Báo cáo y học: " Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP" pot

... Journal of Hematology & Oncology 2011, 4:16 http://www.jhoonline.org/content/4/1/16 Page 12 of 14 REVIEW Open Access Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP Yuan Yuan 1 , Yu-Min ... stauros- porine and HSP90 inhibitors, which are not potent and specific inhibitors of ALK [58]. Subsequently, using homology modeling to assist the screenin...

Ngày tải lên: 10/08/2014, 21:23

... locally and systemically in AIA rats. To quantitatively assess the degree of systemic depletion of activated macrophages by FTI, uptake of EC20 was analyzed in the spleen and liver of AIA rats by ... anakinra blocks the activity of interleukin (IL)-1 [8-10]. Celecoxib and Vioxx are inhibitors of cyclooxygenase-2 [11], and anti-oxidants inactivate reactive oxygen species....

Ngày tải lên: 09/08/2014, 08:22

... Netherlands 3 Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands 4 Department of Medicine and Pediatrics ... Carducci 15, 92100 Milan, Italy 6 Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlan...

Ngày tải lên: 09/08/2014, 08:23

... inter- mediate form 5-hydroxyisourate, and subsequent hydrolysis of this produces 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazo- line, which is decarboxylated to S-(+)-allantoin [63]. The enzymes carrying out ... the treatment of gout: 5-yr find- ings of the FOCUS efficacy and safety study. Rheumatology 2009, 48:188-194. 50. Hu M, Tomlinson B. Febuxostat in the management of hyper- ur...

Ngày tải lên: 09/08/2014, 14:21

... suppress inflammatory respo nse [17-19]. In support of the presence of this mechanism in adipo- cytes, activation of NFB and MAPK pathways in adipo- cytes by LPS is transient and rapidly returns to ... properly cited. Therefore, we examined w hether treatment of adipo- cytes with peptidoglycan and LPS, l igands for TLR2 and TLR4, could alter the expression of S LPI. Both pe...

Ngày tải lên: 11/08/2014, 03:20

... an assay sensitivity of < 7 pg/ml and an inter assay and intra assay variation of < 10%. Statistical analyses All data were checked for normality and then analyzed using the GLM model analysis. ... adipocytes and whole adi- pose tissue (Figures 2A, B and 2C). Regulation of SLPI expression in adipocytes by inflammatory stimuli and anti-inflammatory effect of SLPI Adip...

Ngày tải lên: 11/08/2014, 06:22

... of CT and magnetic resonance imaging (MRI), some of the pathologic criteria can be replaced or supple- mented by imaging criteria. CT/MRI, which elegantly reveal the severity and location of ... presence of the tumor must be clearly differentiated from that caused by trauma. 3. Tumor tissue should be in direct continuity with the traumatic scar, not merely in its vicinity or...

Ngày tải lên: 25/10/2012, 11:48

... M, Miyano Y, et al. Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy. Hepatology 1998;27:1711-1716. ... use of a genotyping assay for polymerase mutant detection and quantitative detection of viremia with a highly sensitive assay is warranted for optimal monitoring of HB...

Ngày tải lên: 03/11/2012, 09:41

... past year? YES NO If yes, how many times? Have you been in a physical fight in the past year? YES NO If yes, how many times? Have you been arrested in the past year? YES NO If yes, how many times? Do ... How often do you try to cut down the amount of time you spend playing video games and fail? 18. How often do you try to hide how long you've been playing video games? 19. How often...

Ngày tải lên: 08/08/2014, 21:20

... factor production by rheumatoid arthritis synoviocytes and its regu- lation by Th2 cytokines. J Immunol 1998, 161:409-414. 25. Aggarwal S, Gurney A: IL-17: prototype member of an emerg- ing cytokine family. ... hours and assayed for the production of IL-6 and IL-8 by sandwich ELISA. Effects of NF-κB blockade and CD40 ligation were investigated by adding 3 µM PDTC and 10 ng/ml...

Ngày tải lên: 09/08/2014, 01:23