báo cáo khoa học: " Downregulation of CDKN2A and suppression of cyclin D1 gene expressions in malignant gliomas" doc

... phosphorylation of pRb and expression of cyclin D1 in T98G, U87-MG and SW1783 glioma cell lines transfected with CDKN2A (A). However, knockdown of CDKN2A increased the phosphorylation of pRb and cyclin D1 in ... frequently inactivated in GBM. The CDKN2A acts as a cyclin- dependent kinase inbibitor, inbibiti ng the binding of the CDK4 protein to cylclin D...

Ngày tải lên: 10/08/2014, 10:21

... phytoalexins brassicanal A, erucalexin, rutalex- in, brassilexin, camalexin (chemical structures in Fig. S2) and cyclobrassinin [7]. Interestingly, only cyclobrassinin (Fig. 8A) exhibited an inhibitory ... phyto- alexin that displayed an inhibitory effect was further examined in order to determine the type of inhibition and the K i using brassinin (0.10–0.40 mm) as a sub- strate i...

Ngày tải lên: 18/02/2014, 14:20

... strategy to increase the number of transcripts instead of having a strong transcription promoter. The fact that several genes can be the source of several isoforms in the branchial plume could increase ... posi- tions 94, 96 and 119 in CAII from Homo sapiens) which are directly involved in binding the zinc cofac- tor, are conserved in the two R. pachyptila sequences (positions...

Ngày tải lên: 18/02/2014, 16:20

... the A C B Fig. 2. Effect of the binding of ATP ⁄ Mg 2+ to 2-Cys Prx on the fluo- rescence emission of extrinsic and intrinsic chromophores. (A) Sen- sitivity of the extrinsic probe ANS. Binding of ANS to 2-Cys ... information about the polarity of local environments surrounding either extrinsic probes that bind to proteins or intrinsic fluorophores buried in the protein interior...

Ngày tải lên: 18/02/2014, 17:20

... FAD-binding protein or flavoprotein (Fp, 68 kDa, 622 amino acids), the iron–sulfur protein (Ip, 29 kDa, 252 amino acids), and two membrane- anchor proteins (CybL, 15 kDa, 140 amino acids, and CybS, ... 11 kDa, 103 amino acids) with a total of six transmembrane helices. Here we provide a detailed report of the preparation, gene sequencing, N-terminal sequencing and crystallization...

Ngày tải lên: 19/02/2014, 02:20

... essential [46], disruption of P6 in Cr.LSU obliterated self-splicing, and point mutations in P4 strongly decreased splicing in vitro and in vivo, indicating that the P5–P4–P6 domain is important for ... dependence of this effect indicates that the nucleotide is acting via the G binding site in P7. An obvious explanation for this result is that binding of GMP prevents an in...

Ngày tải lên: 19/02/2014, 07:20

... well-characterized peptides (some of them including a-conotoxin SI) and proteins. One of the original comprehensive studies of disulfide bond linkage relevant to conotoxins involved analysis of differ- entially ... place of the single hydroxyproline residue [5]. Amidation of the C-terminus is a feature of most conotoxins and so far occurs in the majority of the a-conotoxi...

Ngày tải lên: 19/02/2014, 12:20

... between stem frequency in Covo during year t and frequency change in MZEE between t and year u = t + i Initial frequency and dissemination in MZEE In studying the fate of all words in two En- glish ... detection of English inclusions in mixed-lingual data with an application to parsing. Ph.D. thesis, Institute for Communicat- ing and Collaborative Systems, School of...

Ngày tải lên: 19/02/2014, 19:20

... class="bi x0 y1 w4 h 4" alt =""

Ngày tải lên: 20/02/2014, 18:20

... 2002. Extract- ing Relational Facts for Indexing and Retrieval of Crime-Scene Photographhs. In A. Macintosh, R. El- lis, and F. Coenen, editors, Applications and Inno- vations in Intelligent Systems ... ontology. 1 Indexing and Retrieval of Photographs The normal practice in human indexing or cata- loguing of photographs is to use a text-based rep- resentation of the pi...

Ngày tải lên: 22/02/2014, 02:20