Basic medical endocrinology - part 1 ppsx
Basic medical endocrinology - part 1 ppsx
... threatened
detector
hormone
response
hormone
degrading
apparatus
10 Chapter 1. Introduction
O
CH
2
O - P=O
O
O
CH
3
O
HN
N
O
Thymine
O
CH
2
O - P=O
O
O
O
O
CH
2
O - P=O
O
O
O
O
CH
2
O - P=O
O
O
O
O
CH
2
O - P=O
O
O
O
O
O
N
N
N
N
NH
2
Adenine
O
HN
N
N
N
H
2
N
Guanine
N
NH
2
O
N
Cytosine
O ... the
12 Chapter 1. Introduction
transcription
factors and
cofactors
pre-mRNA
sp...
Basic medical endocrinology - part 6 ppsx
... 279
2345678 910 11 12 13 14 15 16 17 18
undetectable
undetectable
calcitonin (pg/ml)
PTH (pg/ml)
4,000
3,000
2,000
1, 000
700
600
500
400
300
200
plasma calcium (m
g
/10 0 ml)
PTH
CT
Figure 13 Concentrations ... Berl,T., In “The
Kidney,” 5th Ed., p. 8 81, Saunders, Philadelphia, 19 96, with permission.)
N...
Basic medical endocrinology - part 2 doc
... Hormones 47
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
Ab
Ab
Ab
Ab
H
H
H
H
H
H
H
H
H
+
H
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
Ab
Ab
Ab
Ab
H
H
H
H
H
H
H
H
H
+
H
H
H
H
H
H
H
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
H-Ab
Ab
Ab
Ab
Ab
H
H
H
H
H
H
+
H
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
Ab
A
10
0
10 1
0
20
40
60
80
10 0
550330
hormone ... into
α-melanocyte-stimulating hormone (α-MSH) and the corticotropin-like intermed...
Basic medical endocrinology - part 3 docx
... inhibition.
11 8 Chapter 4. Adrenal Glands
HO
C=O
CH
3
OH
HO
C=O
CH
3
HO
O
P450c17P450c17
17 a-pregnenolone
dehydroepiandrosteronepregnenolone
O
C=O
CH
3
OH
O
C=O
CH
3
O
O
P450c17P450c17
17 a-progesterone
androstenedioneprogesterone
O
C=O
CH
2
OH
OH
O
OO
O
O
HO ... HO
HO
HC
C=O
CH
2
OH
11 -deoxycortisol
11 -deoxycorticosterone
C=O
CH
2
OH
OH
C=O
CH
2
OH
cortisol
corticosterone
C=O
CH
2
O...
Basic medical endocrinology - part 4 docx
... cell
s
glicentin IP2GLP -1 GLP-2
3 3-6 1
Figure 2 Cell-specific posttranslational processing of preproglucagon. GRPP, Glicentin-related
pancreatic peptide; GLP -1 , glucagon-like peptide 1; GLP-2, glucagon-like peptide ... fructose -1 ,
6-bisphosphate, is formed from fructose-6-phosphate by the action of an unusual
bifunctional enzyme that catalyzes either phosphorylation of fructose-6-...
Basic medical endocrinology - part 5 pps
... expression of effects of
19 4 Chapter 5. The Pancreatic Islets
-S-S-
-S-S
-S-S-
COOH
COOH
insulin binding domain
tyrosine kinase domain
membane
α-subunits
β-subunits
NH
2
NH
2
-
Figure 18 Model of the ... or the hepatic action to increase
Reinforcement 209
Insulin 19 1
glycogen
glucose -1 - P
I
glucose-6-Pglucose II
fructose-6-P
fructose -1 , 6-P
III
hexose
monophosphate
shunt
PEP
py...
Basic medical endocrinology - part 7 pot
... (ng/ml
a
) T3 (ng/ml)
Postprandial 15 0 50 12 0 1. 9 1. 2
Postabsorptive 90 15 10 0 12 0 — 1. 15
Day 1 80 10 12 12 0 12 0 5.4 1. 15
Day 3 70 8 15 0 11 0 — 0.70
Day 5 70 7 15 0 11 0 6 .1 0.60
a
Values for GH are from ... 45, 15 11 15 15, 19 96, reprinted with permission from
The American Diabetes Association.)
baseline fasting refeeding
-3 6 -2 4 -1 2 0 12 24 36 4...
Basic medical endocrinology - part 8 pot
... Growth
3
2
1
0
-1
20
15
10
5
0
-5
-1 0
0
300
200
10 0
0
-1 00
nitrogen
gm
potassium
mEq
phosphorus
mg
sodium
mEq
control hGH 5 mg
10 days
control hGH
10 mg
5 days
control hGH 2.5 mg
10 days
hGH
long
term
Figure ... Chapter 11 . Hormonal Control of Reproduction in the Male
body weight (grams)
body length (cm)
13 0
12 0
11 0
10 0
90
80
010 20
days days
15 µg GH
+0.0...
Basic medical endocrinology - part 9 pptx
... α-pregesterone
3βHSD
3βHSD
3βHSD
17 βHSD
17 βHSD
P450c17
P450c17
=
O
androstenedione
O
P450scc
P450c17
HO
=
O
dehydroepiandrosterone
testosterone
O
H
O
H
O
=
O
HO
HO
estrone estradiol -1 7 β
1
2
3
5
7
8
9
10
11
12
13
14
15
16
17
18
19
HO
20
21
22
23
24
25
26
27
AB
CD
4
6
cholesterol
P450c17
CYP19
(aromatase)
CYP19
(aromatase)
OH
Figure 6 Biosynthesis of ... receptor.
416 Cha...
Basic medical endocrinology - part 10 pdf
... hormones
anatomy
cortex, 11 2 11 4
medulla, 15 6
blood supply, 11 4
functional overview, 11 2
histology, 11 3 11 4
medullary hormones, see Epinephrine;
Norepinephrine
Adrenergic receptors, types, 16 1 16 2
Adrenocorticotropic ... interactions,
13 9 14 1
cytokine interactions, 14 1 14 3
miscellaneous inflammatory mediator
inhibition, 14 4
overview, 13 7 13 9
lung development role, 13...