báo cáo khoa học: "Effects of plasma concentrations of 5-fluorouracil on long-term survival after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma" doc
... Takemoto Y, Nakamura T, Kataoka K, Sakaeda T:
Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/
cisplatin-based chemoradiotherapy in Japanese patients with
esophageal squamous ... overall survival in
Japanese patients with esophageal squamous cell carcinoma.
Line: patients with plasma concentrations of 5-FU of 0.114...
... func-
tion in elderly patients, which is in line with previous
find ings demonstrating an association between increased
s-TATI concentrations and an impaired renal function
[18]. Notably, s-creatinine ... association between t-TATI and clinical
stage, neither in the full cohort nor in rectal cancer
patients [1]. The lack of an association between t-TATI
and s-TATI with s-CE...
... the
enzymes are product sensitive. Data about protein
abundance in signal transduction cascades are now in
hand, showing that members of the cascades are pre-
sent in concentrations of the same order of ... example, the individual concentrations of
Table 1. Concentrations of members of the MAPK cascade
(MAPKKK, MAPKK, MAPK) in different organisms and cell types as...
... terminal nitrogen of the arginine
side chain. Both Type I and Type II PRMTs catalyze
monomethylation as a reaction intermediate [4].
Post-translational modifications within T -cell- recep-
tor signaling ... specificity of compound 4 by
evaluating its effects on a panel of catalytically active
recombinant Type I PRMTs using AMI-1 for compari-
son (Fig. 2A, B). Using in vitro methyl...
... resulting from benzhydr-
oxamic acid of concentration L, binding to a total protein
concentration P, was determined, while allowing the
remaining K
d
and maximum absorbance change at satura-
tion ... comparison of the electronic absorption
and RR spectra of the wild type and Thr171Ser either
in the presence of the aromatic donor BHA or at
alkaline pH. Addition of saturating amou...
... 97.4%
Table 3: Parsing performance using the PARIS approach
Data Sets SearchTerm Extraction Accuracy LocationTerm Extraction Accuracy
Input ASR WCN Oracle Transcription ASR WCN Oracle Transcription
1-best ... parsing approach called PARIS (parsing
using indexing and search). We start by presenting
a model for parsing ASR 1-best and extend the ap-
proach to consider ASR lattices.
4.1 Query P...
... leading to inhi-
bition of the intrinsic coagulation pathway.
Triafestin inhibits FXII and PK reciprocal
activation and bradykinin generation
To investigate inhibition of the kallikrein–kinin ... of
the intrinsic coagulation pathway. We then examined
the anticoagulation activity of triafestin-1 and triafes-
tin-2 using human plasma pretreated with APTT
reagent in the absence of...
... situated in
the interface between the helicase and the protease
domains, creating a well-defined binding cleft (Fig. 1A)
[7]. Indeed, it appears that certain residues in the heli-
case domain may ... zinc
atom in the protease domain and a phos-
phate group in the helicase domain are also
visible. The interface region between the
helicase and the protease domains is
framed and show...
... /
angles at position 157 are in a region of the Rama-
chandran plot that is allowed only for glycine. Substi-
tuting any amino acid at this position would result in
a change in the conformation ... conformation of this loop. Changes in
the conformation of the backbone at this point and
changes in the orientation of other side chains, as a
result of the introduction...