Báo cáo y học: "Dasatinib preferentially induces apoptosis by inhibiting Lyn kinase in nilotinib-resistant chronic myeloid leukemia cell line" pot

... pathways [8]. In this study, there was no muta- tion in Abl kinase, but Src family kinases, including Lyn, was activated in the nilotinib-resistant cell line. Lyn kinase has been previously shown ... preferentially induces apoptosis by inhibiting Lyn kinase in nilotinib-resistant chronic myeloid leukemia cell line. Journal of Hemato logy & Oncolo...

Ngày tải lên: 10/08/2014, 21:23

... Cheng JZ, Singhal SS, Sharma A, Saini M, Yang Y, Awasthi S, Zim- niak P, Awasthi YC: Transfection of mGSTA4 in HL-60 cells pro- tects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated ... the apoptosis process elicited by HNE could vary in different cell types due to changes in the availa- bility or sensitivity of specific regulatory pathways that are ac...

Ngày tải lên: 09/08/2014, 13:21

... significant changes in IL- 17 production To clarify the pathways underlying IL-23-induced osteoclas- togenesis, we investigated proinflammatory cytokine production by human T cells stimulated by IL-23. ... expression of proinflammatory cytokines including TNF-α, IL-1β, and IL-6 is markedly reduced in IL-23-deficient (IL-23 p19 -/- ) mice [16]. These cytokines promote bone resorption...

Ngày tải lên: 09/08/2014, 10:21

... Yacoub MH, Barnes PJ, Mitchell JA: Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflam- matory role of this cell type. Br J Pharmacol 1997, 120:910-916. 17. ... extracellular oxidative stress [17]. Heme oxygenase-1 is expressed in most cell types and is highly inducible by oxidative stress. In order to investigate whether CSE ex...

Ngày tải lên: 12/08/2014, 18:21

... has surely been modulated by the absence of any positive effect. Morningness-eveningness preference Finally, we have evaluated Mr. A and Mrs. B morningness or eveningness preference administering ... Colombo 3 Address: 1 Institute of Psychiatry, University of Bologna, Italy, 2 Department of Psychology, Catholic University, Milan, Italy and 3 Department of Psychiatry, San Raffaele Scient...

Ngày tải lên: 08/08/2014, 21:20

... isolated by Ficoll–Hypaque density-gradient centrifugation. Cells were resuspended in buffer contain- ing 0.1% bovine serum albumin and 0.1% NaN 3 at 10 6 cells/ml. Nonspecific antibody binding at ... predominantly T helper type 1 (Th1)-type cytokines in localized WG [3], a shift towards stronger Th2-type cytokine expression is found in granulo- matous lesions of the respiratory tract...

Ngày tải lên: 09/08/2014, 01:21

... purposes) signalling pathway may prove useful for maintaining the chondrocyte phenotype [8]. Conclusion The joint instability models presented herein in contrast to more aggressive models involving for instance ... retinoid signal- ling pathway were found to be significantly elevated in the joints of the aforementioned rat OA joint instability model, including genes encoding proteins invo...

Ngày tải lên: 09/08/2014, 01:22

... indicate that MIF might participate in the pathogenesis of primary Sjögren's syndrome. MIF may contribute to B -cell hyperactivity indicated by hypergammaglobulinemia. The inverse relationship of IL-10 ... broad-spectrum proinflammatory cytokine with a pivotal role in the regulation of innate and adaptive immune responses [5]. There is increasing evidence for a role of MIF as a pr...

Ngày tải lên: 09/08/2014, 10:20

... discovered, denoted by L*, is increased by 100 bp, while for rap1, the final length is increased by 700 bp. These results indicate that up to a certain length, increasing the number of starting points gives ... methods using the EM algorithm can be improved simply by using more starting points or by looking into alternative starting-point procedures. However, there is Table 4 Percen...

Ngày tải lên: 09/08/2014, 20:20

... during actin modulation: rheology and glassy dynamics. Am J Physiol Cell Physiol 2005, 289:C1388-C1395. 65. Cramer LP, Mitchison TJ: Myosin is involved in postmitotic cell spreading. J Cell ... treating cells Anti-nuclear myosin 1b (NM1β) staining patterns in proliferating cells, quiescent cells, and after restimulation Figure 10 Anti-nuclear myosin 1b (NM1β) staining patterns in...

Ngày tải lên: 09/08/2014, 20:21