báo cáo khoa học: "Innovation in mental health services: what are the key components of success?" pot

... about health and social care more broadly, andso are not limited to mental health. Taking both of the se points into consider ation, the findings will be dis-cussed now in terms of the main f ... obtained in the spring of 2008, and the evaluation was completed bysummer 2010.Results of the evaluation and discussion of the findings The findings summarised in this article represent the mainoutcomes ... processes are still not wellunderstood in the field of mental health. Here, weexamine innovations in mental health services in orderto progress an understanding of the barriers andenabling factors...

Báo cáo khoa học: Differences in substrate speciﬁcities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes potx

... role for the enzymes in the activation o f CPB in the parasite, as ProisthesecondaminoacidofthematuredomaininalloftheCPB isoenzymes for which the structure i s known. The variation of a mino a ... procedure.Incorporating mutations into the CPB3 gen e and intro-ducing the mutated genes into Dcpb by transfection a llowedan investigation into the functional roles of these aminoacids. The activity ... auto-processing of their pro-enzymes to active enzymes – Pro is the second amino acid in the mature form of the proteases[11,35]. The importance of S2¢–P2¢ interaction was furtherevidenced by the...

Báo cáo khoa học: "Asymmetry in Parsing and Generating with Unification Grammars: Case Studies From ELU" pot

... generating lies in the nature of the input. The text, as a string of words, traditionally establishes the starting point of parsing; whether the processing is top-down or bottom-up, the basis ... b. Fmd a non-chaining rule which can have the pivot as mother, similarly making sure that the FS resulting from the unification of the pivot and the mother can be linked up to the current FS. ... and (ii) the role of lexicalism. One aspect of non-detetmini.qm in generation, that of the ordering of role application, is partially overcome in FLU by the user specification of the bead...

báo cáo khoa học: "An attempt to modify allelic frequencies at the Adh locus of a Drosophila melanogaster population in a tropical environment" pot

... Due to the extraction of the F allele, both strains were inbred ; they were crossed before the experiment in order to improve their viability. The genotypes of the collected ... the low proportion of genetically-marked flies collected in the second sample at the end of the release period, in spite of the apparently favorable conditions for their ... the original population. Pooling the heterozygote data of these first two samples provided a more precise estimate of the frequency of the F allele (3.5 p. 100) in the...

Tài liệu Báo cáo khoa học: Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics pdf

... contains mainly13C8, whereas the squaresrepresent the distribution 1 Da higher. To determine the mass increase with increasing time of deamidation(pH 9.6), the best ﬁt of calculated intensity ... sites, such as the protonated side chains of basic residues, in solution are solvated out into the aqueous phase, while in the gas phase they are insteadsolvated onto the protein backbone, with ... expression are compared accurately by iso-topically labeling the proteins from one and compar-ing in their mixture the corresponding peaks of theirrespective peptides, usually differing by three...

Tài liệu Báo cáo khoa học: Oxidized elaﬁn and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3 pdf

... inhibition of Pr3 by the oxidized inhibitors.While the above data are in overall agreement with the results obtained using synthetic substrates, theyalso indicate that elastin hinders the inhibition ... that (a) the observed inhibition is lower than that with the theoretical inhibitor, regardless of the enzyme, the inhibitor and the state of oxidation of the latter, indi-cating that elastin does ... to inhibit NE and Pr3 in lung in ammation? The in vivo potency of a proteinase inhibitor dependsupon its in vivo concentration ([I]vivo) and the kineticconstants describing its inhibition of...

Báo cáo khoa học: Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage docx

... peroxynitrite(ONOO)). These ﬁndings indicate that the cysteineresidues exposed on the surface of proteins are the dominant intracellular thiol and that they may play animportant role in intracellular ... the intermembranespace and on the outer face of the inner membrane fromthose within the mitochondrial matrix. Because matrixprotein thiols are of the greatest interest as a result of Protein ... number of studies have investigated the intracellular abundance of protein thiols [2,5–8], little is known about the amount of exposed protein thiols within cells in comparison toGSH, or whether they...

Báo cáo khoa học: Nautilin-63, a novel acidic glycoprotein from the shell nacre of Nautilus macromphalus doc

... key role in binding chitin, and thus in participating in the structuring of the organic framework, at the same timeas ﬁnely interacting with the mineral phase. It is possi-ble that these two ... part of the polyanionic properties of N63 is a result of the acidic glycosyl moieties [38,39].Chitin-binding capability of N63Framework proteins of the organic nacre matrix are hypothesized to interact ... two functions are displayed sequentially(chitin-binding, followed by mineral interaction).We are fully aware that trying to decipher the func-tion of one single component of the nacre matrix...

Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

... over-lapping with the EGF-binding domain [32]. The structural constraints of the EGFR binding regionsupport a stochiometry of 1 : 1 for the decorin pro-tein core and EGFR, suggesting that decorin ... regulation of cell signalinghas not been studied in great detail. In analogy todecorin, lumican inhibits tumor cell growth in softagar by increasing the expression of the cyclin-depen-dent kinase inhibitor ... thereby explaining the anti-invasiveeffects of this SLRP [82]. A commonality of signalingbetween lumican and decorin is also supported byrecent studies showing the involvement of decorin in modulating...

Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

... cannot bindproMMP2, but the N-terminal region of TIMP-2 binds the catalytic domain of MT1-MMP inhibiting itsactivity, whereas its C-terminal domain binds to the hemopexin-like domain of Pro-MMP-2 ... catalytic zinc. Interactionbetween cysteine–zinc maintains proMMPs in an inac-tive state by preventing a water molecule from bindingto the zinc atom. All MMPs, with the exception of MMP-7, ... binding to its hemopexin domain, leaving the N-ter-minal fully capable of interacting with other MMPs.Most cell types secrete proMMP-9 in complex withTIMP-1, which complex can be found in the...

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