VASCULAR COMPLICATIONS OF DIABETES - PART 6 doc
VASCULAR COMPLICATIONS OF DIABETES - PART 6 doc
... with diabetes
over the age of 30 is partly due to the difficulty in determining the precise
date of onset of disease. The prevalence of retinopathy at the time of diag-
nosis of type 2 diabetes ... the development of dia-
betic retinopathy. The US Diabetes Control and Complications Trial (DCCT)
evaluated the rates of development of microvascular complications in tw...
VASCULAR COMPLICATIONS OF DIABETES - PART 8 doc
... 5.4 5. 5 -6 .9 ≥ 7 diabetes trend)
Cause of death (n=1204) (n- 160 6) (n= 161 1) (n=81) (n= 160 ) P value
All causes (n=135)
Age adjusted rate/100 1 .65 (18) 2.33 (35) 3.43 (61 ) 4.35 (5) 5.92 ( 16) 40.8
Relative ... as 3-
deoxyglucosone (3-DG) and methylglyoxal (MGO). 3-DG is formed by non-
oxidative rearrangement and hydrolysis of Amadori adducts and from fruc-
tose-3-phosphate, w...
VASCULAR COMPLICATIONS OF DIABETES - PART 9 doc
... (% of control)
150
140
130
120
110
100
0
0
100
110
120
130
140
150
160
170
0
010
-1 1
10
-1 0
10
-9
TPA (M)
10
-8
10
-7
10
-6
n.s
10 20
Glucose (mM) Mannose
30 40 520 mmol
Table 21.1 Diabetes- related ... -
Retina Rat, canine ↑↑ - II, δ
Aorta Rat, canine ↑↑ -
Glomeruli Rat, mouse ↑↑ - , - I, -
Monocytes Human NM ↑ - II
↑ = increased; NM = not...
VASCULAR COMPLICATIONS OF DIABETES - PART 1 ppt
... 4. Vascular Diseases etiology.
WK 835 V3305 2005] I. Donnelly, Richard, 1 96 0- II. Horton, Edward S.
RC700.D5V375 2005
61 6.1'3 dc22
2005008488
ISBN-13: 97 8-1 -4 05 1-2 78 5-1
ISBN-10: 1-4 05 1-2 78 5 -6
A ... (%)
20
10
0
30
Cumulative incidence of ESRD (%)
20
10
0
30
Cumulative incidence of IEA (%)
20
10
0
0 8 16 24 32 40 48 56 64
0 8 16 24 32 40 48 56 64...
VASCULAR COMPLICATIONS OF DIABETES - PART 2 pot
... scale)
10000
1000
100
10
1
0
10–14
15–19
20–24
25–29
35–39
30–34
40–44
45–49
55–59
65 69
50–54
60 64
Age (years)
SECTION I • MICRO- AND MACROVASCULAR COMPLICATIONS OF DIABETES
22
CONCLUSION
Risk factors for the micro- and macrovascular complications of diabetes are
similar ... cohort
study found a history of MI in 16. 5% of males and 9.7% of females at the time
of dia...
VASCULAR COMPLICATIONS OF DIABETES - PART 3 potx
... with diabetes. Much of our infor-
mation on interventions that prevent or retard the vascular complications of
diabetes are derived from either sub-group analyses of larger trials, or extrap-
olation ... Cohort Study, I: all-cause mortality in patients with insulin-treated diabetes
mellitus; Diabet. Med. 1999; 16: 459– 465 .
SECTION I • MICRO- AND MACROVASCULAR COMPLICATIONS...
VASCULAR COMPLICATIONS OF DIABETES - PART 4 pot
... 258– 268 .
The Diabetes Control and Complications Trial Research Group. The effect of intensive
treatment of diabetes on the development and progression of long-term complications
in insulin dependent diabetes ...
Copyright © 2005 by Blackwell Publishing Ltd
SECTION I • MICRO- AND MACROVASCULAR COMPLICATIONS OF DIABETES
66
Revascularization
Urgent revascularization is...
VASCULAR COMPLICATIONS OF DIABETES - PART 5 ppsx
... In the
Diabetes Control and Complications Trial (DCCT) ‘clinically detectable’ neu-
ropathy was found in 39% of the participants who had type 1 diabetes. In the
Epidemiology of Diabetes Complications ... VEGF expres-
sion in controls. Intramuscular gene transfer of plasmid DNA encoding VEGF-
1 or VEGF-2 in the STZ-diabetic rat and alloxan diabetic rabbit results in restora-
tio...
VASCULAR COMPLICATIONS OF DIABETES - PART 7 pptx
... oedema P No. oedema P
Non-proliferative
Mild 172 1.7 – 152 2 .6 – 1 26 6.3 –
Moderate
to severe 128 20.3 <0.001 60 36. 7 <0.001 87 63 .2 <0.001
Proliferative 85 69 .7 – 26 73.1 – 35 74.3
*Percentage ... five years of diagnosis, increasing to 67 % in those
with diabetes of >35 years duration. In type 2 diabetes, the corresponding
prevalence rates are 2% rising to 16%...
VASCULAR COMPLICATIONS OF DIABETES - PART 10 potx
... vessels elsewhere 145, 1 46, 163 , 164 ,
165
pathogenesis 166
retinal detachment 145 6
treatment 166 –7, 167
vascular permeability factor 166
vitrectomy 168 –9
vitreous detachment 166
protein kinase C ... retinopathy 144 6, 163 –70
definitions 163 –4, 164 , 165
diagnosis/natural history 164 6, 165
disc new vessels 145, 164
epidemiology 163
iris neovascularization 164 , 165
laser...
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