Báo cáo y học: "Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663" docx

... differentiation in HL-60 cells; however, the function of miR-663 and the mechanism by which it affects HL-60 differentiation requires further study. Conclusion Our study is the first investigation of the effect ... expression of micro- RNAs during HL-60 differentiation, and the expression profiles of human miRNAs during cell differentiation remain largely unkn...

Ngày tải lên: 10/08/2014, 21:23

... of bleeding or cell desquamation) and dietary uptake (by duodenal cells) is only 1 to 2 mg per day, compared to approximately 3 to 4 g of iron contained in the organism. In fact, most of the ... micro lm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law o...

Ngày tải lên: 14/08/2014, 07:21

... ml. Finally, the assumption that the population of latently infected, resting CD4 + T-cells is the only reservoir for HIV- 1 in vivo is largely untested. While the persistence of these cells likely ... develop over the dura- tion of VPA treatment presented in their Lancet study. And yet a proportion of latently infected cells remained after 3 months of therapy. Do these r...

Ngày tải lên: 13/08/2014, 09:21

... For analysis, matrix solutions consisting of sinapinic acid, 3,5-dimethoxy-4-hydroxycinnaminic acid, or a-cyano-4-hydroxycinnamic acid, were mixed in a 1 : 1 ratiowithsamples,spottedonthetargetandallowedto dry. MASSLYNX (Micromass ... these cells is normally around )70 mV, and the voltage that typically activates the maximum, whole -cell Na + conductance in these cells is between )...

Ngày tải lên: 31/03/2014, 08:20

... [11-14]. The overall sensitivity of 89.1% and specificity of 81.1% provided by the 3DMP device in the detection of hemodynamically relevant CAD confirms the results of the smaller study from ... coronary angiography in the study by Weiss et al. showed a higher sensitivity and specificity for the detection of coronary stenosis by 3DMP than by 12-lead ECG [18]. O...

Ngày tải lên: 08/08/2014, 16:23

... methods can only be drawn indirectly from other studies. In conclusion, the mathematical analysis of the ECG by 3DMP appears to provide sensitivity and specificity for the prediction of relevant ... coronary angiography in another study showed a higher sensitivity and specificity for 3DMP than for 12-lead ECG in the detection of coronary stenosis [ 21]. One lim itation...

Ngày tải lên: 08/08/2014, 17:20

... to the full length of open reading frame (ORF) of the NPM-mA gene (935 bp). Figure 1. PCR amplifying the full sequence of ORF of the NPM-mA gene. The PCR products amplified with a pair of ... titre of mice serum reached 1:1024 checked by indirect en- zyme-linked immunosorbent assay (ELISA), myeloma cells line SP2/0 (10 6 ) were fused with splenocytes (10 7 ) by...

Ngày tải lên: 08/08/2014, 18:21

... future. Gene therapy The current use of gene therapy in the treatment of OA is a result of success in identifying major pathophysiological pathways of the disease process. The principle underlying gene therapy ... activity of MMPs. The action of MMPs can be controlled in a number of ways, but the main avenues explored are inhibition of their synthesis and transform...

Ngày tải lên: 09/08/2014, 07:20

... and compromising the physical integrity of the membrane. Central to the pathogenesis of lupus is continuous activation and proliferation of B-lymphocytes and T-lymphocytes with specificity for self-structures ... affinity toward the different MMPs [22]. The central role played by TIMPs in the regulation of MMP activity has led to the hypothesis that shifts in the balan...

Ngày tải lên: 09/08/2014, 13:22

... that the number of genes to be a measure of organismal complexity. Furthermore, the imprecision of the estimate raised questions about the validity of many predicted genes [36]. Although the ... Genome Biology 2010, 11:206 http://genomebiology.com/2010/11/5/206 Page 7 of 7 less than 300, there are several thousand genes in each set that do not map cleanly onto the o...

Ngày tải lên: 09/08/2014, 20:21