Báo cáo y học: "Progression of metastatic castrate-resistant prostate cancer: impact of therapeutic intervention in the post-docetaxel space" pps
Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... determine whether the MREa– protein complex displays sequence specificity. Binding of the HepG2 nuclear proteins to MREa was inhibited by the addition of a molar excess of unlabelled MREa to the binding ... IR. Results of each values were expressed as the following ratio: intensity of WD cDNA/intensity of competitor and then divided by intensity of amplified actin cDNA....
Ngày tải lên: 17/03/2014, 23:20
Báo cáo y học: "β Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis" ppt
... cytokine profile in inflamed synovial tissue. To provide more insight into the mechanism by which IFN- β therapy exerts its beneficial effects, we examined cytokine expression at the site of inflammation. ... erosion of bone were observed in the ankle joint. In CIA mice treated with the highest dose of IFN-β (2.5 µg per injection per mouse), limited hyperplasia of the...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc
... finding in RA, although not consistently observed in the synovial fluid (Table 1). Despite the inconsistency in reporting of differing DPPIV levels between non-inflammatory and inflammatory synovial ... cells infiltrating into the synovium from the periphery. This concept stresses the kinetic nature of synovial inflammation where a single time point assay may identify a sy...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps
... one of the synovial lining cells and thereby fully block the TGF-β-induced fibrosis. We have previously demonstrated that blocking TGF-β with Ad-Smad7 in OA resulted in reduction of the synovial ... overexpression of TGFβ stimulated repair of IL-1- and OA-damaged cartilage. TGFβ- induced synovial fibrosis was blocked by locally inhibiting TGFβ signaling in the synovial l...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt
... inflammatory response in the lungs of mice which is linked to a reduction in HDAC activity and may be a key mechanism of glucocorticoid insensitivity in COPD [11,17,21]. Both this reduction in HDAC ... of key compo- nents of the transcriptional machinery including the core histone proteins resulting in their in re-association with the DNA, thus presenting a transcr...
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: " Part I, Patient perspective: activating patients to engage their providers in the use of evidencebased medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID)" ppsx
... of their hypertension. In addition, patients provided insight as to why the intervention was effective in increasing participation in the intervention. Many of their answers pointed toward findings ... separate the influences of participating in a study from the decision to participate in an intervention? Finally, the results demonstrate the variety of roles...
Ngày tải lên: 11/08/2014, 05:21
Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf
... may lead to the alteration of both the formation and targeting of these complexes. Consequently, an oxidant-mediated reduction in the protein expression of Mi-2α and mSin3a and increased protein ... manner which may be involved in the chronic glucocorticoid insensitive inflammation in the lungs of COPD patients. However, the impact of cigarette smoke exposure o...
Ngày tải lên: 11/08/2014, 06:22
Báo cáo y học: " Isolated radial head dislocation, a rare and easily missed injury in the presence of major distracting injuries: a case report" ppsx
... was involved in reviewing the literature and proof reading of the manuscript. RSUY has approved the final manuscript. SSB is the senior author and was responsible for final proof reading of the ... later, the patient complained of pain in the right elbow. There was no previous history of elbow injury or arthritis. On examination, there was minimal swelling over the...
Ngày tải lên: 11/08/2014, 10:22
Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
... LS/UV/RI 3-detector analysis. Binding kinetics and affinity studies The binding affinities an d kinetics of BLyS (average values were determined from three distinct lots of pro- tein), APRIL (six lots), ... determined from the kineticrateconstants(k a and k d ). The binding curves were processed by double referencing and were globally fitted to a 1:1 binding model. The stoichiomet...
Ngày tải lên: 12/08/2014, 12:20
Báo cáo y học: "Pro/con clinical debate: Is high-frequency oscillatory ventilation useful in the management of adult patients with respiratory failure" ppt
... oscillatory ventilation (HFOV) has become an increasingly common therapy. This may not have been the case if researchers had not persisted in investigating the therapy after early disappointing clinical ... What is the safety and efficacy of the device? As outlined in the following debate, there are several compelling arguments for and against the use of HFOV at this point...
Ngày tải lên: 12/08/2014, 18:21