Endocrinology Basic and Clinical Principles - part 4 pptx
Endocrinology Basic and Clinical Principles - part 4 pptx
... corpus luteum, which secretes progesterone, 20α-hydroxy- 4- pregnen-3-one, pregnenolone, 17β-hydroxypro- gesterone, 4- androstenedione, estrone, and estradiol. In bovine and ovine corpora lutea, although large ... steroidogenesis are exemplified, on the one hand, by the bovine corpus luteum, which secretes progesterone, 20β-hydroxy -4 - pregnen-3-one, and preg- nenolone, and on the...
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Endocrinology Basic and Clinical Principles - part 5 pptx
... the gene, including the 39-amino-acid adrenocorticotropin (ACTH), α-mel- anocyte-stimulating hormone (α-MSH), β-MSH,β-lipo- tropin (β-LPH), β-endorphin, and corticotropin-like intermediate lobe ... somatostatin, and do not require iv administration. The best-studied among these analogs is octreotide (D-Phe-Cys-Phe-D-Trp- Lys-Thr-Cys-Thr[ol]), which is currently used exten- sively in neuro...
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Endocrinology Basic and Clinical Principles - part 1 ppsx
... of TGF-β class. ENDOCRINOLOGY v Endocrinology: Basic and Clinical Principles, Sec- ond Edition aims to provide a comprehensive knowl- edge base for the applied and clinical science of endocrinology. ... Cataloging-in-Publication Data Endocrinology : basic and clinical principles / edited by Shlomo Melmed, P. Michael Conn.— 2nd ed. p. cm. Includes bibliographical ref...
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Endocrinology Basic and Clinical Principles - part 2 pdf
... PRL) The GH and PRL receptors belong to a large super- family of receptors that include the cytokine receptors for interleukin-2 (IL-2), IL-3, IL -4 , IL-5, IL-6, IL-7, IL-9, IL-11, IL-12, erythropoietin, ... colony-stimulating factor, interferon-β (IFN-β), IFN-γ, and CNTF. Many of these receptors are heterodimers consisting of an α-ligand-binding subunit and a β-signaling subunit. Howe...
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Endocrinology Basic and Clinical Principles - part 3 pot
... Prostaglandins and Leukotrienes 93 93 From: Endocrinology: Basic and Clinical Principles, Second Edition (S. Melmed and P. M. Conn, eds.) © Humana Press Inc., Totowa, NJ 7 Prostaglandins and Leukotrienes Locally ... suppress- ing cell-mediated immunity (T-cell). EAE, collagen- induced arthritis and AA are all considered to be primarily T-cell-mediated disease models. Testoster...
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Endocrinology Basic and Clinical Principles - part 6 pps
... (BMI >38 kg/m 2 ). PPAR-γ exists as two isoforms, PPAR- -1 and -2 , derived by alternate pro- moter usage, and much interest has focused on a poly- morphism in the PPAR- -2 gene that is exclusively expressed ... hypercalce- mia results. Some tumors such as lymphomas cause hypercalcemia through the presence of a 2 5-( OH )- vitamin D-1αa-hydroxylase enzyme that converts 2 5...
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Endocrinology Basic and Clinical Principles - part 7 ppsx
... (1[OH ]-2 4, 25,26,2 7- tetranor-23-COOH-D) or 1,25(OH) 2 D-26,23-lactone. 24, 25(OH) 2 D can also be metabolized by two pathways leading to either 25,26,27-trinor- 2 4- COOH-D or 24, 25,26,27-tetranor-23-COOH-D. 2.1 .4. ... thyrotropin and free T 4 and free T 3 . Total T 4 and T 3 levels are abnormal but are rarely measured in the clinical setting. 4. 2. Measurement of T...
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Endocrinology Basic and Clinical Principles - part 8 pdf
... variety of cytokines and growth fac- tors (including interleukin-1α [IL-α] and IL-β, tumor necrosis factor-α [TNF-α], and transforming growth factor [TGF-β], as well as ANP and BNP) can stimulate CNP ... IR tyrosine kinase are adapter protein Src-homology-collagen-like protein (SHC) and multifunctional docking proteins IRS-1 and IRS-2 (Fig. 4) . Tyrosine-phosphorylated SHC recrui...
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Endocrinology Basic and Clinical Principles - part 9 pot
... Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu Ang II Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Ang III Arg-Val-Tyr-Ile-His-Pro-Phe Ang IV Val-Tyr-Ile-His-Pro-Phe Ang 1-7 Asp-Arg-Val-Tyr-Ile-His-Pro Chapter 24 ... 3 1- to 36-kDa pre- prohormone, from which seven mature peptide hor- mones (adrenocorticotropic hormone, α-MSH, β-MSH, γ-MSH, corticotropin-like intermediate lobe peptide, β-lipotrophin, and...
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Endocrinology Basic and Clinical Principles - part 10 ppsx
... 203 deficiency, 2 04, 239 gigantism, 238 Laron dwarfism, 2 04 receptor, mutation and resistance, 24, 2 04, 239 signaling, 23, 24, 44 , 45 structure, 203, 2 04 replacement therapy, 42 6, 42 7 secretion, ... 396, 397 functions, 1 74 gene, 1 74 male reproduction role, 60, 40 5, 40 6, 41 3, 41 4 neuron embryology and immunocytochemistry, 176 precocious puberty pathophysiology, 24...
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