báo cáo khoa học: " Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma" potx

... fluvasta- tin and simvastatin decrease the activation of ERK1/2 Akt [4]. These findings are in agreement with the results of the present study and indicate that statins induce apoptosis via suppression ... whether the inhibi- tion of ERK1/2 and Akt activation in C6 glioma cells was due to the inhibitory action of statins on FPP or GGPP biosynthes...

Ngày tải lên: 10/08/2014, 10:21

... Animal Institute of Peking Union Medical College and maintained under standard conditions according to the guidelines of the Institutional Animal Care and Use Committee of Peking University. The ... cell growth by inducing apoptosis [21] and inhibits the migra- tion, invasion a nd adhesion capacity by down-regulating the expression of CD44 v6 protein [22]. Howeve...

Ngày tải lên: 10/08/2014, 10:21

... (min) pAkt /Akt (R.U.) AKT pAKT 03060 Time (min) BBG 100 nM AB CD EF Fig. 8. P2X7 receptor inhibition increases Akt and GSK3 phosphorylation in N2a cells. (A, B) Western blots of p S473 Akt and ... resulting in Akt activation and GSK3 inhibition. It should be noted that increased Akt activ- ity can also induce the inhibition of GSK3, which has been proposed t...

Ngày tải lên: 07/03/2014, 02:20

... group of CDK inhibitors comprising two families of proteins: inhibitor of kinase 4 ⁄ alternative reading frame and CDK inhibitor protein ⁄ kinase inhibitor protein. The inhibitor of kinase 4 ⁄ alternative ... kinase inhibitor protein family includes p21 WAF1 , p27 Kip1 , and p57 Kip2 . They halt the cell cycle in the G 1 phase by binding to, and inactivating, cyclin–CD...

Ngày tải lên: 15/03/2014, 10:20

... Cd 2+ on the kinetics of the CoQ-oxidizing module (A) and CoQ-reducing module (B). Effect of Cu 2+ on the kinetics of the CoQ-oxidizing module (C) and CoQ-reducing module (D). The kinetics of the CoQ-oxidizing ... CoQ-oxidizing module were obtained by titrating with a specific inhibitor of the CoQ-reducing module, malonate (0–3.125 l M). The kinetics of the...

Ngày tải lên: 16/03/2014, 02:20

... All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein. Journal of Experimental ... and imatinib The result of isobologram was showed in Figure 5B. All data points in the combination fell within the envelope of additivity, the area surro...

Ngày tải lên: 10/08/2014, 10:20

... of the input and the eluate of the chromatography were resolved by Tricine ⁄ SDS ⁄ PAGE and then analyzed by Coo- massie Brilliant Blue staining (left) and western blotting (right). Lane 1: input ... suggesting that this peptide may also affect the development of the wing disks at the prepu- pal stages. It is interesting to note that bombyxin-II also stimulated th...

Ngày tải lên: 18/02/2014, 13:20

... that the most characteristic signatures in the sequences are present in both proteins, tyrosinases and catechol oxidases; these include the six histidine resi- dues involved in the binding of a ... browning of fruits and vegetables, and morphogenesis and fruiting body formation in fungi. All of these processes involve melanin formation. In the bacterial kingd...

Ngày tải lên: 19/02/2014, 07:20

... especially with the series of Mes- sage Understanding Conferences of the nineties, has focused on tasks such as creating and updating databases of corporate join ventures or terrorist and guerrilla ... on the pro- blem of identifying and organizing into a useful database structure the different linguistic consti- tuents of the candidate predications, a phase simi-...

Ngày tải lên: 20/02/2014, 15:20

... monitored by the reduction of cytochrome c in the presence of NADH at 550 nm [1]. Protein determination Protein content was determined by the Bradford test [20], using bovine serum albumin as standard. PHI ... explain the regulatory effect. In fact, on addition of PHI, the fluorescence of PHR-bound flavin increases. This finding points to a PHI-induced conformational ch...

Ngày tải lên: 21/02/2014, 00:20