Basic medical endocrinology - part 3 docx

... receptors Ca 2+ Ca 2+ TRHR TRH PIP2 TSH-α mRNA TSH-β mRNA TRHR TRHR (-) (-) preTSH secretory vesicles TSH golgi apparatus processing (+) (+) (+) nucleus thyrotrope PKC DAG + IP 3 T4 T3 T4 T3 down-regulation TRHR ... Glands C=O CH 2 OH CH 2 OH HO HO - - - cortisol (active) O C=O O cortisone (inactive) HSD I HSD II HSD I O HO - - - Figure 5 The cortisol/cortisone s...

Ngày tải lên: 10/08/2014, 18:21

... cell s glicentin IP2GLP-1 GLP-2 3 3- 6 1 Figure 2 Cell-specific posttranslational processing of preproglucagon. GRPP, Glicentin-related pancreatic peptide; GLP-1, glucagon-like peptide 1; GLP-2, glucagon-like peptide ... interleukins (IL-1 through IL-18), tumor necrosis factor (TNF), the interferons (IFN-α ,- , and - ), colony-stimulating factor (CSF), granulocyte/macrophage colony-sti...

Ngày tải lên: 10/08/2014, 18:21

... patients Affectives Schizo Neurotics Total Retarded activity 12 13 5 30 No retarded activity 18 17 25 60 Total 30 30 30 30 The analysis of such two-dimensional tables generally involves testing for the independence ... colour Eye colour Fair Red Medium Dark Black Light 688 116 584 188 4 Blue 32 6 38 241 110 3 Medium 34 3 84 909 412 26 Dark 98 48 4 03 681 81 The points representi...

Ngày tải lên: 10/08/2014, 15:20

... phos- phatidylinositol -3 (PI -3 ) kinase, which catalyzes the phosphorylation of carbon 3 of the inositol of phosphatidylinositol bisphosphate in cell membranes to form phosphatidylinositol 3, 4,5-trisphosphate ... receptor, restoring the resting state (I). Biosynthesis of Hormones 13 5' 3& apos; 12 3 4 5 12 31 2 4 5 primary RNA transcript 24 5 2 32 3 45 N C NC 12 3 4 5 alte...

Ngày tải lên: 10/08/2014, 18:21

... Hormones 47 H-Ab H-Ab H-Ab H-Ab H-Ab H-Ab Ab Ab Ab Ab H H H H H H H H H + H H-Ab H-Ab H-Ab H-Ab H-Ab H-Ab Ab Ab Ab Ab H H H H H H H H H + H H H H H H H H-Ab H-Ab H-Ab H-Ab H-Ab H-Ab H-Ab Ab Ab Ab Ab H H H H H H + H Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab Ab A 10 0 101 0 20 40 60 80 100 55 033 0 hormone ... into α-melanocyte-stimulating hormone (α-MSH) and the corticotropin-like intermediate...

Ngày tải lên: 10/08/2014, 18:21

... of 194 Chapter 5. The Pancreatic Islets -S-S- -S-S -S-S- COOH COOH insulin binding domain tyrosine kinase domain membane α-subunits β-subunits NH 2 NH 2 - Figure 18 Model of the insulin receptor. Regulation ... hepatic action to increase Reinforcement 209 Insulin 191 glycogen glucose-1-P I glucose-6-Pglucose II fructose-6-P fructose-1,6-P III hexose monophosphate shunt PEP pyruvate IV a...

Ngày tải lên: 10/08/2014, 18:21

... cytosol from CO 2 and water. Na + Na + 3Na + (+) (+) 2K + AII interstitiumlumen H + + HCO 3 - H 2 O + CO 2 H 2 CO 3 H 2 O H 2 CO 3 HCO 3 - 3HCO 3 - C0 2 H + IP 3 + DAG CO 2 General Features of ... Ed., p. 881, Saunders, Philadelphia, 1996, with permission.) N -1 0 -1 5 -2 0 +10 +20 +15 10 8 6 4 2 0 260 270 280 290 30 0 31 0 32 0 33 0 34 0 plasma osmolali...

Ngày tải lên: 10/08/2014, 18:21

... inadequacies Growth Hormone 32 9 0.0 10 20 30 40 50 60 70 80 90 100 prenatal -9 months til birth juvenile 1-1 2 years infantile birth -1 year adolescence ages 1 0-1 4 (girls) 1 2-1 6 (boys) stagepercent ... blood Ca 2+ ↓ blood Ca 2+ PTH ↓ blood phosphate 7-dehydrocholesterol diet vitamin D 3 24, 25 (OH) 2 D 3 1, 25 (OH) 2 D 3 25 OH-D 3 Figure 16 Regulation of 1α,25-di...

Ngày tải lên: 10/08/2014, 18:21

... IGFs in blood. IGFBP -3 , whose synthesis is stimulated by GH, IGF-I, and insulin, is the most abundant form and is complexed with most of the IGF-I and IGF-II in plasma. IGFBP -3 and its cargo of ... channels SSTR somatotrope G-proteins Figure 13 Effects of growth hormone-releasing hormone (GHRH), insulin-like growth factor-I (IGF-I), and somatostatin (SST) on the somatotrope. IGF-IR, GHR...

Ngày tải lên: 10/08/2014, 18:21

... Chapter 12. The Menstrual Cycle HO C=O CH 3 C=O CH 3 C=O CH 3 pregnenolone C=O CH 3 progesterone O O OH HO 17 α-pregnenolone 17 α-pregesterone 3 HSD 3 HSD 3 HSD 17βHSD 17βHSD P450c17 P450c17 = O androstenedione O P450scc P450c17 HO = O dehydroepiandrosterone testosterone O H O H O = O HO HO estrone ... Physiol. Revs. 72, 731 –788. Dorrington, J. H, and Armstrong, D.T. (1979). Effec...

Ngày tải lên: 10/08/2014, 18:21