báo cáo khoa học: "Effects of plasma concentrations of 5-fluorouracil on long-term survival after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma" doc

... Takemoto Y, Nakamura T, Kataoka K, Sakaeda T: Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/ cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous ... overall survival in Japanese patients with esophageal squamous cell carcinoma. Line: patients with plasma concentrations of 5-FU of 0.114...

Ngày tải lên: 10/08/2014, 10:21

... func- tion in elderly patients, which is in line with previous find ings demonstrating an association between increased s-TATI concentrations and an impaired renal function [18]. Notably, s-creatinine ... association between t-TATI and clinical stage, neither in the full cohort nor in rectal cancer patients [1]. The lack of an association between t-TATI and s-TATI with s-CE...

Ngày tải lên: 09/08/2014, 09:21

... the enzymes are product sensitive. Data about protein abundance in signal transduction cascades are now in hand, showing that members of the cascades are pre- sent in concentrations of the same order of ... example, the individual concentrations of Table 1. Concentrations of members of the MAPK cascade (MAPKKK, MAPKK, MAPK) in different organisms and cell types as...

Ngày tải lên: 19/02/2014, 07:20

... terminal nitrogen of the arginine side chain. Both Type I and Type II PRMTs catalyze monomethylation as a reaction intermediate [4]. Post-translational modifications within T -cell- recep- tor signaling ... specificity of compound 4 by evaluating its effects on a panel of catalytically active recombinant Type I PRMTs using AMI-1 for compari- son (Fig. 2A, B). Using in vitro methyl...

Ngày tải lên: 06/03/2014, 11:20

... resulting from benzhydr- oxamic acid of concentration L, binding to a total protein concentration P, was determined, while allowing the remaining K d and maximum absorbance change at satura- tion ... comparison of the electronic absorption and RR spectra of the wild type and Thr171Ser either in the presence of the aromatic donor BHA or at alkaline pH. Addition of saturating amou...

Ngày tải lên: 07/03/2014, 21:20

... 97.4% Table 3: Parsing performance using the PARIS approach Data Sets SearchTerm Extraction Accuracy LocationTerm Extraction Accuracy Input ASR WCN Oracle Transcription ASR WCN Oracle Transcription 1-best ... parsing approach called PARIS (parsing using indexing and search). We start by presenting a model for parsing ASR 1-best and extend the ap- proach to consider ASR lattices. 4.1 Query P...

Ngày tải lên: 08/03/2014, 21:20

... The Authors Journal compilation ª 2010 FEBS 2133 Effects of thymoquinone on isolated and cellular proteasomes Valentina Cecarini, Luana Quassinti, Alessia Di Blasio, Laura Bonfili, Massimo Bramucci, Giulio ... forestomach carcinogenesis in mice by thymoquinone. Eur J Cancer Prev 8, 435–440. 9 Badary OA, Abd-Ellah MF, El-Mahdy MA, Salama SA & Hamada FM (2007) Anticlastogenic activity...

Ngày tải lên: 15/03/2014, 11:20

... leading to inhi- bition of the intrinsic coagulation pathway. Triafestin inhibits FXII and PK reciprocal activation and bradykinin generation To investigate inhibition of the kallikrein–kinin ... of the intrinsic coagulation pathway. We then examined the anticoagulation activity of triafestin-1 and triafes- tin-2 using human plasma pretreated with APTT reagent in the absence of...

Ngày tải lên: 16/03/2014, 05:20

... situated in the interface between the helicase and the protease domains, creating a well-defined binding cleft (Fig. 1A) [7]. Indeed, it appears that certain residues in the heli- case domain may ... zinc atom in the protease domain and a phos- phate group in the helicase domain are also visible. The interface region between the helicase and the protease domains is framed and show...

Ngày tải lên: 16/03/2014, 06:20

... / angles at position 157 are in a region of the Rama- chandran plot that is allowed only for glycine. Substi- tuting any amino acid at this position would result in a change in the conformation ... conformation of this loop. Changes in the conformation of the backbone at this point and changes in the orientation of other side chains, as a result of the introduction...

Ngày tải lên: 16/03/2014, 06:20