Báo cáo y học: "Unfolded protein response in cancer: the Physician’s perspective" pot

... protein chaperone functions of the HSP90 complex. The interaction between the heat shock pro- tein family and the key proteins in the UPR pathway may, in part, be mediated by their destabilizing ... advantage for the agents that target the UPR to achieve the specificity in cancer therapy. The therapeu- tic potential of targeting the UPR components in cancer mainl...

Ngày tải lên: 10/08/2014, 21:23

... known rise in serum albumin levels in these patients (data not shown). Identification of the other peaks is currently being investigated and may yield novel information on the pathophysiology of SJIA. ... Furthermore, the proteins observed represent only a fraction of those present in the serum. We observed only a subset of relatively high-abundance proteins, limited by their co...

Ngày tải lên: 09/08/2014, 06:22

... significantly r educed in ppg1 cells, in agreement with the low glycogen levels. Interestingly, a recent large- scale yeast two -hybrid screen for protein protein interac- tions [48] has revealed the ... rcelona, Spain. E-mail: Joaquin.Arino@uab.es Abbreviations: MAP kinase, mitogen activated protein kinase; TOR, target of rapamycin; PP1, type 1 protein phosphatase; PP2A, type 2A...

Ngày tải lên: 17/03/2014, 23:20

... tissues of the synovial joint, the OP- 1 found in SF could be derived from any or all of these tissues; this remains to be clarified. Another interesting finding is that OP-1 was present in the cleaved ... proinflammatory cytokines and proteinases, in such analyses may provide a better under- standing of the processes occurring in the articular joint. Conclusion Taken togeth...

Ngày tải lên: 09/08/2014, 08:22

... antithro mbin III (synonymous with SERPINC1), and inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4; synonymous with inter-alpha-trypsin inhibitor family heavy chain-related protein, IHRP), ... factor-binding protein 4; IHRP: inter-alpha-trypsin inhibitor family heavy chain-related protein; IPI: international Protein Index; ITIH4: inter-alpha-trypsin inhibitor heavy chain H4; iTRAQ: ....

Ngày tải lên: 10/08/2014, 21:23

... analyze the inflammatory response represented by the pro-inflammatory cytokine IL-6, the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1RA) and the chemokine GROα in the operated, ... performed the pleural lavages and the surgery, was involved in the statistical analysis and the drafting of the manuscript; DO was involved in the design of th...

Ngày tải lên: 11/08/2014, 03:20

... followed by a return in sensitivity. A second abnormality is seen at postnatal day 5 (P5) rats in that they cannot maintain the increase in frequency for 5 min of hypercapnia. In mice lacking GAD65 the release ... frequency was not seen. In adult rats injections of a GABA synthesis inhibitor into the pos- terior hypothalamus augmented both the respiratory fre- quency and int...

Ngày tải lên: 12/08/2014, 18:21

Ngày tải lên: 13/08/2014, 01:20

... the increase in monocyte apoptosis, and the lower release of pro-inflammatory cytokines, namely tumor necrosis factor-alpha and interleukin-6, from monocytes after stimula- tion with lipopolysaccharide ... stimulation by endotoxin [4]. Endotoxin tolerance has been considered a paradigm of immunoparalysis [5], which is present not only in sepsis but also in systemic inflammatory res...

Ngày tải lên: 13/08/2014, 20:21

... shift in practice from tradi- tional hourly rate goals in which nurses can increase the hourly rate depending on how many hours they have left in the day to ensure that the patient receives the ... instructed to ask the physician to order gastrointestinal prokinetic agents (metoclopramide first, erythromycin as the second line therapy), if appropriate. The dietitian usuall...

Ngày tải lên: 13/08/2014, 20:22