Basic medical endocrinology - part 3 docx
Basic medical endocrinology - part 3 docx
... receptors
Ca
2+
Ca
2+
TRHR TRH
PIP2
TSH-α mRNA
TSH-β mRNA
TRHR
TRHR
(-) (-)
preTSH
secretory
vesicles
TSH
golgi
apparatus
processing
(+)
(+)
(+)
nucleus
thyrotrope
PKC
DAG + IP
3
T4
T3
T4
T3
down-regulation
TRHR ... Glands
C=O
CH
2
OH
CH
2
OH
HO
HO
- - -
cortisol (active)
O
C=O
O
cortisone (inactive)
HSD I
HSD II
HSD I
O
HO
- - -
Figure 5 The cortisol/cortisone s...
Basic medical endocrinology - part 4 docx
... cell
s
glicentin IP2GLP-1 GLP-2
3 3- 6 1
Figure 2 Cell-specific posttranslational processing of preproglucagon. GRPP, Glicentin-related
pancreatic peptide; GLP-1, glucagon-like peptide 1; GLP-2, glucagon-like peptide ... interleukins (IL-1
through IL-18), tumor necrosis factor (TNF), the interferons (IFN-α ,- , and - ),
colony-stimulating factor (CSF), granulocyte/macrophage colony-sti...
MEDICAL STATISTICS - PART 3 docx
... patients
Affectives Schizo Neurotics Total
Retarded activity 12 13 5 30
No retarded activity 18 17 25 60
Total 30 30 30 30
The analysis of such two-dimensional tables generally involves testing for the
independence ... colour
Eye colour Fair Red Medium Dark Black
Light 688 116 584 188 4
Blue 32 6 38 241 110 3
Medium 34 3 84 909 412 26
Dark 98 48 4 03 681 81
The points representi...
Basic medical endocrinology - part 1 ppsx
... phos-
phatidylinositol -3 (PI -3 ) kinase, which catalyzes the phosphorylation of carbon 3
of the inositol of phosphatidylinositol bisphosphate in cell membranes to form
phosphatidylinositol 3, 4,5-trisphosphate ... receptor,
restoring the resting state (I).
Biosynthesis of Hormones 13
5' 3& apos;
12 3 4 5 12 31 2 4 5
primary RNA transcript
24 5 2 32 3 45
N
C
NC
12 3 4 5
alte...
Basic medical endocrinology - part 2 doc
... Hormones 47
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
Ab
Ab
Ab
Ab
H
H
H
H
H
H
H
H
H
+
H
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
Ab
Ab
Ab
Ab
H
H
H
H
H
H
H
H
H
+
H
H
H
H
H
H
H
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
Ab
Ab
Ab
Ab
H
H
H
H
H
H
+
H
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
A
10
0
101
0
20
40
60
80
100
55 033 0
hormone ... into
α-melanocyte-stimulating hormone (α-MSH) and the corticotropin-like intermediate...
Basic medical endocrinology - part 5 pps
... of
194 Chapter 5. The Pancreatic Islets
-S-S-
-S-S
-S-S-
COOH
COOH
insulin binding domain
tyrosine kinase domain
membane
α-subunits
β-subunits
NH
2
NH
2
-
Figure 18 Model of the insulin receptor.
Regulation ... hepatic action to increase
Reinforcement 209
Insulin 191
glycogen
glucose-1-P
I
glucose-6-Pglucose II
fructose-6-P
fructose-1,6-P
III
hexose
monophosphate
shunt
PEP
pyruvate
IV
a...
Basic medical endocrinology - part 6 ppsx
... cytosol from CO
2
and water.
Na
+
Na
+
3Na
+
(+)
(+)
2K
+
AII
interstitiumlumen
H
+
+ HCO
3
-
H
2
O + CO
2
H
2
CO
3
H
2
O
H
2
CO
3
HCO
3
-
3HCO
3
-
C0
2
H
+
IP
3
+ DAG
CO
2
General Features of ... Ed., p. 881, Saunders, Philadelphia, 1996, with permission.)
N
-1 0
-1 5
-2 0
+10
+20
+15
10
8
6
4
2
0
260 270 280 290 30 0 31 0 32 0 33 0 34 0
plasma osmolali...
Basic medical endocrinology - part 7 pot
... inadequacies
Growth Hormone 32 9
0.0
10
20
30
40
50
60
70
80
90
100
prenatal
-9 months
til birth
juvenile
1-1 2 years
infantile
birth -1 year
adolescence
ages 1 0-1 4 (girls)
1 2-1 6 (boys)
stagepercent ... blood
Ca
2+
↓ blood
Ca
2+
PTH
↓ blood
phosphate
7-dehydrocholesterol
diet
vitamin D
3
24, 25 (OH)
2
D
3
1, 25 (OH)
2
D
3
25 OH-D
3
Figure 16 Regulation of 1α,25-di...
Basic medical endocrinology - part 8 pot
... IGFs in blood.
IGFBP -3 , whose synthesis is stimulated by GH, IGF-I, and insulin, is the most
abundant form and is complexed with most of the IGF-I and IGF-II in plasma.
IGFBP -3 and its cargo of ...
channels
SSTR
somatotrope
G-proteins
Figure 13 Effects of growth hormone-releasing hormone (GHRH), insulin-like growth factor-I
(IGF-I), and somatostatin (SST) on the somatotrope. IGF-IR, GHR...
Basic medical endocrinology - part 9 pptx
... Chapter 12. The Menstrual Cycle
HO
C=O
CH
3
C=O
CH
3
C=O
CH
3
pregnenolone
C=O
CH
3
progesterone
O
O
OH
HO
17 α-pregnenolone 17 α-pregesterone
3 HSD
3 HSD
3 HSD
17βHSD
17βHSD
P450c17
P450c17
=
O
androstenedione
O
P450scc
P450c17
HO
=
O
dehydroepiandrosterone
testosterone
O
H
O
H
O
=
O
HO
HO
estrone ... Physiol. Revs. 72, 731 –788.
Dorrington, J. H, and Armstrong, D.T. (1979). Effec...
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