Báo cáo y học: "Gene expression profiles in BCL11B-siRNA treated malignant T cells" ppt

... in arthritic joints may contribute to arthritis sus- ceptibility and to the inflammatory processes that mediate the pathology of this model. Conclusion The present study identified the temporal ... 5'-6-FAM-TCGGCAAACCTAGTGTGCTATGCCTAAGCA-TAMRA TNF-α 5'-CCAGGTTCTCTTCAAGGGACAA 5'-CTCCTGGTATGAAATGGCAAATC 5'-6-FAM-CCCGACTATGTGCTCCTCACCCACA-TAMRA GRO1 5'-TGTGTTGAAGCTTCCC...

Ngày tải lên: 09/08/2014, 06:22

... recent identification of activating Notch1 mutations in the majori ty of patients with T- ALL has bro ught interests on targeting the Notch signaling pathway for this disease [5]. The B-cell chronic lymphocytic leukemia ... activation by interacting with the p300 co-activator at the upstream site 1 (US1) of the interleukin (IL)-2 promo- ter, leading to transcriptional activation of IL-2 ex...

Ngày tải lên: 10/08/2014, 21:23

... adaptive immunity but have intact innate immunity on an identical (BALB/ c) genetic background. Differential gene expression in response to donor lymphocytes that migrated into the joint can therefore ... interactions between the donor lymphocytes and the synovial/joint cells of recipient mice that lack an adaptive immune system. The list of genes we present in this study is rather shor...

Ngày tải lên: 09/08/2014, 06:22

... to test the in vitro sensitivity of syno- vial cells from TNF-blocking therapy-resistant patients to increasing concentrations of TNF-α-, IL-1β-, or IL-17-blocking agents and finally to identify ... not belong to any rel- evant pathway. It should be stressed in that perspective that RA is not a systemic disease. The inflammatory mechanisms targeted by TNF-blocking agents are located in...

Ngày tải lên: 09/08/2014, 14:20

... progenitors was significantly higher in patients affected by systemic sclerosis than in controls and among patients in those with digital ulcers than in patients without them. Circulating endothelial ... therapy since a statisti- cally significant increase in EPCs has also been observed during atorvastatin treatment in patients with SSc [43]. In SSc patients, CECs were not only...

Ngày tải lên: 12/08/2014, 14:22

... TTC TCC ACA AGC GC IL-8 2 TCT CAG CCC TCT TCA AAA ACT TCT C 3 ATG ACT TCC AAG CTG GCC GTG GCT BMP-6 2 CAC CAT GAA GGG CTG CTT AT 3 GGA CAC CCG TGT AGT ATG GG c-myc 2 GCT GCT ATG GGC AAA GTT TC 3 ... GGC TTC CCA AAT GAG TA 2 TTG ATT TGG AAA CCT CCA GC 3 CCA GGC TTC CCA AAT GAG TA GRO-β 2 GGC CAT TTT CTT GGA TTC CT 3 CCG AAG TCA TAG CCA CAC TC IL-6 2 GAA GAG CCC TCA GGC TGG ACT G 3 AGT AAC TCC...

Ngày tải lên: 09/08/2014, 01:22

... suggest that some of the genes identified by the clustering method did not contribute to the discriminatory power beyond that which was provided by the pattern detected by SDA. Other gene expression ... distinct patterns that fall outside of the autoimmune signature. As an example, preliminary studies of patients with allergic diseases or asthma indicate that there is a distinctly different...

Ngày tải lên: 09/08/2014, 01:23

... rather resulted from enzyme release by cells (including infiltrating inflammatory cells) within the joints. Competing interests The authors declare that they have no competing interests. Authors' ... and osteoarthritis. This does not exclude the possibility that these enzymes may contribute significantly to cartilage degradation in both joint diseases if acting in collaboration with...

Ngày tải lên: 09/08/2014, 14:20

... a cytokine with anti-inflammatory properties in arthritis and was the target of experimental gene therapy experiments [33]. Of interest, mice from the two strains studied did not differ with ... and infiltration into tissue rep- resent the first and determining step in a complex sequence of processes that mediate tissue injury [18-20]. In contrast to our previous study addressing the e...

Ngày tải lên: 09/08/2014, 06:23

... upregulated approximately 3-fold, thus potentially hampering the therapeutic effort. On the contrary, miR-24-1, a member of the miR23b cluster [16] that interferes with Tran sforming Growth Factor ... hypotheses and the design of further experiments validating the initial findings presented here and investigating the functional relevance of microRNA level alterations in the context of radia...

Ngày tải lên: 09/08/2014, 09:20