Physics, Pharmacology and Physiology for Anaesthetists - 5 potx

... useful effects and its toxic effects. It is often defined as LD 50 =ED 50 Log 10 dose 0 Percentage of population responding 50 100 ED 50 ED 95 LD 50 Both curves are sigmoid as before, The curve ... and is, therefore, constant. Non-competitive antagonist curve Log 10 dose 0 Percentage of population responding 50 25 100 With non-competitive antagonist Full agonist Because...

Ngày tải lên: 10/08/2014, 18:21

... 12 1 .5 3 6 2 3 .5 5 Toxic plasma level (mg.ml À1 ) > ;5 > ;5 >1 .5 >4 > ;5 pKa 8.9 8 .5 7.9 7.7 8.1 8.1 7.6 Protein bound (%) 6 75 70 55 95 94 77 Relative lipid solubility 1 200 150 50 1000 ... 30– 35 154 0.4 0.4 0.4 1 25 279 7.4 Haemaccel Polygelines 30– 35 1 45 5.1 6. 25 0 1 45 301 7.3 Hydroxyethyl starch (HES) Esterified amylopectin 450 154 0 0 0 154 Dextran...

Ngày tải lên: 10/08/2014, 18:21

... print format ISBN-13 97 8-0 -5 2 1-7 004 4-3 ISBN-13 97 8-0 -5 1 1-3 8 85 7-6 © M. Cross and E. Plunkett 2008 Every effort has been made in preparing this publication to provide accurate and up-to- date information ... London, UK Foreword by Tom E. Peck MBBS BSc FRCA Consultant Anaesthetist, Royal Hampshire County Hospital, Winchester, UK Physics, Pharmacology and Ph...

Ngày tải lên: 10/08/2014, 18:21

... transient respiratory effort and draws fresh gas over the sensor. 58 Section 2 Á Physical principles Haemoglobin absorption spectra Wavelength (nm) 50 0 600 700 660 8 05 940 Oxy-Hb Deoxy-Hb Red Isobestic ... phases of oil and gas in a closed system at equilibrium and at standard temperature and pressure. Bunsen solubility coefficient The volume of gas, corrected to standard tempera...

Ngày tải lên: 10/08/2014, 18:21

... but which are included for completeness. Group 1 Dose-related reactions Group 2 Non-dose-related reactions Group 3 Dose- and time-related reactions Group 4 Time-related reactions Group 5 Withdrawal reactions Group ... directions. Dextro- and laevorotatory Compounds can be labelled according to the direction in which a molecule of the substance will rotate polarized light. Abbreviated...

Ngày tải lên: 10/08/2014, 18:21

... venous pressure waveform The a wave This is caused by atrial contraction and is, therefore, seen before the carotid pulsation. It is absent in atrial fibrillation and abnor- mally large i f the ... ventricle (RV) is a low-pressure/tension ventricle compared with the left, CBF continues throughout systole and diastole without falling to zero. Right CBF ranges between 5 and 15 ml.min...

Ngày tải lên: 10/08/2014, 18:21

... generic form of the equation states that, for an acid pH ¼ pK a þ log ½ionized form ½un-ionized form and for a base pH ¼ pK a þ log ½un-ionized form ½ionized form 174 Section 8 Á Renal physiology Sodium ... vascular resistance, at 50 – 150 dyne.s.cm 5 . 168 Section 7 Á Cardiovascular physiology Glucose handling 600 50 0 400 300 200 100 0 01020 Plasma glucose (mmol.l –1 ) 30...

Ngày tải lên: 10/08/2014, 18:21

Ngày tải lên: 13/08/2014, 11:22

... ‘The sources and aims of innovation in services: variety between and within sectors’, Centre for Research on Innovation and Competition discus- sion paper no. 55 , November. Thomke, S. and E. von ... rela- tive advantages of the so-called ‘pure-play’ retailers (Internet retailing only, for example Amazon) versus the ‘clicks -and- mortar’ (established retailers moving into Interne...

Ngày tải lên: 07/08/2014, 02:20