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báo cáo khoa học: "Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma" pptx

báo cáo khoa học:

báo cáo khoa học: " All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein" pdf

... Peckham.Results and conclusion: In this work, for the first time we have demonstrated that ATRA affected on cell proliferation of GIST-T1 and GIST-882 cell line through inhibition of cell growth in a dose ... All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein. Journal of Experimental ... AccessAll-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromaltumor GIST-T1 cell line by affecting on theexpression of survivin and Bax proteinHoang Thanh...
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Tài liệu Báo cáo khoa học: Agrobacterium tumefaciens type II NADH dehydrogenase Characterization and interactions with bacterial and thylakoid membranes ppt

Tài liệu Báo cáo khoa học: Agrobacterium tumefaciens type II NADH dehydrogenase Characterization and interactions with bacterial and thylakoid membranes ppt

... proposed to be involved in theinteraction with hydrophobic quinones of respiratorychains [11,13]. Respective contributions of both hydro-phobic domains to membrane and quinone interactionsrequire ... King’s Lynn, UK). In some experiments, areaction mixture containing 10 lL of membranes of E. coliANN0222 and 1.5 lg of purified enzyme was preincubated10 min on ice, then diluted in 990 lL of ... a control, cells were plated on aLuria–Bertani agar medium containing ampicillin and appropriate IPTG concentrations and incubated at 37 °Covernight.Flavin analysisThe nature of the flavinic...
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Báo cáo khoa học: Human kynurenine aminotransferase II – reactivity with substrates and inhibitors potx

Báo cáo khoa học: Human kynurenine aminotransferase II – reactivity with substrates and inhibitors potx

... line) and 60 min (long dashed line) after the addition of CSA. (B) Determina-tion of the mechanism of inhibition. The inhibitory effect of CSA on KATII was determined by monitoring the rate of ... determined by moni-toring the formation of ammonia as a function of timefor a solution containing KATII, 8 mm ESBA, and 12 mm KG. The reaction was linear within 180 min,with a slope of 2.5 lmÆmin)1ammonia ... 3-NPA (f) and 2 mM OPS (g) in the presence of 2.2 lMKATII is shown in lines 7 and 8. In lines 9–12, each molecule wastested for inhibition of the transamination reaction in the presence of 10 mM...
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Báo cáo khoa học: Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (AriceptÒ) to cholinesterases doc

Báo cáo khoa học: Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (AriceptÒ) to cholinesterases doc

... thebinding of ligands such as huperzine A, edrophonium,acridines and one end of bisquaternary compounds such as BW284C51 and decamethonium [28,34,35] and destabilizesthe binding of phenothiazines ... series of indanone-benzylpiperidines synthesized by Eisai. Thesestudies elucidated the effect of substitutions on the benzyl and indanone rings of this class of inhibitors on theirinhibition potency ... alternate configurations [34]. The importance of gorge dimensions in accommodating bulky inhibitorswas also seen in the binding of propidium, decamethonium,tacrine and ethopropazine. The phenyl and...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "Organizing Encyclopedic Knowledge based on the Web and its Application to Question Answering" ppt

... of Web pages contain-ing the term, b) extraction of page fragments describ-ing the term, and c) organizing extracted descriptionsbased on domains (and consequently word senses). In addition, ... M. Tice. 2000. Buildinga question answering test collection. In Proceed-ings of the 23rd Annual International ACM SIGIRConference on Research and Development in Infor-mation Retrieval, pages ... metrics in centralized/distributed informa-tion retrieval on the World Wide Web. In Proceed-ings of the 23rd Annual International ACM SIGIRConference on Research and Development in Infor-mation...
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Báo cáo khoa học: A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles pdf

Báo cáo khoa học: A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles pdf

... activity of CatE and CatD was determined in subcellular fractions of different cell types using acombination of the peptide substrate, aspartic prote-inase inhibitor (pepstatin A) and depletion of ... activity.Western blot analysis of subcellular fractionsfrom different cell lines used for CatE and CatDdeterminationFor immunochemical determination of subcellularlocalization of CatE and CatD, western ... Distribution of TAPA, CatE and CatD activity in subcellularfractions of the cell lines (A) HaCaT, (B) WT100 and (C) DCs. Equalamounts of total protein (20 lg) were used for the determination of CatE...
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Báo cáo khoa học: The lactate dehydrogenases encoded by the ldh and ldhB genes in Lactococcus lactis exhibit distinct regulation and catalytic properties ) comparative modeling to probe the molecular basis pdf

Báo cáo khoa học: The lactate dehydrogenases encoded by the ldh and ldhB genes in Lactococcus lactis exhibit distinct regulation and catalytic properties ) comparative modeling to probe the molecular basis pdf

... of the conformations found in theLDH-Bs.Simulation of the pH titration behavior of ionizing groups of LDH and LDHBThe tetramer structures of lactate dehydrogenases con-taining NADH and Fru(1,6)P2were ... buffer.The kinetic characterization of both LDH and LDHBwas carried out in 100 mm Mes ⁄ KOH (detailed informationabout concentrations and reaction conditions is presented in figure legends and tables). ... additional factor actingas an inhibitor of LDHB, and the best candidate isintracellular lactate. At an external pH of 5.5 (orlower), the13C-resonances of intracellular and extra-cellular...
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Báo cáo khoa học:

Báo cáo khoa học: "An Architecture for Dialogue Management, Context Tracking, and Pragmatic Adaptation in Spoken Dialogue Systems" pot

... increasing decision power for processing flow, in cases of dialogue segment type with which it is familiar. The intended contribution of this work is thus in the generic definition of standard ... func- tions such as dynamic troubleshooting (repair), context updating, anaphora resolution, and translation of natural language interpretations into functional interface languages of back-end ... Pos.~'ihlc Inlml Pos.~ihh" ().tim Speech Reco[nition:: 'NL Interp~tation : Context Tracking on Input Pragmatic Adaptation on Input Convert waveform to Strin~ 6f words ::: Converi...
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Báo cáo khoa học: A single intersubunit salt bridge affects oligomerization and catalytic activity in a bacterial quinone reductase pptx

Báo cáo khoa học: A single intersubunit salt bridge affects oligomerization and catalytic activity in a bacterial quinone reductase pptx

... of initial velocity measurements in the presence of NADPH as the electron donor and 2-hydroxy-p-naphthoquinone as electron acceptor. Thefamily of parallel lines obtained from data analysisindicates ... representation of the four salt-bridges in theYhdA tetramer. One dimer is formed by the green and magentachains; the second by the pink and blue chains.Effect of oligomerization in a quinone reductase ... view of a portion of the dimer–dimer interface.One subunit is shown in light blue; the other in magenta. The FMNcofactor is shown in yellow; hydrogen bonding interactions are indi-cated using...
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Báo cáo khoa học: Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells docx

Báo cáo khoa học: Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells docx

... antioxidant levels, in response t o theinhibition of GA expression, are presented in Table 1. Theinhibition of GA expression decreases the level of GSH,resulting in a 40% re duction of the GSH/GSSG ... growth of EATC and 0.28AS-2 cells during treatment with MTX and H2O2was investigated by using the MTT assay. First, we analysedthe growth curve of EATC and 0 .28AS-2 cells at baseline, and ... simil ar intracellularglutamate concentrations, 0 .28AS-2 cells have significantlyhigher glutamine levels, reflecting the strong inhibition of GA expression (Table 2). The diminished mitochondrialglutamine...
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