báo cáo khoa học: " Continuous and low-energy 125I seed irradiation changes DNA methyltransferases expression patterns and inhibits pancreatic cancer tumor growth" pps

... of continuous and low-energy 125 I irradiation on apoptosis, expression of DNA methyltransferases (DNMTs) and cell growth in pancreatic cancers. Materials and methods: For in vitro 125 I seed irradiation, ... seed irradiation affects pancreatic cancer. 125 I seed implantation effec- tively inhibited tumor growth and reduced tumor volume, especially at 4...

Ngày tải lên: 10/08/2014, 10:21

... comparative, JJS: adjective and superla- tive, RBR: adverb and comparative, and RBS: adverb and superlative 153 Our final goal is to find an effective method to extract S1 and S2, but single-keyword ... perfor- mance of MEM (McCallum and Nigam (1998)). 3 Extracting Comparative-sentence Candidates In this section, we define comparative keywords and extract comparative-sen...

Ngày tải lên: 20/02/2014, 09:20

... RV, GA, J-CB and FZ participated in designing the study, collecting the samples and writing the manuscript. FJ, SM, VL and RB designed and conoducted the pharmacokinetic analysis, and helped to ... ceftazidime, followed by a 3 g/day continuous infusion for 72 hours. Serum samples were collected at 0, 3, 15 and 30 minutes and at 1, 2, 4, 6, 8, 12, 24, 36, 48 and 72 hours; dia...

Ngày tải lên: 12/08/2014, 23:21

... to be tested, and should be a major focus of future work. Authors’ response Eric B Milbrandt, Babak Sarani and Louis H Alarcon We would like to thank Dr Landrigan, Dr Lockley, and Dr Czeisler ... medical education and professionalism Christopher P Landrigan, Steven W Lockley and Charles A Czeisler Division of Sleep Medicine, Boston, Massachusetts, USA Corresponding author: Christoph...

Ngày tải lên: 25/10/2012, 10:45

... of ADP and Mg 2+ and followed by nondenaturing PAGE, the bands of the enzyme and the reactivase were markedly reduced in density, and two bands of the enzymeÆreactivase complexes (upper and lower) ... c, e, and g). To determine their subunit compositions, bands i–vi were excised and subjected to SDS⁄ PAGE on 6% and 14% gels (Fig. 5B,C), followed by densito- metric analyses. Bo...

Ngày tải lên: 15/02/2014, 01:20

... bladder and kidney, and in gliomas. EGFR expression and cancer prognosis have been investigated in many human cancers. Although there some discrepancies have been reported, patients with tumors ... phosphatidylinositol 3-kinase, and thus is a preferred dimerization partner. EGFR overexpression and cancer EGFR is expressed in a variety of human tumors, including those in the lu...

Ngày tải lên: 16/02/2014, 09:20

... structure. Expression patterns of AP-2 molecules and functional implications The expression and function of AP-2 isoforms have been systematically analyzed during murine embryo- genesis and in studies ... in the face and limbs. In a follow-up study, they found that this conserved cis-acting sequence serves to maintain a level of AP-2a expression that limits the size of the han...

Ngày tải lên: 16/02/2014, 09:20

... leukemia [3], lung cancer [4], colorectal cancer [5,6], breast cancer [7], papillary thyroid cancer [8] and hepatocellular carcinoma [9]. Gastric cancer is the second most common cause of cancer deaths ... populations [21]. In gastric cancer, IL6 contains polymorphisms [22]. The expression of IL6 is involved in gastric cancer invasion and lymph node and ⁄ or hepatic met...

Ngày tải lên: 18/02/2014, 04:20

... with in vitro cytosol and cell-free mitochondria, our data suggest a direct interaction between ETA and cyto- solic EF-2 on the one hand, and the mitochondrial membrane on the other hand. However, the ... endosomal cathepsins B and D physiologically translocate from the endosomal lumen to the cytoplasm and interact with cytosolic targets (EF-2 and mitochondria). Low production an...

Ngày tải lên: 18/02/2014, 04:20

... acid and a base on each side of the hydrolyzed bond [16]. E96 and H137 in a-sarcin and E58 and H92 in RNase T1 act as the base and acid groups, respectively. Com- paring the 3D structures, E66 and ... N56–D58) and seven b-strands (b 1 , I3– C6; b 2 , F17–D20; b 3 , H42–Y44; b 4 , L64–P68; b 5 , R95– A99; b 6 , G109–H113; b 7 : F126–K128). The b-strands form an N-terminal hairpin...

Ngày tải lên: 18/02/2014, 08:20