... 2. Th 1 and Th 2 paradigmDifferentiated by Cytokines Produced FunctionTh1 IL- 12 IL -2 , IFN-γ cell mediated cytotoxicitysuppresses Th2-cellresponseTh2 IL-4 IL-4, Il-5, IL-6 suppresses Th1-cellresponseIL-10 ... Child-Turcotte-Pugh classification PointsVariable 1 2 3Encephalopathy None Moderate SevereAscites None Slight ModerateBilirubin (mg/dl) < ;2 2- 3 >3Albumin (g/dl) >3.5 2. 8-3 .5 < ;2. 8Prothrombin ... and Th2 paradigm. Precursor CD4 cells producing interleukin- 12 promote Th 1 cells, whereas precursor CD4 cells producing interleukin-4 (IL-4)promote Th2 cells.Th1 cells secrete IFN-γ, IL -2 , which...