

Ngày tải lên: 10/08/2014, 22:20

... OGDH isoform and its implication in brain metabolism Distinguishing proteins with highly similar primary structures, such as the products of alternative splic- ing or of different genes (isoforms ... struc- ture–function analysis of protein–protein interactions in OGDHC and provide important insights into phys- iologically relevant issues. A more pronounced disso- ciation of the E3 compon...

Ngày tải lên: 23/03/2014, 06:20

... other fungi, including A. alternata IFO 6587, could not induce, or weakly induce chitinase activity. The purified elicitor was soluble in 75% methanol and showed the chitinase-inducing activity ... As an index of eli- citor activity, we measured the induction of TBC-1, a tobacco class IV chitinase homolog [14]. Interestingly, the activity of this isozyme increased remarkably following treatm...

Ngày tải lên: 23/03/2014, 11:20

... purposes) derline lesion on histology that is difficult to distinguish from low grade DCIS on the small tissue sample provided by CNB. Because of this difficulty, clinico-pathologic and radiologic findings ... Signifi- cant discordance has been reported isn CNB diagnosis of ADH, with 7%-87% of cases proving to be DCIS or inva- sive carcinoma on subsequent surgical excision [8-14]. This pr...

Ngày tải lên: 09/08/2014, 04:21

... survival in breast cancer? A meta-analysis. J Clin Oncol 2000, 18:1220-1229. 24. Sotiriou C, Wirapati P, Loi S, et al: Gene expression profiling in breast cancer: understanding the molecular basis ... At this time, the role of PMRT for women with 1 to 3 positive lymph nodes remains uncertain and is being examined in a rando- mized clinical trial”. Many surgeons and radiation onc...

Ngày tải lên: 09/08/2014, 09:20

... resistant phenotype is a major hurdle in curative cancer therapy approaches and many scientists around the world are focussing on this issue. This review covers new findings in this field during ... but also promising new idea is the use of PARP1 inhibitors as chemosensitisers in com- bination with Platinum-based chemotherapy. Preliminary results from clinical trials are promi...

Ngày tải lên: 10/08/2014, 10:21

... injury: radiation-induced fibrosis and necrosis. Semin Radiat Oncol 2007, 17:99-107. 7. Bedwinek JM, Fineberg B, Lee J, Ocwieza M: Analysis of failures fol- lowing local treatment of isolated local-regional ... course of radiation to the whole breast is used with caution as increased toxicity of skin and subcutaneous tissue is feared. Nevertheless, in recent years several investigator...

Ngày tải lên: 09/08/2014, 09:22

... DCIS 2.8 5 Invasive Invasive 9.6 6 Invasive Invasive 42.6 7 Invasive Invasive 55.1 8 Invasive Invasive 77.7 9 DCIS Invasive 83.2 10* Unknown DCIS 130.6 11 Invasive DCIS 197.1 Abbreviations: DCIS, ... contralateral breast cancers and time interval in- between in patients with bilateral disease Patient No First Second Interval (months) 1 DCIS Invasive 0.0 2 Invasive DCIS 0.0 3 DCIS Invas...

Ngày tải lên: 09/08/2014, 09:22

... looking at the effectiveness of Pirfenidone in ameliorating or treating established fibrosis resulting from radiation therapy. We initiated this pilot study to examine whether Pirfenidone, administered ... well as human in vitro studies to alter cytokine signaling and reduce or eliminate pulmonary inflamma- tion and fibrosis. Pirfenidone is currently being evaluated in phase 2 and 3...

Ngày tải lên: 09/08/2014, 10:21