Blood Disorders in the Elderly - part 8 pps

... Pharma- cokinetics of 2-F-ara-A (9-beta-D-arabinofuranosyl- 2- uoroadenine) in cancer patients during the Phase I clinical investigation of fl udarabine phosphate. Semin Oncol 1990; 17: 18 32. 74. ... chain of ricin – and with two-chain immunotoxins consisting of ricin A and B chains but with the nonspecifi c galactose-binding sites of ricin blocked. These compounds have shown maj...

Ngày tải lên: 10/08/2014, 16:22

... assessment. In Blood Disorders of the Elderly we propose a novel look at aging. By identifying the in uence of aging on the development of blood disorders, and the in uence of these disorders on the ... of 88 % and specifi city of 93% (using cut- off value of 1.5) for detecting iron-defi ciency ane- mia in older adults when compared to the more defi nitive and p...

Ngày tải lên: 10/08/2014, 16:22

... impression. Denileukin diftitox (DAB 389 IL-2, Ontak, DD) is a cytotoxic fusion protein combining the enzy- matically active moiety of the diphtheria toxin to the receptor-binding domain of IL-2. It is currently ... expansion in these patients may Introduction Non-Hodgkin lymphoma (NHL) is a topic of increas- ing signifi cance in an aging population. According to the National Ca...

Ngày tải lên: 10/08/2014, 16:22

... whether they engaged in any of the following activities in the past two weeks High-intensity activities Moderate or light-intensity activities Swimming Gardening Hiking Mowing Anaerobics Raking Tennis ... on the other hand posits that individual cells are the targets of the aging process, via a time-dependent increase in homeostatic dysfunction. The potential mecha- nisms...

Ngày tải lên: 10/08/2014, 16:22

... placebo-controlled clinical study. J Am Geriatr Soc 1 989 ; 37: 1 8. 28. Gravenstein S, Drinka P, Duthie EH, et al. Effi cacy of an in uenza hemagglutinin-diphtheria toxoid conju- gate vaccine in elderly ... to the H3N2 vaccine strain were higher in the older than in the younger participants [16]. Therefore, the age-related immune-response change appears to be related to...

Ngày tải lên: 10/08/2014, 16:22

... recycling, storage, and utilization. Iron is excreted by shedding of intestinal and skin cells, and through minor blood loss in the intestine. In principle, the iron content of shed epithelial ... Orchiectomy increases bone marrow interleukin-6 lev- els in mice. Calcif Tissue Int 19 98; 62: 219–26. 70. Ershler WB, Keller ET. Age-associated increased inter- leukin-6 gene expre...

Ngày tải lên: 10/08/2014, 16:22

... antibody to IL-6 [ 28] . In cell mod- els TNF-α reduced the induction of DMT-1 in the enterocytes, thereby causing reduction in intestinal iron transport [83 ]. As mentioned above, cytokines also ... colony-forming units. The site of action of erythropoietin in the bone marrow is mainly on the late colony-forming unit (CFU-E) and through interaction with SCF and IL-3 on...

Ngày tải lên: 10/08/2014, 16:22

... by a pathway involving the NF-κB superfamily. Among these eleven NF-κB-regulated genes are apopto- sis inhibitor-2, tumor necrosis factor-α-induced protein 2, MAX protein, IL-6, nuclear factor ... [50,77, 78] , so this strategy remains investigational. However, because of the high preva- lence of the MDR1 phenotype in the elderly popu- lation, there is continued investigation...

Ngày tải lên: 10/08/2014, 16:22

... et al. The plas- minogen activator inhibitor- 1-6 75 4G/5G genotype in uences the risk of myocardial infarction associ- ated with elevated plasma proinsulin and insulin 484 Index vitamin B 12 ... healing and facili- tate reproduction. Hyperhomocysteinemia Homocysteine is a sulfur-containing amino acid, which results from the hydrolysis of S-adenosyl- homocysteine in the methi...

Ngày tải lên: 10/08/2014, 16:22

... brucellosis. In multiple sclerosis, chronic inflammatory changes can develop in the extreme periphery of the retina (pars planitis or intermediate uveitis). Figure 2 9-4 Retinal vasculitis, ... requires slit-lamp examination to identify inflammatory cells floating in the aqueous humor or deposited upon the corneal endothelium (keratic precipitates). Anterior uveitis de...

Ngày tải lên: 06/07/2014, 15:21