... S, Nawata M, Kawaguchi A, Okabe T, Takaoka K, Tsuch-iya T, Nakaoka R, Masuda H, Miyazaki K: Serum keratan sulfateis a promising marker of early articular cartilage breakdown.Rheumatology (Oxford) ... every week by HPLC. The effect of weeklyknee injection of hyaluronan was also investigated.Results Cartilage surfaces stained with India ink becameirregular, metachromasia by safranin-O staining ... hyaluronan in full thickness defects of rat articular carti-lage [6]. In normal articular cartilage, hyaluronan was stainedmainly around the chondrocytes. During repair, strong hyaluro-nan...