Endocrinology Basic and Clinical Principles - part 5 pptx
Endocrinology Basic and Clinical Principles - part 5 pptx
... the gene, including the 39-amino-acid adrenocorticotropin (ACTH), α-mel- anocyte-stimulating hormone (α-MSH), β-MSH,β-lipo- tropin (β-LPH), β-endorphin, and corticotropin-like intermediate lobe ... somatostatin, and do not require iv administration. The best-studied among these analogs is octreotide (D-Phe-Cys-Phe-D-Trp- Lys-Thr-Cys-Thr[ol]), which is currently used exten- sively in neuro...
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Endocrinology Basic and Clinical Principles - part 4 pptx
... Consequently, the primary androgens produced by the immature rat testes are androstenedione, 5 α-androstanediol, and 5 α-dihydrotestosterone. After d 40 of age, 5 α-reduc- tase activity decreases, and because ... corpus luteum, which secretes progesterone, 20α-hydroxy- 4-pregnen-3-one, pregnenolone, 17β-hydroxypro- gesterone, 4-androstenedione, estrone, and estradiol. In bovine a...
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Endocrinology Basic and Clinical Principles - part 1 ppsx
... 1 -5 882 9-4 2 7-7 (alk. paper) eISBN 1 -5 9 25 9-8 2 9-3 1. Endocrinology. 2. Hormones. 3. Endocrine glands—Diseases. I. Melmed, Shlomo. II. Conn, P. Michael. QP187.E 555 20 05 612.4—dc22 2004018638 32 Part ... of TGF-β class. ENDOCRINOLOGY v Endocrinology: Basic and Clinical Principles, Sec- ond Edition aims to provide a comprehensive knowl- edge base for the app...
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Endocrinology Basic and Clinical Principles - part 2 pdf
... PRL) The GH and PRL receptors belong to a large super- family of receptors that include the cytokine receptors for interleukin-2 (IL-2), IL-3, IL-4, IL -5 , IL-6, IL-7, IL-9, IL-11, IL-12, erythropoietin, ... sequester and prevent steroids from being metabolized and/ or cleared from the blood- stream. SHBG binds DHT with high affinity (k d ~ 0 .5 nM) and testosterone and E 2 with ap...
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Endocrinology Basic and Clinical Principles - part 3 pot
... Prostaglandins and Leukotrienes 93 93 From: Endocrinology: Basic and Clinical Principles, Second Edition (S. Melmed and P. M. Conn, eds.) © Humana Press Inc., Totowa, NJ 7 Prostaglandins and Leukotrienes Locally ... suppress- ing cell-mediated immunity (T-cell). EAE, collagen- induced arthritis and AA are all considered to be primarily T-cell-mediated disease models. Testoster...
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Endocrinology Basic and Clinical Principles - part 6 pps
... hypercalce- mia results. Some tumors such as lymphomas cause hypercalcemia through the presence of a 2 5- ( OH )- vitamin D-1αa-hydroxylase enzyme that converts 2 5- (OH)-vitamin D into 1,2 5- ( OH) 2 -vitamin ... diseases and illustrates the concept that despite the underlying Chapter 16 / The Pineal Hormone (Melatonin) 255 255 From: Endocrinology: Basic and Clinical Pri...
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Endocrinology Basic and Clinical Principles - part 7 ppsx
... (1[OH ]-2 4, 25, 26,2 7- tetranor-23-COOH-D) or 1, 25( OH) 2 D-26,23-lactone. 24, 25( OH) 2 D can also be metabolized by two pathways leading to either 25, 26,27-trinor-24-COOH-D or 24, 25, 26,27-tetranor-23-COOH-D. 2.1.4. ... of L-thyroxine (T 4 ) and its major metabolites, T 3 and reverse T 3 (rT 3 ). The enzymes include type I 5 -deiodinase (D1), type II 5 -deiodinase (D2), a...
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Endocrinology Basic and Clinical Principles - part 8 pdf
... variety of cytokines and growth fac- tors (including interleukin-1α [IL-α] and IL-β, tumor necrosis factor-α [TNF-α], and transforming growth factor [TGF-β], as well as ANP and BNP) can stimulate CNP ... natri- uretic peptide receptor-A (NPR-A) and NPR-B. A third receptor subtype, called the clearance receptor or NPR- C, shares approx 30% homology with NPR-A and NPR- B in the extr...
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Endocrinology Basic and Clinical Principles - part 9 pot
... Sequence Ang I Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu Ang II Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Ang III Arg-Val-Tyr-Ile-His-Pro-Phe Ang IV Val-Tyr-Ile-His-Pro-Phe Ang 1-7 Asp-Arg-Val-Tyr-Ile-His-Pro Chapter ... 3 1- to 36-kDa pre- prohormone, from which seven mature peptide hor- mones (adrenocorticotropic hormone, α-MSH, β-MSH, γ-MSH, corticotropin-like intermediate lobe peptide, β-lipotro...
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Endocrinology Basic and Clinical Principles - part 10 ppsx
... causing 5 of 33 subjects to drop out. In a 26-wk randomized, double-blind, placebo-con- trolled parallel-group trial in healthy elderly men and women, the effects of GH and/ or sex steroids (test- osterone ... 80 coregulators, 69, 70 dimerization, 56 domains, DNA-binding domain, 55 ligand-binding domain, 55 overview, 68, 69 forms, 54 , 69, 72–74 mutations, 63 nuclear localization...
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