Endocrinology Basic and Clinical Principles - part 5 pptx
Endocrinology Basic and Clinical Principles - part 5 pptx
... the gene, including the
39-amino-acid adrenocorticotropin (ACTH), α-mel-
anocyte-stimulating hormone (α-MSH), β-MSH,β-lipo-
tropin (β-LPH), β-endorphin, and corticotropin-like
intermediate lobe ... somatostatin, and do not
require iv administration. The best-studied among
these analogs is octreotide (D-Phe-Cys-Phe-D-Trp-
Lys-Thr-Cys-Thr[ol]), which is currently used exten-
sively in neuro...
Endocrinology Basic and Clinical Principles - part 4 pptx
... Consequently,
the primary androgens produced by the immature rat
testes are androstenedione, 5 α-androstanediol, and 5
α-dihydrotestosterone. After d 40 of age, 5 α-reduc-
tase activity decreases, and because ... corpus
luteum, which secretes progesterone, 20α-hydroxy-
4-pregnen-3-one, pregnenolone, 17β-hydroxypro-
gesterone, 4-androstenedione, estrone, and estradiol. In
bovine a...
Endocrinology Basic and Clinical Principles - part 1 ppsx
... 1 -5 882 9-4 2 7-7 (alk. paper) eISBN 1 -5 9 25 9-8 2 9-3
1. Endocrinology. 2. Hormones. 3. Endocrine glands—Diseases. I. Melmed, Shlomo. II. Conn, P. Michael.
QP187.E 555 20 05
612.4—dc22 2004018638
32 Part ... of TGF-β class.
ENDOCRINOLOGY
v
Endocrinology: Basic and Clinical Principles, Sec-
ond Edition aims to provide a comprehensive knowl-
edge base for the app...
Endocrinology Basic and Clinical Principles - part 2 pdf
... PRL)
The GH and PRL receptors belong to a large super-
family of receptors that include the cytokine receptors
for interleukin-2 (IL-2), IL-3, IL-4, IL -5 , IL-6, IL-7,
IL-9, IL-11, IL-12, erythropoietin, ... sequester and prevent steroids
from being metabolized and/ or cleared from the blood-
stream. SHBG binds DHT with high affinity (k
d
~ 0 .5
nM) and testosterone and E
2
with ap...
Endocrinology Basic and Clinical Principles - part 3 pot
... Prostaglandins and Leukotrienes 93
93
From: Endocrinology: Basic and Clinical Principles, Second Edition
(S. Melmed and P. M. Conn, eds.) © Humana Press Inc., Totowa, NJ
7
Prostaglandins and Leukotrienes
Locally ... suppress-
ing cell-mediated immunity (T-cell). EAE, collagen-
induced arthritis and AA are all considered to be
primarily T-cell-mediated disease models. Testoster...
Endocrinology Basic and Clinical Principles - part 6 pps
... hypercalce-
mia results. Some tumors such as lymphomas cause
hypercalcemia through the presence of a 2 5- ( OH )-
vitamin D-1αa-hydroxylase enzyme that converts 2 5-
(OH)-vitamin D into 1,2 5- ( OH)
2
-vitamin ... diseases
and illustrates the concept that despite the underlying
Chapter 16 / The Pineal Hormone (Melatonin) 255
255
From: Endocrinology: Basic and Clinical Pri...
Endocrinology Basic and Clinical Principles - part 7 ppsx
... (1[OH ]-2 4, 25, 26,2 7-
tetranor-23-COOH-D) or 1, 25( OH)
2
D-26,23-lactone.
24, 25( OH)
2
D can also be metabolized by two pathways
leading to either 25, 26,27-trinor-24-COOH-D or 24,
25, 26,27-tetranor-23-COOH-D.
2.1.4. ... of
L-thyroxine (T
4
) and its major metabolites, T
3
and reverse T
3
(rT
3
). The enzymes include type I 5 -deiodinase (D1),
type II 5 -deiodinase (D2), a...
Endocrinology Basic and Clinical Principles - part 8 pdf
... variety of cytokines and growth fac-
tors (including interleukin-1α [IL-α] and IL-β, tumor
necrosis factor-α [TNF-α], and transforming growth
factor [TGF-β], as well as ANP and BNP) can stimulate
CNP ... natri-
uretic peptide receptor-A (NPR-A) and NPR-B. A third
receptor subtype, called the clearance receptor or NPR-
C, shares approx 30% homology with NPR-A and NPR-
B in the extr...
Endocrinology Basic and Clinical Principles - part 9 pot
... Sequence
Ang I Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
Ang II Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
Ang III Arg-Val-Tyr-Ile-His-Pro-Phe
Ang IV Val-Tyr-Ile-His-Pro-Phe
Ang 1-7 Asp-Arg-Val-Tyr-Ile-His-Pro
Chapter ... 3 1- to 36-kDa pre-
prohormone, from which seven mature peptide hor-
mones (adrenocorticotropic hormone, α-MSH, β-MSH,
γ-MSH, corticotropin-like intermediate lobe peptide,
β-lipotro...
Endocrinology Basic and Clinical Principles - part 10 ppsx
... causing 5 of 33 subjects to drop
out.
In a 26-wk randomized, double-blind, placebo-con-
trolled parallel-group trial in healthy elderly men and
women, the effects of GH and/ or sex steroids (test-
osterone ... 80
coregulators, 69, 70
dimerization, 56
domains,
DNA-binding domain, 55
ligand-binding domain, 55
overview, 68, 69
forms, 54 , 69, 72–74
mutations, 63
nuclear localization...