Hematologic Malignancies: Myeloproliferative Disorders - part 2 doc

... inv(3)(q21q26)/t(3; 3)(q21;q26), t(3; 21 )(q26;q 22) , t(7; 11)(p15; p15), t(8; 21 )(q 22; q 22) , and inv(16)(p13q 22) (Johansson et al. 20 02) . With regard to the phenotype of BC, cytogenetic evo- lution ... These include: 1p36, 1q 12 32, 3q21, 3q26, 7p15, 11q23, 12p13, 12q24, 13q14, 14q 32, 17p11–13, 17q10–11, 21 q 22, and 22 q10 (Johansson et al. 20 02) . A majority of the second-...

Ngày tải lên: 10/08/2014, 16:22

... Activated by Bcr-Abl 23 2. 5.1 Effects of Bcr-Abl on Signal Transduction 23 2. 5.1.1 RAS Pathway 23 2. 5.1 .2 MYC Pathway 24 2. 5.1.3 STAT Pathway 24 2. 5.1.4 Other Signaling Pathways . . 25 2. 5 .2 Impaired ... Health Hammersmith Hospital Bethesda, MD 20 8 92 Du Cane Road USA London W 12 0NN UK ISBN-10 3-5 4 0-3 450 5-1 Springer Berlin Heidelberg New York ISBN-13 97 8...

Ngày tải lên: 10/08/2014, 16:22

... RI Score 0 65 2 60 72 20 26 1 569 18 60 70 23 23 2 881 28 47 62 31 32 3 867 28 37 48 46 31 4 485 15 35 40 51 28 5 21 4719187141 6 57 2 16 22 73 32 7 4––––– 5-year probability of leukemia-free survival ... 100 =3.8% 2yr = 18.8% 33% at 3 yrs CP 43% at 3yrs 54% at 3 yrs CP1 60% at 3yrs (Ruiz-Arguelles et al. 20 05) 24 Bu/Cy/Fd 24 CP 24 Sib 41 yrs 18 /24 molecular remissio...

Ngày tải lên: 10/08/2014, 16:22

... Activation of p65 NF-kappaB protein by p210BCR-ABL in a myeloid cell line (P210BCR-ABL activates p65 NF-kappaB). Oncogene 15 :22 67– 22 75 Hannon GJ (20 02) RNA interference. Nature 418 :24 4 25 1 Harrington ... been gen- erated against HLA-A 020 1 and HLA-A24 0 2- restricted epitopes selectively kill WT1-expressing leukemia cells (Gao et al. 20 00, Ohminami et al 20 00). Anti-WT-1 an- tib...

Ngày tải lên: 10/08/2014, 16:22

... Wityak J, Borzilleri RM (20 04) Discovery of N- ( 2- chloro-6-methyl- phenyl )- 2- ( 6-( 4-( 2- hydroxyethyl)-piperazin-1-yl ) -2 -methylpyrimidin-4 yla- mino)thiazole-5-carboxamide (BMS-354 825 ), a dual Src/Abl ... BCR-ABL-Negative CML 22 0 13 .2 Mutated Tyrosine Kinases in BCR-ABL-Negative CML 22 0 13 .2. 1 Cytogenetic Abnormalities 22 0 13 .2. 2 PDGFRA Fusion Genes 22 1 13...

Ngày tải lên: 10/08/2014, 16:22

... Introduction 25 4 15 .2 Pathogenesis 25 4 15 .2. 1 Clonality 25 4 15 .2. 2 Cytogenetics 25 5 15 .2. 3 Molecular Studies 25 6 15 .2. 4 Role of Growth Factors 25 6 15 .2. 4.1 Platelet-Derived Growth Factor 25 6 15 .2. 4 .2 Transforming ... 26 7 15.7 .2 Surgery and Radiotherapy 26 7 15.7 .2. 1 Splenectomy 26 7 15.7 .2. 2 Radiotherapy 26 8 15.7.3 Stem Cell Transplantation 26 8 15.7...

Ngày tải lên: 10/08/2014, 16:22

... >400,000 2. Arterial O 2 saturation > 92% 2. Leukocytosis > 12, 000 3. Splenomegaly 3. Elevated vitamin B 12 or unbound B 12 binding capacity oxygen-sensing pathway (Ang et al. 20 02b). First re- ported ... Biol Chem 27 1: 322 53– 322 59 Huang LE, Gu J, Schau M, Bunn HF (1998) Regulation of hypoxia-indu- cible factor 1alpha is mediated by and oxygen-dependent degra- dation...

Ngày tải lên: 10/08/2014, 16:22

... pulmonary dysplasia 29 8 fibronectin 25 6 fibrosis 24 2 FIP1L1-PDGFRA 22 2, 23 5, 23 6, 24 0, 24 1, 24 5 FK506 94 FKBP- 12 94 flavopiridol 5 FLT 22 6 FLT3 22 6 fludarabine 124 , 26 8 fluorescence resonance energy ... mutations 3 02 erythrocytosis 27 8, 27 9, 28 1, 28 3, 304 – causes 28 4 erythromelalgia 28 5, 28 7, 322 , 326 , 327 erythropoiesis 26 3, 29 9 erythropoiet...

Ngày tải lên: 10/08/2014, 16:22

... Other Myeloproliferative Diseases (Part 2) Etiology The etiology of PV is unknown. Although nonrandom chromosome abnormalities such as 20 q, trisomy 8, and especially 9p, have been documented ... of the malignant clone express JAK2 V617F. Fifth, JAK2 V617F has been observed in patients with long-standing idiopathic erythrocytosis. However, while JAK2 V617F alone may not be suffi...

Ngày tải lên: 07/07/2014, 04:20

... waist-to-hip ratio 1 Self report or FPG > 140 mg/dL Placebo 2% metformin 0% 50 DPP > ;25 yo, BMI > ;24 , FPG 9 5-1 25 , 2h 14 0-1 99 2. 8 FPG> 126 , 2h> 20 0 standard lifestyle + placebo 28 .9 standard ... type 2 DM; IGT and IFG 3.3 2h > 20 0 placebo 41.5 acarbose 32. 4 11 TRIPOD >18 years old, gestational DM in the prior 4 years, and sum of IGT > 625 2. 5...

Ngày tải lên: 10/08/2014, 18:21