Blood Disorders in the Elderly - part 7 pps

... expansion in these patients may Introduction Non-Hodgkin lymphoma (NHL) is a topic of increas- ing signifi cance in an aging population. According to the National Cancer Institute’s SEER program, the ... about 30% [ 177 , 178 ]. Unfortunately, evi- dence that more intensive therapies such as CHOP are particularly benefi cial when used as initial treat- ment is weak [ 170 , 173 , 174...

Ngày tải lên: 10/08/2014, 16:22

... each individual, which can only be estimated on the basis of individual assessment. In Blood Disorders of the Elderly we propose a novel look at aging. By identifying the in uence of aging ... neutropenia in patients with intermediate-grade non- Hodgkin’s lymphoma receiving initial CHOP chemo- therapy: a risk factor analysis. Clin Lymphoma 2001; 2: 47 56. 13. Repetto L,...

Ngày tải lên: 10/08/2014, 16:22

... arabinosyl- 2- fl uoroadenine [73 ,74 ]. It is actively taken up by cells and phosphorylated to its 5 Ј -triphosphate, F-ara-ATP, which is the active form of the drug. F-ara-ATP inhib- its DNA synthesis ... chain of ricin – and with two-chain immunotoxins consisting of ricin A and B chains but with the nonspecifi c galactose-binding sites of ricin blocked. These compounds have sho...

Ngày tải lên: 10/08/2014, 16:22

... strains, we plot- ted the CAFC day -7 cycling data against the mean lifespan of the eight respective strains and found a striking inverse linear correlation of the two traits among all strains ... on the other hand posits that individual cells are the targets of the aging process, via a time-dependent increase in homeostatic dysfunction. The potential mecha- nisms inc...

Ngày tải lên: 10/08/2014, 16:22

... to the H3N2 vaccine strain were higher in the older than in the younger participants [16]. Therefore, the age-related immune-response change appears to be related to in uenza strain. The ... age-related decline in antibody response is accountable for the age-reduced vaccine effi cacy in elderly people. The most commonly used in uenza vaccine for elderly people is...

Ngày tải lên: 10/08/2014, 16:22

... recycling, storage, and utilization. Iron is excreted by shedding of intestinal and skin cells, and through minor blood loss in the intestine. In principle, the iron content of shed epithelial ... Orchiectomy increases bone marrow interleukin-6 lev- els in mice. Calcif Tissue Int 1998; 62: 219–26. 70 . Ershler WB, Keller ET. Age-associated increased inter- leukin-6 gene expr...

Ngày tải lên: 10/08/2014, 16:22

... ciency [73 ,74 ]. A second pro- posed mechanism involves the stimulatory effects of these same pro -in ammatory cytokines, particu- larly IL-6, on hepcidin level and activity [28 ,75 ,76 ]. The critical ... erythropoietin in the bone marrow is mainly on the late colony-forming unit (CFU-E) and through interaction with SCF and IL-3 on the burst-forming unit (BFU-E). Erythropoie...

Ngày tải lên: 10/08/2014, 16:22

... [50 ,77 ,78 ], so this strategy remains investigational. However, because of the high preva- lence of the MDR1 phenotype in the elderly popu- lation, there is continued investigation into the use ... days following the completion of chemo- therapy, and there has been no evidence of inferior clinical outcome [25,60, 67, 75 ,76 ]. With the use of G-CSF or GM-CSF following in...

Ngày tải lên: 10/08/2014, 16:22

... rHuEPO therapy 2 17 collagen 75 , 372 , 375 , 430 colony-forming units erythroid (CFU-E) 1 57 8, 2 07, 209, 216 granulocyte-macrophage (CFU-GM) 77 spleen (CFU-S) 75 , 76 colony-stimulating factors 1 67 8 comorbidity ... et al. The plas- minogen activator inhibitor- 1-6 75 4G/5G genotype in uences the risk of myocardial infarction associ- ated with elevated plasma proinsulin...

Ngày tải lên: 10/08/2014, 16:22

... environment, thereby preventing the destruction of cartilage and preventing the progression of OA. In the case of advanced- and terminal-stage OA, when there is no longer cartilage in the weight-bearing ... has originated in the bone marrow. If S-100 protein is used to stain the tissue, most cells stain positive, substantiating the fi nding that they are indeed chondrocy...

Ngày tải lên: 11/08/2014, 17:20