Báo cáo y học: " Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP" pot
Báo cáo y học: " Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP" pot
... Journal of Hematology & Oncology 2011, 4:16
http://www.jhoonline.org/content/4/1/16
Page 12 of 14
REVIEW Open Access
Novel targeted therapeutics: inhibitors of MDM2,
ALK and PARP
Yuan Yuan
1
, Yu-Min ... stauros-
porine and HSP90 inhibitors, which are not potent and
specific inhibitors of ALK [58]. Subsequently, using
homology modeling to assist the screenin...
Báo cáo y học: "Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis" pdf
... locally and systemically
in AIA rats.
To quantitatively assess the degree of systemic depletion of
activated macrophages by FTI, uptake of EC20 was analyzed
in the spleen and liver of AIA rats by ... anakinra blocks the activity of
interleukin (IL)-1 [8-10]. Celecoxib and Vioxx are inhibitors of
cyclooxygenase-2 [11], and anti-oxidants inactivate reactive
oxygen species....
Báo cáo y học: "Novel self-epitopes derived from aggrecan, fibrillin, and matri" ppt
... Netherlands
3
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The
Netherlands
4
Department of Medicine and Pediatrics ... Carducci 15, 92100 Milan, Italy
6
Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlan...
Báo cáo y học: "Novel therapies for treatment of gout and hyperuricemia" pot
... inter-
mediate form 5-hydroxyisourate, and subsequent hydrolysis
of this produces 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazo-
line, which is decarboxylated to S-(+)-allantoin [63]. The
enzymes carrying out ... the treatment of gout: 5-yr find-
ings of the FOCUS efficacy and safety study. Rheumatology
2009, 48:188-194.
50. Hu M, Tomlinson B. Febuxostat in the management of hyper-
ur...
Báo cáo y học: "Novel anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet" pptx
... suppress inflammatory respo nse [17-19].
In support of the presence of this mechanism in adipo-
cytes, activation of NFB and MAPK pathways in adipo-
cytes by LPS is transient and rapidly returns to ... properly cited.
Therefore, we examined w hether treatment of adipo-
cytes with peptidoglycan and LPS, l igands for TLR2 and
TLR4, could alter the expression of S LPI. Both pe...
Báo cáo y học: " Novel anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet" docx
... an
assay sensitivity of < 7 pg/ml and an inter assay and
intra assay variation of < 10%.
Statistical analyses
All data were checked for normality and then analyzed
using the GLM model analysis. ... adipocytes and whole adi-
pose tissue (Figures 2A, B and 2C).
Regulation of SLPI expression in adipocytes by
inflammatory stimuli and anti-inflammatory effect of SLPI
Adip...
Báo cáo y học: " Post-traumatic glioma: Report of one case and review of the literature"
...
of CT and magnetic resonance imaging (MRI), some
of the pathologic criteria can be replaced or supple-
mented by imaging criteria. CT/MRI, which elegantly
reveal the severity and location of ...
presence of the tumor must be clearly differentiated
from that caused by trauma.
3. Tumor tissue should be in direct continuity
with the traumatic scar, not merely in its vicinity or...
Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... M, Miyano Y, et al. Emergence and takeover of YMDD motif mutant hepatitis B
virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy. Hepatology 1998;27:1711-1716. ... use of a genotyping assay for polymerase mutant detection and
quantitative detection of viremia with a highly sensitive assay is warranted for optimal monitoring of HB...
Báo cáo y học: "A cross-sectional analysis of video games and attention deficit hyperactivity disorder symptoms in adolescents" pps
... past year? YES NO If yes, how many times?
Have you been in a physical fight in the past year? YES NO If yes, how many times?
Have you been arrested in the past year? YES NO If yes, how many times?
Do ... How often do you try to cut down the amount of time you spend playing video
games and fail?
18. How often do you try to hide how long you've been playing video games?
19. How often...
Báo cáo y học: "IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis κ synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways" doc
... factor
production by rheumatoid arthritis synoviocytes and its regu-
lation by Th2 cytokines. J Immunol 1998, 161:409-414.
25. Aggarwal S, Gurney A: IL-17: prototype member of an emerg-
ing cytokine family. ... hours and
assayed for the production of IL-6 and IL-8 by sandwich ELISA. Effects
of NF-κB blockade and CD40 ligation were investigated by adding 3 µM
PDTC and 10 ng/ml...