báo cáo khoa học: "Phenylhexyl isothiocyanate has dual funct

báo cáo khoa học: "Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways" doc

... Access Research Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways Quanyi ... suppresses growth and causes cell cycle arrest of RPMI8226 myeloma cellsFigure 1 PHI suppresses growth and causes cell cycle arrest of RPMI8226...

Ngày tải lên : 10/08/2014, 22:20

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Tài liệu Báo cáo khoa học: Myristoylation of the dual-speciﬁcity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf

... caspase-9 and poly (ADP-ribose) polymerase (PARP) (Fig. 5C). We detected both cleaved caspase-9 and PARP in JSP1-wt expressing, ﬂoating cells. In contrast, cells expressing the -G2A mutant, and ... carboxamidomethylated and maleylated lyso- zyme as substrate, and phosphatase activity was measured. The results (shown as activity relative to wild-type phosphatase) are the mean of...

Ngày tải lên : 16/02/2014, 14:20

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Báo cáo khoa học: Caenorhabditis elegans has two genes encoding functional D-aspartate oxidases pot

... against the enantiomers l-Asp, l-Glu, and N-methyl-l-Asp and all neutral and basic d-amino acids examined. Thus, the proteins encoded by the cloned C47Ap and F18Ep cDNAs can catalyze the deamination ... Extraction Reagent (Novagen), 50 lm FAD, and protease inhibitors (Roche Applied Science, Mannheim, Germany) (5 mL lysis buffer per g wet cell paste was used). The cell suspen...

Ngày tải lên : 30/03/2014, 10:20

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Báo cáo khoa hoc:" Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils" ppsx

... the other hand, a former study has already revealed an effect of handling on the dopaminergic system without any medication [13]. Interestingly, this handling effect was only significant in saline ... etiology and outcome of psychiatric diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD). A former study from our laboratory has shown that both methylphenidate (MP) and ha...

Ngày tải lên : 11/08/2014, 07:20

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báo cáo khoa học: " What work has to be done to implement collaborative care for depression? Process evaluation of a trial utilizing the Normalization Process Model" potx

... Framework pub- lished in 2007 [10] emph asized the iterative nature of the tasks of defining and understanding the problem and its context, developing and optimizing and then evaluating the intervention, ... challenging, and undoubtedly easier if the first contact was face-to-face: ’They wanted counselling, even though I did emphasize that I wasn’t counselling, it took time, to buil...

Ngày tải lên : 11/08/2014, 16:20

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Báo cáo khoa học: "Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions" ppt

... interaction between Nedd4 and UL56 will help to clarify both cellular process and viral pathogenesis. Methods Cells and viruses Vero cells (African green monkey kidney cells) were obtained from ... PFU/ cell) , and infected cells and growth medium were har- vested together when almost all cells showed cytopathic effects. After a cycle of freezing and thawing, supernatants were...

Ngày tải lên : 12/08/2014, 04:20

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Báo cáo khoa học: "Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections" ppsx

... an important public health problem and indiscriminate use of antibiotics has been implicated as a predisposing factor, it would be useful to have a rapid and ... admitted with suspected lower respiratory tract infection as the main diagnosis. Intervention: Patients were randomly assigned to either standard care (n=199) or PCT-guided treatment (n=124). In ... antibiotics was:...

Ngày tải lên : 12/08/2014, 22:21

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Tài liệu Báo cáo khoa học: A DExD⁄ H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana docx

... Kronzucker HJ & Shi WM (2010) Root growth inhibition by NH 4 + in Arabidopsis is mediated by the root tip and is linked to NH 4 + efﬂux and GMPase activity. Plant Cell Environ 33, 1529–1542. 52 Sun ... surface-sterilized and sown on Murashige and Skoog plates. Seeds were stratiﬁed at 4 °C for 2 days, and then transferred to 22 °C for 2 weeks. Col-0 was used as the wild...

Ngày tải lên : 14/02/2014, 18:20

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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

... its fluorescence was first demonstrated to increase upon binding to amyloid fibrils [20]. It has been used to detect cross b-sheet fibril formation by a-synuclein [19,21,22] as well as b amyloid [23] and huntingtin ... containing MPTP (A and C) and MPP + (B and D) were analysed by SDS ⁄ PAGE (A and B) on 5–15% crosslinked polyacrylamide gel and western blotting (C and D)....

Ngày tải lên : 14/02/2014, 19:20

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Tài liệu Báo cáo khoa học: Exposure of IgG to an acidic environment results in molecular modiﬁcations and in enhanced protective activity in sepsis doc

... an inherent property of each individual immunoglobulin molecule. However, it has been previously shown by us, as well as by others, that the in vitro exposure of monoclonal and of polyclonal IgG to various ... preparations are used in patients with primary and secondary immunodeﬁciencies, as well as in an increasing number of autoimmune and inﬂammatory diseases. To the bes...

Ngày tải lên : 16/02/2014, 15:20

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