Basic medical endocrinology - part 5 pps
Basic medical endocrinology - part 5 pps
... of effects of 194 Chapter 5. The Pancreatic Islets -S-S- -S-S -S-S- COOH COOH insulin binding domain tyrosine kinase domain membane α-subunits β-subunits NH 2 NH 2 - Figure 18 Model of the insulin ... volume (᭹) and ADH in plasma of unanes- thetized rats. (From Dunn et al., J. Clin. Invest. 52 , 3212, 1973, with permission.) 50 40 45 35 30 25 20 15 10 5 0 051 0 15 20 percen...
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Basic medical endocrinology - part 1 ppsx
... receptor, restoring the resting state (I). Biosynthesis of Hormones 13 5& apos; 3' 12 3 4 5 12 312 4 5 primary RNA transcript 24 5 2 323 45 N C NC 12 3 4 5 alternatively spliced messenger RNAs NC primary protein ... Introduction transcription factors and cofactors pre-mRNA splicing mRNA introns start Pll terminate exons general transcription complex 12 34 5 AAAAAAA 12 34 5...
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Basic medical endocrinology - part 6 ppsx
... 2 5- hydroxylated precursor and binds less tightly than 2 5- OHD 3 to vitamin D- binding globulin. Consequently, 1, 25( OH) 2 D 3 has a half-life in blood of 15 hours, compared to 15 days for 2 5- OHD 3 . PHYSIOLOGICAL ... from Khosla, S., Endocrinology 124, 50 50 50 55, 2001, by permission of The Endocrine Society.) RANK RANK RANKL soluble RANKL RANK M-CSF osteoblastic cell c-Fms oste...
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Basic medical endocrinology - part 2 doc
... Hormones 47 H-Ab H-Ab H-Ab H-Ab H-Ab H-Ab Ab Ab Ab Ab H H H H H H H H H + H H-Ab H-Ab H-Ab H-Ab H-Ab H-Ab Ab Ab Ab Ab H H H H H H H H H + H H H H H H H H-Ab H-Ab H-Ab H-Ab H-Ab H-Ab H-Ab Ab Ab Ab Ab H H H H H H + H Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab A 10 0 101 0 20 40 60 80 100 55 0330 hormone ... into α-melanocyte-stimulating hormone (α-MSH) and the corticotropin-like intermediate...
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Basic medical endocrinology - part 3 docx
... Glands C=O CH 2 OH CH 2 OH HO HO - - - cortisol (active) O C=O O cortisone (inactive) HSD I HSD II HSD I O HO - - - Figure 5 The cortisol/cortisone shuttle. Two isoenzymes of 11-hyrdoxysteroid dehydrogenase (HSD ... a-pregnenolone dehydroepiandrosteronepregnenolone O C=O CH 3 OH O C=O CH 3 O O P 450 c17P 450 c17 17 a-progesterone androstenedioneprogesterone O C=O CH 2 O...
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Basic medical endocrinology - part 4 docx
... cell s glicentin IP2GLP-1 GLP-2 3 3-6 1 Figure 2 Cell-specific posttranslational processing of preproglucagon. GRPP, Glicentin-related pancreatic peptide; GLP-1, glucagon-like peptide 1; GLP-2, glucagon-like peptide ... fructose-1, 6-bisphosphate, is formed from fructose-6-phosphate by the action of an unusual bifunctional enzyme that catalyzes either phosphorylation of fructose-6-phosphate...
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Basic medical endocrinology - part 7 pot
... 1.2 Postabsorptive 90 15 100 120 — 1. 15 Day 1 80 10–12 120 120 5. 4 1. 15 Day 3 70 8 150 110 — 0.70 Day 5 70 7 150 110 6.1 0.60 a Values for GH are from Ho et al., J. Clin. Invest. 81, 968–9 75 (1988), and ... blood Ca 2+ ↓ blood Ca 2+ PTH ↓ blood phosphate 7-dehydrocholesterol diet vitamin D 3 24, 25 (OH) 2 D 3 1, 25 (OH) 2 D 3 25 OH-D 3 Figure 16 Regulation of 1α, 2 5- dihydro...
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Basic medical endocrinology - part 8 pot
... of Growth 3 2 1 0 -1 20 15 10 5 0 -5 -1 0 0 300 200 100 0 -1 00 nitrogen gm potassium mEq phosphorus mg sodium mEq control hGH 5 mg 10 days control hGH 10 mg 5 days control hGH 2 .5 mg 10 days hGH long term Figure ... (cm) 130 120 110 100 90 80 01020 days days 15 µg GH +0. 05 mg cortisone 15 µg GH +0.1 mg cortisone 15 µg GH +0 .5 mg cortisone 15 µg GH +1.0 m...
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Basic medical endocrinology - part 9 pptx
... Chapter 12. The Menstrual Cycle 0 5 10 15 0-7 -1 4 7 14 FSH mlU/ml LH mlU/ml 40 30 20 10 0 estradiol pmol/L 0 0 .5 1.0 1 .5 progesterone pmol/ml 50 40 30 20 10 0 200 150 100 50 0 80 60 40 20 0 inhibin A pg/ml inhibin ... by P 450 scc between carbons 21 and 22 gives rise to 21-carbon progestins. Removal of carbons 20 and 21 by the two-step reaction catalyzed by P 450 c17 (17α-h...
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Basic medical endocrinology - part 10 pdf
... 2 75 276 transcript splicing, 276–277 Calcitonin gene-related peptide, 276–277 Calcium absorption, 258 – 259 balance and deviation effects, 256 – 257 body distribution, 257 – 258 bone physiology, 259 –2 65 calmodulin ... 378–403. Suggested Reading 455 + 200 150 100 50 10 20 30 birth weeks of gestation prolactin hPRL (ng/ml) maternal plasma fetal plasma n=36n=4 n=32 normals (5 -...
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