báo cáo khoa học: "CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: An updated meta-analysis and review" pdf

... AccessCYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: An updated meta-analysis and reviewPing Zhan1†, Qin Wang2†, Qian Qian1, Shu-Zhen Wei3 and Li-Ke Yu1*AbstractBackground: Many ... CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: An updated meta-analysis and review. Journal of Experimental & Clinical Cancer Research 2011 30:99.Submit your next manuscript ... MspI and exon7 gene polymorphisms and lung cancer risk, and performed the subgroup analysis stratified by ethnicity,histological types of lung caner, gender and smoking statusof case and control...

Báo cáo khóa học: Identiﬁcation of a gene encoding Lon protease from Brevibacillus thermoruber WR-249 and biochemical characterization of its thermostable recombinant enzyme pptx

... (45) and carbonicanhydrase (30); lanes 2 and 3, crude lysate from E. coli cells containingpET21a-Bt-Lon plasmid without and with isopropyl thiogalactosideinduction, respectively; lanes 4 and ... Switzerland).Insulin from bovine pancreas and dithiothreitol werepurchased from Sigma.DNA manipulation and sequence analysisPlasmid DNA preparation, puriﬁcation of DNA fromagarose gel, and restriction ... thermophilic and mesophilic organisms, thermophilicproteins contain more hydrophobic and charged aminoacids and fewer uncharged polar residues than mesophilicFig. 6. ATP dependence and substrate...

Báo cáo khoa học: "Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy" docx

... regional failures, and 8 distant metastases. Fivepatients showed local and regional failures, 7 showedregional and distant failures, and one patient showedlocal and distant failures. Of those ... the five-year survival and cause-specific survival rates of stage I and II oraltongue cancers as 60.9% and 83.5%, respectively, and inother oral cavity subsites as 64.7% and 94.1%, respec-tively, ... therapy.Survival and prognostic analysisThe median follow-up was 45 months (range: 4- 99months). The five-year OS and DFS rates were 80.8% and 80.2%, respectively (Figure 1). By univariate analysis,grade...

Báo cáo khoa học: "Large volume unresectable locally advanced nonsmall cell lung cancer: acute toxicity and initial outcome results with rapid arc" potx

... in solid tumor. European Organization forResearch and Treatment of Cancer, National Cancer Institute of theUnited State, National Cancer Institute of Canada. J Natl Cancer Inst 2000,92:205-216.29. ... local control and overall survival of58% and 58% respectively and a median survival time of25 months for patients with inoperable stage III lung cancer and treated with 70 Gy (range 60-90 Gy) ... outcome and late toxicity.Background Lung cancer remains the major cause of cancer- relatedmortality worldwide. Non-small cell lung cancer (NSCLC) account for at least 80% of all lung tumorsand...

Báo cáo khoa học: The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain pdf

... SNX9 and HA-tagged ubiqu-itin (UbHA) were transiently transfected into HEK293cells. The total pool of ubiquitylated proteins wasimmunoprecipitated with an antibody against the HAtag and analysed ... [15,19] and its regulation. SNX9 and SNX18 show more than40% identity in the amino acid sequence of their SH3domains, which share a preference for binding toclass I ligand motifs and dynamin-2 ... (grant number 31003A-108283) and the Faculty of Biology and Medicine of the Uni-versity of Lausanne (grant number 22172). F.L. wassupported in part by grants from the Swiss NationalFunds (grant...

báo cáo khoa học: "Nanoscaled carborane ruthenium(II)-arene complex inducing lung cancer cells apoptosis" ppsx

... potential candidate for lung cancer che-motherapy. Those results provide the evidence thatremarkable enhancement of apoptosis can be induced and tumor growth can be inhibited by anticancer effectof ... the complex may be used asnanodrug, for cancer targeting, and intracellular labeling.Although ruthenium (II)-arene complex is used as an anti SMMC-7721 and HELF cancer drug [ 6], our group,along ... following antibodies were used: anti-cleavedCaspase-8, anti-cleaved Caspase-9, anti-cleaved Caspase-3, and anti-PARP antibody. GAPDH was served as a loading control.Zhang et al. Journal of Nanobiotechnology...

Tài liệu Báo cáo khoa học: Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity docx

... and monocytesto the site of injury, and to enhance phagocytosis and the maturation of dendritic cells. All of these effectswill augment the uptake, processing and presentationof antigen, and ... the antimicrobial activity and inmuno-modulatory functions of antimicrobial peptides, theskin plays a major and active role in the onset and development of an immune response to injury and microbial ... 91–110.33 Frohm M, Gunne H, Bergman AC, Agerberth B,Bergman T, Boman A, Liden S, Jornvall H & BomanHG (1996) Biochemical and antibacterial analysis ofhuman wound and blister ﬂuid. Eur J Biochem...

Tài liệu Báo cáo khoa học: Destabilization of psychrotrophic RNase HI in a localized fashion as revealed by mutational and X-ray crystallographic analyses pdf

... residues 29, T34 and E131 are shown. The hydrogen bonds betweenN29 and Oc and T34 and Oc, and between N29 and Nd and E131 and Oe2, in the wild-type protein are shown as green broken lines, and the ion ... hydrogen bondsbetween D39 and Od1 and Q149 and Ne, and between D39 and Od2 and Q149 and Ne, in the wild-type protein are shown as green brokenlines together with the distances. For the structure ... Lys90 and Lys89 and ⁄ or between Lys90 and Arg97 are eliminated.The Arg97 ﬁ Gly mutation stabilizes the wild-type and 4·-RNase HI proteins by 5.4 and 3.4 °C, respec-tively, in Tm, and 3.5 and...

Tài liệu Báo cáo khoa học: Analysis of the molecular dynamics of medaka nuage proteins by ﬂuorescence correlation spectroscopy and ﬂuorescence recovery after photobleaching doc

... a nanos–RFP or tudor–GFPfusion gene was cotransfected with the olvas–GFP orolvas–RFP fusion gene, and diffusion analysis byFCS and FRAP was performed. As shown inFig. 4A, Olvas–GFP and Nanos–RFP ... ﬂuorescent protein and Olvas, Nanos orTudor fusion proteins [enhanced GFP (EGFP)–Olvas,mRFP–Olvas, EGFP–Nanos, mRFP–Nanos, EGFP–Tudor, and mRFP–Tudor chimera], and was transcribedfrom the ... medaka embryos and the gran-ules in HeLa cells. FRAP revealed that it moved withtwo diffusion components in both PGCs and HeLacells: 0.15 and 0.01 lm2Æs)1in PGCs, and 0.9 and 0.03 lm2Æs)1in...

Tài liệu Báo cáo khoa học: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5¢-phosphate synthases of fungi and archaea docx

... substrate of the reductase and can be progres-sively regenerated from the a anomer by spontaneousanomerisation.Kinetic analysis of the recombinant proteinsfrom C. glabrata and A. aeolicus was performed ... glabrata and 3.5S for A. aeolicus(Fig. 3A and Fig. S2A). Sedimentation equilibriumanalysis indicated relative masses of 57.8 kDa(C. glabrata) and 50.6 kDa (A. aeolicus) (Fig. 3B and Fig. S2B). ... tonnes per year) ofthe vitamin for use in human and animal nutrition and as a non-toxic food colorant [8]. However, fermenta-tion processes using yeasts and eubacteria have nowcompletely replaced...

Xem thêm