Statistical Methods in Medical Research - part 1 pptx
... Protocol departures, 606 18 .7 Data monitoring, 613 18 .8 Interpretation of trial results, 623 18 .9 Special designs, 627 18 .10 Meta-analysis, 6 41 19 Statistical methods in epidemiology, 648 19 .1 Introduction, ... 13 68 %70Á 319 Á97Á02Á60 19 9Á9 30±34 No. 16 15 430 14 3 58 8 2254 % 71 719 16 Á32Á60Á4 10 0 1 35±39 No. 789 338 66 27 6 12 26 %64Á427Á65Á42Á20Á5 10 0 1 40 ...
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... 2Á90 0Á0 41 0 10 4 A 13 1 18 61 23 1 14 1 14 0 13 3 0Á066 A 17 1 90 67 50 2Á04 2 11 0Á0 21 0Á030 B 10 2Á78 83 12 1 27 1 28 0 15 0 0Á095 B 11 2Á27 67 60 2 14 2Á22 0Á034 0Á053 B 12 1 74 84 10 0Á44 ... À2Á6 1 88 58 31 26Á05Á0 1 18 61 23 7Á 315 Á7 2Á08 68 22 23Á6 1 6 1 70 69 13 13 Á9 À0Á9 1 74 55 9 24Á8 15 Á8 1 90 67 50 20Á030Á0 1 79 67 12 17 Á4 À5Á4 2 11 68 11 24Á3...
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... 2Á33Á87 17 2 6Á756 1 256 77Á50 3Á85 2 90 3 227 43 5Á68 1 737 0Á37 21 2Á74Á69 363 10 Á6 61 1Á876 81 21 7Á68 3 12 9 7 81 19 4Á32 1 463 0Á 215 6 4Á66Á73 236 10 Á386 2Á403 12 1Á02 5Á67 4 412 32 299 13 1 5Á64 1 730 ... 0Á0720 13 Á 918 Á 81 1092 34Á047 8Á802 433Á76 22 17 8 499 19 462 56 3 18 1 15 7 0Á0747 13 Á 415 Á50 10 36 26Á973 8Á473 480Á50 17 Á 41 9 4 51 39 17 29 636 4Á...
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Statistical Methods in Medical Research - part 2 ppt
... Difference d i Patient Drug Placebo (drug À placebo) 11 922 À3 211 18 À7 314 17 À3 417 19 À2 52322 1 611 12 1 715 14 1 819 11 8 911 19 À8 10 8 7 1 13 basis of which he or she was given an `anxiety score' ... with continuity correction z Probability 0Á 510 5 1 5 81 2 !8 0Á0547 0Á0547 1 5 81 0Á0579 0 15 05 2 12 1 2 !8 0 11 17 0 12 21 1 17 9 0 11 92 0Á54020 3 16 2 14 !...
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Statistical Methods in Medical Research - part 3 ppsx
... by r L , r U y À gv 12 v 22 Æ t f , a S x 2 v 11 À 2yv 12 y 2 v 22 À g v 11 À v 2 12 v 22 ! 1 2 1 Àg , 5 :15 where 16 0 Analysing variances ^p p, the `hat' symbol indicating the ML estimator. Two ... to be 1 2 x 1 x 2 : Observed x 1 x 2 Expected 1 2 x 1 x 2 1 2 x 1 x 2 Applying the usual formula (4.30) for a x 2 statistic, we have X...
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Statistical Methods in Medical Research - part 4 pps
... protein Low protein 70 1 83 2 85 3 94 4 97 5 10 1 6 10 4 7 10 7 8Á5 10 7 8Á5 11 3 10 11 8 11 11 9 12 12 3 13 12 4 14 12 9 15 13 2 16 13 4 17 14 6 18 16 1 19 Sum of ranks T 2 14 0Á5 T 1 49Á5 n 2 12 n 1 ... 91 85 À 212 1922283438394449 617 6 94 11 310 1 319 25293035405267 10 1 18 À4 3 612 18222328334560 10 7 À24 10 À3 0 612 1 617 22273954 11 8 À35 À...
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Statistical Methods in Medical Research - part 6 pps
... DF Between-individuals stratum N À 1 Groups g À 1 Residual between individuals N À g Within-individuals stratum Nk À 1 Occasions k À 1 Occasions  groups g À 1 k À 1 Residual within individuals ... methods can be found in Goldstein (19 95, Chapter 4). 12 .6 Longitudinal data In many medical studies there is interest not only in observing a variable at a given instant...
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Statistical Methods in Medical Research - part 7 ppsx
... 43 48 18 3 41 44 39 39 16 3 346 Surviving 2 5 4 1 12 5 8 11 9 33 45 Total 51 48 47 49 19 5 46 52 50 48 19 6 3 91 Proportion killed 0Á9385 0Á8 316 0Á8849 15 .5 Other components of x 2 513 The log-linear ... severe) 22/26 0Á8462 15 / 21 0Á 714 3 II (least severe) 6 /11 0Á5455 4 /18 0Á2222 III (unknown) 1/ 1 1 0000 1/ 2 0Á5000 15 .6 Combination of 2 3 2 tables 519 Y b H 0 ...
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Statistical Methods in Medical Research - part 8 docx
... 4Á56 3Á29 22Á 41 3Á22 3Á29 32Á 41 2Á63 3Á29 42Á 41 2Á28 3Á29 52Á 41 2Á04 1 97 Sample size Terminal 15 5 13 0 12 6 Mean on H 0 15 1 12 9 12 6 Mean on H 1 1 01 103 11 3 18 .7 Data monitoring 619 Sequential ... day t j d j n H j q t j p t j l t j 0 Ð 19 Ð Ð 10 0Á0 6 1 19 0Á0526 0Á9474 94Á7 19 1 18 0Á0556 0Á9444 89Á5 32 1 17 0Á0588 0Á9 412 84Á2 42 2 16 0 12 50 0Á8750 73...
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Statistical Methods in Medical Research - part 10 docx
... 45678 910 111 213 1 415 40Á05 10 0Á 01 Ð 50Á05 11 17 0Á 01 Ð 15 60Á05 12 18 26 0Á 01 10 16 23 70Á05 13 20 27 36 0Á 01 10 16 24 32 80Á05 14 21 29 38 49 0Á 01 11 17 25 34 43 90Á05 14 22 31 40 51 62 0Á 01 11 18 ... 0Á05 18 27 37 48 60 73 88 10 3 11 9 13 6 0Á 01 13 22 31 41 53 65 79 93 10 9 12 5 14 0Á05 19 28 38 50 62 76 91 106 12 3 14 1 16 0 0Á 01 14 22...
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