Endocrinology Basic and Clinical Principles - part 7 ppsx
Endocrinology Basic and Clinical Principles - part 7 ppsx
... (1[OH ]-2 4,25,26,2 7- tetranor-23-COOH-D) or 1,25(OH) 2 D-26,23-lactone. 24,25(OH) 2 D can also be metabolized by two pathways leading to either 25,26, 2 7- trinor-24-COOH-D or 24, 25,26, 2 7- tetranor-23-COOH-D. 2.1.4. ... of 7- dehydrocholesterol (provitamin D) in the epidermis (Fig. 2). Near-ultra- violet (UV) light with a wavelength of 290–315 nm opens the B-ring by cleaving the bo...
Ngày tải lên: 10/08/2014, 18:21
Endocrinology Basic and Clinical Principles - part 1 ppsx
... of TGF-β class. ENDOCRINOLOGY v Endocrinology: Basic and Clinical Principles, Sec- ond Edition aims to provide a comprehensive knowl- edge base for the applied and clinical science of endocrinology. ... con- cise and comparative format. Endocrinology: Basic and Clinical Principles, Sec- ond Edition will be useful to physicians and scientists as well as to students w...
Ngày tải lên: 10/08/2014, 18:21
Endocrinology Basic and Clinical Principles - part 10 ppsx
... hypothalamus, 377 Kallman syndrome defects, 2 37 Hypothyroidism, clinical features, 278 etiology, 277 – 279 pathophysiology, 2 47, 248 treatment, 278 Hypoxia-inducible factor-α (HIF-α), receptor signaling, 30 I IGFs, ... pathways, arcuate nucleus, 376 , 377 , 379 dorsomedial hypothalamus, 377 history of study, 376 lateral hypothalamic area, 378 paraventricular hypothalamic nucleus,...
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Endocrinology Basic and Clinical Principles - part 2 pdf
... PRL) The GH and PRL receptors belong to a large super- family of receptors that include the cytokine receptors for interleukin-2 (IL-2), IL-3, IL-4, IL-5, IL-6, IL -7 , IL-9, IL-11, IL-12, erythropoietin, ... colony-stimulating factor, interferon-β (IFN-β), IFN-γ, and CNTF. Many of these receptors are heterodimers consisting of an α-ligand-binding subunit and a β-signaling subunit. How...
Ngày tải lên: 10/08/2014, 18:21
Endocrinology Basic and Clinical Principles - part 3 pot
... Prostaglandins and Leukotrienes 93 93 From: Endocrinology: Basic and Clinical Principles, Second Edition (S. Melmed and P. M. Conn, eds.) © Humana Press Inc., Totowa, NJ 7 Prostaglandins and Leukotrienes Locally ... suppress- ing cell-mediated immunity (T-cell). EAE, collagen- induced arthritis and AA are all considered to be primarily T-cell-mediated disease models. Testost...
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Endocrinology Basic and Clinical Principles - part 4 pptx
... corpus luteum, which secretes progesterone, 20α-hydroxy- 4-pregnen-3-one, pregnenolone, 17 -hydroxypro- gesterone, 4-androstenedione, estrone, and estradiol. In bovine and ovine corpora lutea, although large ... steroidogenesis are exemplified, on the one hand, by the bovine corpus luteum, which secretes progesterone, 20β-hydroxy-4-pregnen-3-one, and preg- nenolone, and on the other h...
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Endocrinology Basic and Clinical Principles - part 5 pptx
... the gene, including the 39-amino-acid adrenocorticotropin (ACTH), α-mel- anocyte-stimulating hormone (α-MSH), β-MSH,β-lipo- tropin (β-LPH), β-endorphin, and corticotropin-like intermediate lobe ... of acid hypo- thalamic extracts released LH from rat anterior pituitar- ies. The structure of GnRH was elucidated in 1 971 . The decapeptide pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg- Pro-Gly-amide was...
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Endocrinology Basic and Clinical Principles - part 6 pps
... (BMI >38 kg/m 2 ). PPAR-γ exists as two isoforms, PPAR- -1 and -2 , derived by alternate pro- moter usage, and much interest has focused on a poly- morphism in the PPAR- -2 gene that is exclusively expressed ... hypercalce- mia results. Some tumors such as lymphomas cause hypercalcemia through the presence of a 2 5-( OH )- vitamin D-1αa-hydroxylase enzyme that converts 2 5...
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Endocrinology Basic and Clinical Principles - part 8 pdf
... variety of cytokines and growth fac- tors (including interleukin-1α [IL-α] and IL-β, tumor necrosis factor-α [TNF-α], and transforming growth factor [TGF-β], as well as ANP and BNP) can stimulate CNP ... natri- uretic peptide receptor-A (NPR-A) and NPR-B. A third receptor subtype, called the clearance receptor or NPR- C, shares approx 30% homology with NPR-A and NPR- B in the extr...
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Endocrinology Basic and Clinical Principles - part 9 pot
... Sequence Ang I Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu Ang II Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Ang III Arg-Val-Tyr-Ile-His-Pro-Phe Ang IV Val-Tyr-Ile-His-Pro-Phe Ang 1 -7 Asp-Arg-Val-Tyr-Ile-His-Pro Chapter ... GLP-1 (7 36) = glucagon- like peptid-2 ( 7- 3 6); PP = pancreatic polypeptide; TRH = thyro- tropin-releasing hormone. Chapter 24 / Reproduction and Fertility 3 67 3 67 From: Endo...
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