Báo cáo y học: "Targeting insulin-like growth factor axis in hepatocellular carcinoma" ppsx

... insulin-like growth factor 2; IGF-1R: insulin-like growth factor 1 receptor; IGF-2R: insulin-like growth factor 2 receptor; IRS: insulin receptor substrate; IGFBPs: insulin like growth factor binding ... insights into the value of IGF inhibi- tion in the treatment of HCC. Abbreviations HCC: hepatocellular carcinoma; IGF: insulin-like growth factor; IGF-1: insuli...

Ngày tải lên: 10/08/2014, 21:23

... chondrocytes was based on the blue staining from heama- toxylin instead of brown staining. The average number of chondrocytes per sections was calculated for every joint. Image analysis: proteoglycan ... transforming growth factor (TGF)-beta deprivation on intrinsic cartilage repair capacityEffect of transforming growth factor (TGF)-beta deprivation on intrinsic cartilage repair capa...

Ngày tải lên: 09/08/2014, 07:20

... cautionary tale for genetically uncontrolled studies. Background The epidermal growth factor receptor (EGFR) pathway plays key roles in the development and maintenance of many tissue and organ systems ... backgrounds. The removal of the linked Wnt3a vt hypomorphic allele, main- tained in cis with Egfr wa2 in the initial starting population, was verified by PCR-based genotyping. Mic...

Ngày tải lên: 10/08/2014, 09:20

... the proinflammatory cytokines IL-1β and TNF-α induce the expression of Synovio- lin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway indicating that the proinflammatory cytokines ... high expression of the integrin αVβ3, which binds to a variety of extracellular matrix proteins including vitronectin, osteopontin, and bone sialoprotein. Arg-Gly-Asp (RGD)-con...

Ngày tải lên: 12/08/2014, 11:22

... inflammatory mediators Since PDGF and TGF-β are abundant in the rheumatoid synovium, their effect on cytokine-induced inflammatory mediator secretion by FLS was examined. TGF-β induced only ... Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes Arthritis Research & Thera...

Ngày tải lên: 12/08/2014, 12:20

... lines of in vitro evidence have pointed to a possible role for VEGF in lung repair and recovery following injury[19,29,35,36]. In one LPS- induced murine model of lung injury, intrapulmonary levels ... analysis in snap frozen lung tissue from our multiple dose LPS-induced lung injury model at day 5 post initial injury, reflecting early ARDS [23]. These data supported the human post mo...

Ngày tải lên: 12/08/2014, 14:20

... subjects. In this study, pulmonary hypertension became particularly pronounced in bronchitis-type patients during exercise, indicating that the increase in pulmonary blood flow and hypoxemia during ... This finding suggests that the sensitivity to smoking in bronchitis-type patients differs from that in emphysema-type patients, in some way. In this regard, hereditary predisposit...

Ngày tải lên: 12/08/2014, 15:20

... purposes) matory mediators in sputum not only in bronchitis type of COPD smokers but also in asymptomatic smokers, may indicate that VEGF plays an important signalling role linking the inflammatory milieu ... as suggested by acute increase in VEGF levels during smoking [32]. Although the increase in neutrophils by smoking may explain the increase of VEGF, it may also be the result o...

Ngày tải lên: 12/08/2014, 15:21

... clinical response, suggesting that their RA was not much driven by TNF-α activity alone but probably by other cytokines or mechanisms. The heterogeneity in these patterns may be explained by higher ... functional assay for TNF-α activity was designed using the ability of RA synoviocytes to produce IL-6 and OPG in response to TNF-α [5]. To isolate synoviocytes, RA synovial tissues were fin...

Ngày tải lên: 09/08/2014, 06:22

... secretion may be important for downregulating the endotoxin-induced inflammatory cytokine storm that characterizes early stages of bacterial sepsis. In addition, IL-10 may also finely modulate ... signal-regulated kinase; IFN = interferon; IL = interleukin; INH-ODN = inhibitory oligodeoxynucleotide; MZ = marginal zone; NOD = nucleotide-binding oligomerization domain; ODN = oligodeoxynucleot...

Ngày tải lên: 09/08/2014, 07:20