báo cáo khoa học: " Response to dexamethasone is glucose-sensitive in multiple myeloma cell lines" pps

... DEX and this action seems mainly involving pathways regula ting ROS in MM cells. Whether this finding will help in reducing DEX toxicity or improving its efficacy particularly in combination with ... eukemic cells and primary thymocytes [13]. WeshowthatTXNIP-ROS-TRXaxisisfunctionalin response to glucose in 3 out of 4 MM cell lines tested and TXNIP RNA level is responsive to...

Ngày tải lên: 10/08/2014, 10:21

... instructions. HOKs This cell line was obtained from Sciencell (San Diego, CA, USA) and was delivered by PromoCell GmbH. The cell line is of fetal origin. Cell culturing was carried out according to the manufacturer’s ... VE-cadherin has been shown to induce breast cancer cell apoptosis and growth inhibition [19]. In this study, we investigated whether soluble trun- cated P-cad...

Ngày tải lên: 30/03/2014, 04:20

... achieved by incubation for 5 min with 3- 3’ diaminobenzidine (DAB) leading to cytoplasmic brown precipitates. Cells were counterstained with hematoxylin. For flow cytometry analysis, cells were ... to FITC, diluted to 1/100 in incubation buffer. Cells were washed and resuspended in 1 ml of PBS for flow cytometry analysis. Measurement of ganciclovir-induced cytotoxicity in synchron...

Ngày tải lên: 10/08/2014, 10:21

... recurrent disease. These results indicate that imatinib sensitivity can be maintained in a patient with previous exposure to adjuvant imatinib therapy. Introduction Gastrointestinal stromal tumors (GIST) ... assistance was provided by Novartis Pharmaceuticals. I thank Jinling Wu, MD, PhD, for her medical editorial assistance with this manuscript. Competing interests YKK is a consultant...

Ngày tải lên: 10/08/2014, 23:20

... lyso- somal machinery [3,4]. Autophagic signaling in response to nutrients is mainly relayed through the serine-threonine kinase mammalian target of rapa- mycin (mTOR). Indeed, mTOR is activated ... autophagocytosis, cells have the ability to internalize and degrade extracellular particles via het- erophagocytosis (hereafter referred to as phagocytosis) [5,6]. Lower organisms us...

Ngày tải lên: 23/03/2014, 04:21

... Bilingual case prediction task: simulating case prediction in MT Incorporating a case prediction model into MT requires taking additional factors into consideration, compared to the monolingual ... We employ this decomposition mainly for effi- ciency in training: that is, the decomposition allows us to train the classification models on a subset of training examples consisting o...

Ngày tải lên: 23/03/2014, 18:20

... expected to dete~ (these may he due to spelling or typing or grammatical mistakes by the typist, but this is irrelevant here: the classification is according to the type of processing required ... used to decide when to flag putative errors will be chosen by the user, so that users can optimise precision or recall. It is not clear how this kind of user- customisation cou...

Ngày tải lên: 24/03/2014, 05:21

... to induce GCL. The increase in GSH after t-BHQ in this latter cell line may derive from a combination of cytoprotective effects of this treatment [36], however, the increase in highG93A-tTA cells ... the late time point when the total GSH level was higher in highWT-tTA cells than in highG93A-tTA cells. These mechanisms need to be investigated further. The increase in GSH was...

Ngày tải lên: 29/03/2014, 23:20

... sim- ply stores all training examples in memory, with- out abstracting away from individual instances in the learning process. In contrast, our other classifier is a "greedy" learning algorithm, ... ac- cording to their importance in the classification task. According to the results of iterative deepen- ing, this importance is defined by the Chi-squared statistic mea...

Ngày tải lên: 31/03/2014, 20:20

... class="bi x0 y0 w0 h 0" alt ="" en dessous de celle de la lignée LR ou au-dessus de HR laissent à penser que plus d’un gène majeur se trouve impliqué dans le déterminisme ... an independent control of the responsiveness of this trait to the environment. So far, the traits and organisms involved in these studies have been growth rate in...

Ngày tải lên: 09/08/2014, 22:23