Báo cáo y học: "Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer" pot

... HDACs may play in XPC gene silencing and bladder cancer development, we first determined the effect of HDAC inhibitor treat- ment on activation of XPC gene transcription in HTB4 and HTB9 bladder ... determine the roles of these epigenetic regulation mechanisms in XPC gene silencing and bladder cancer development in order to pro vide a better understanding o...

Ngày tải lên: 10/08/2014, 21:23

... gelatin zymography, and collagenase activity assays using both SW1353 chondrosarcoma cells and primary human chondrocytes. The HDAC inhibitors trichostatin A and sodium butyrate potently inhibit ... collagenases, and Figure 1 Histone deacetylase inhibitors block cartilage glycosaminoglycan and collagen loss induced by IL-1α/OSMHistone deacetylase inhibitors block cartilage glycosami...

Ngày tải lên: 09/08/2014, 06:22

... mice constitutively expressing Runx2. Conversely, mice over- expressing HDAC4 in cartilage show greatly reduced chondrocyte hypertrophy, similar to that in the Runx2-null phenotype. Commentary Histone deacetylases ... objective. In cartilage cultured in the presence of the cytokines interleukin-1 and oncostatin M, chondrocytes produce enhanced levels of metalloproteinases of the A...

Ngày tải lên: 09/08/2014, 06:23

... B12 deficiency and hyperhomocysteinaemia No vitamin B12 deficiency, mean (SD) Vitamin B12 deficiency, mean (SD) t Test P value No hyperhomocysteinaemia, mean (SD) Hyperhomocysteinaemia, mean ... optimal resorption of vitamin B12 via atrophy of the abdominal mucous membrane ensuing from infection [20]. Atrophy results in an inadequate linking between the consumed vitamin B12 and int...

Ngày tải lên: 08/08/2014, 23:21

... major phenotypic shift occurs in OA toward a de-differentiated chondrocyte [40]. Interestingly, in the present study we observed increased amounts of types I and III collagens by immunohistology in both ... meniscectomy). Changes in collagen subtypes in pathological cartilage may not only influence the biomechanical integrity of the tissue but may sequester and modulate the acti...

Ngày tải lên: 09/08/2014, 06:23

... correlated inversely with the systolic blood pressure by multiple linear regression analysis including variables that may influence the systolic blood pressure (Table 3). Age and the body mass index ... with systemic-sclerosis-related antibodies and markers for inflammatory activity. Inflammatory activity describes an increased erythrocyte sedimentation rate, increased C-reactive protein...

Ngày tải lên: 09/08/2014, 10:20

... Chiang CL, Hsieh YS: Mulberry anthocyanins, cyanidin-3-rutinoside and cyanidin-3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer Letters ... of dietary caraway (Carum carvi L.) on aberrant crypt foci development, fecal steroids, and intestinal alkaline phosphatase activities in 1,2- dimethylhydrazine-induced colon carcin...

Ngày tải lên: 10/08/2014, 09:21

... vast majority of respiratory-related deaths [2]. ARDS formally defined as a syndrome of inflammation and increased permeability, is associated with a constella- tion of clinical, radiological and physiological ... lung resection [1]. Respiratory complications remain the major cause of morbidity and mortality following lung resection. Acute lung injury (ALI) and acute respiratory disea...

Ngày tải lên: 10/08/2014, 09:22

... resid- inginXinjiangthanintheinlandareasofChina. Furthermore, it was higher in local minority groups than in Han subjects. HHV-8 prevalence remained high in blood donors residing in Xinjiang, but classical KS and AIDS-related ... small study populations have bee n carried out in China. In the inland areas of China, HHV-8 seroprevalence in general population was <8% [19,20]....

Ngày tải lên: 12/08/2014, 04:20

... in PC and phosphatidylglycerol (PG) were observed with a concomitant increase in the proportion of phosphatidylserine (PS), phosphatidylinositol (PI), phos- phatidylethanolamine (PE) and sphingomyelin ... elec- trocardiogram, clinical laboratory tests (hematology, clin- ical chemistry, coagulation), and pulmonary function prior to inclusion into the study. Study design and broncho...

Ngày tải lên: 12/08/2014, 15:21