Endocrinology Basic and Clinical Principles - part 6 pps
Endocrinology Basic and Clinical Principles - part 6 pps
... (BMI >38 kg/m 2 ). PPAR-γ exists as two isoforms, PPAR- -1 and -2 , derived by alternate pro- moter usage, and much interest has focused on a poly- morphism in the PPAR- -2 gene that is exclusively expressed ... also cause hyper- calcemia through similar mechanisms. A number of cytokines including the interleukins IL-1β and IL -6 , tumor necrosis factor-β, and RANKL, as wel...
Ngày tải lên: 10/08/2014, 18:21
Endocrinology Basic and Clinical Principles - part 1 ppsx
... of TGF-β class. ENDOCRINOLOGY v Endocrinology: Basic and Clinical Principles, Sec- ond Edition aims to provide a comprehensive knowl- edge base for the applied and clinical science of endocrinology. ... con- cise and comparative format. Endocrinology: Basic and Clinical Principles, Sec- ond Edition will be useful to physicians and scientists as well as to students w...
Ngày tải lên: 10/08/2014, 18:21
Endocrinology Basic and Clinical Principles - part 7 ppsx
... (1[OH ]-2 4,25, 26, 2 7- tetranor-23-COOH-D) or 1,25(OH) 2 D- 26, 23-lactone. 24,25(OH) 2 D can also be metabolized by two pathways leading to either 25, 26, 27-trinor-24-COOH-D or 24, 25, 26, 27-tetranor-23-COOH-D. 2.1.4. ... of L-thyroxine (T 4 ) and its major metabolites, T 3 and reverse T 3 (rT 3 ). The enzymes include type I 5´-deiodinase (D1), type II 5´-deiodinase (D2), and...
Ngày tải lên: 10/08/2014, 18:21
Endocrinology Basic and Clinical Principles - part 10 ppsx
... 159, 160 leptin, discovery and significance in domestic animals, 165 , 166 food intake regulation, 166 luteinizing hormone regulation, 167 puberty, 166 , 167 secretion characteristics, 166 male ... drop out. In a 2 6- wk randomized, double-blind, placebo-con- trolled parallel-group trial in healthy elderly men and women, the effects of GH and/ or sex steroids (test- osterone in me...
Ngày tải lên: 10/08/2014, 18:21
Endocrinology Basic and Clinical Principles - part 2 pdf
... PRL) The GH and PRL receptors belong to a large super- family of receptors that include the cytokine receptors for interleukin-2 (IL-2), IL-3, IL-4, IL-5, IL -6 , IL-7, IL-9, IL-11, IL-12, erythropoietin, ... colony-stimulating factor, interferon-β (IFN-β), IFN-γ, and CNTF. Many of these receptors are heterodimers consisting of an α-ligand-binding subunit and a β-signaling subunit. Howe...
Ngày tải lên: 10/08/2014, 18:21
Endocrinology Basic and Clinical Principles - part 3 pot
... IGF-1, and IGF-2 [mannose -6 - phosphate, or M -6 - P] receptors), and six well-characterized binding proteins (IGFBPs 1 6) . The IGFs have structures that resemble insulin, hence their names, and were ... Prostaglandins and Leukotrienes 93 93 From: Endocrinology: Basic and Clinical Principles, Second Edition (S. Melmed and P. M. Conn, eds.) © Humana Press Inc., Totowa, NJ 7...
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Endocrinology Basic and Clinical Principles - part 4 pptx
... corpus luteum, which secretes progesterone, 20α-hydroxy- 4-pregnen-3-one, pregnenolone, 17β-hydroxypro- gesterone, 4-androstenedione, estrone, and estradiol. In bovine and ovine corpora lutea, although large ... steroidogenesis are exemplified, on the one hand, by the bovine corpus luteum, which secretes progesterone, 20β-hydroxy-4-pregnen-3-one, and preg- nenolone, and on the other h...
Ngày tải lên: 10/08/2014, 18:21
Endocrinology Basic and Clinical Principles - part 5 pptx
... the gene, including the 39-amino-acid adrenocorticotropin (ACTH), α-mel- anocyte-stimulating hormone (α-MSH), β-MSH,β-lipo- tropin (β-LPH), β-endorphin, and corticotropin-like intermediate lobe ... longer action and different activities than somatostatin, and do not require iv administration. The best-studied among these analogs is octreotide (D-Phe-Cys-Phe-D-Trp- Lys-Thr-Cys-Thr[ol]),...
Ngày tải lên: 10/08/2014, 18:21
Endocrinology Basic and Clinical Principles - part 8 pdf
... variety of cytokines and growth fac- tors (including interleukin-1α [IL-α] and IL-β, tumor necrosis factor-α [TNF-α], and transforming growth factor [TGF-β], as well as ANP and BNP) can stimulate CNP ... natri- uretic peptide receptor-A (NPR-A) and NPR-B. A third receptor subtype, called the clearance receptor or NPR- C, shares approx 30% homology with NPR-A and NPR- B in the extr...
Ngày tải lên: 10/08/2014, 18:21
Endocrinology Basic and Clinical Principles - part 9 pot
... Sequence Ang I Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu Ang II Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Ang III Arg-Val-Tyr-Ile-His-Pro-Phe Ang IV Val-Tyr-Ile-His-Pro-Phe Ang 1-7 Asp-Arg-Val-Tyr-Ile-His-Pro Chapter ... (7– 36) = glucagon- like peptid-2 ( 7-3 6) ; PP = pancreatic polypeptide; TRH = thyro- tropin-releasing hormone. Chapter 24 / Reproduction and Fertility 367 367 From: Endocrin...
Ngày tải lên: 10/08/2014, 18:21