báo cáo khoa học: "Anticancer activity of the iron facilitat

báo cáo khoa học: "Anticancer activity of the iron facilitator LS081" pps

... 1.22 ± 0.48 μM with a range of EC 50 of 0.5-2 μM for the remain der of the iron facilitators. Within the range of concentrations used over the length of the screening neither cell number nor cell ... transport activity in an in vitro system; however, a clue to the mode of action of the facilitators comes from our observation that LS081 increased iron uptake w...

Ngày tải lên : 10/08/2014, 10:21

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Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"

... suppressor activity. The PR domain of RIZ1 possessed anticancer activity from the transfec- tion studies. This finding leaves us an important question on the roles the other structural components of ... HuH7 cells. Thus, the above observation suggested that the PR domain alone pos- sesses anticancer activity. However, it is still unclear whether the anticancer activ...

Ngày tải lên : 25/10/2012, 11:15

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Báo cáo khoa học: "Clinical relevance of the PaO2/FiO2 ratio" pps

... see the results of an assessment by Karbing and coworkers of the behavior of Pa O 2 /(FiO 2 × MAP) in their mechanically ventilated patients occurring in response to changes in Fi O 2 . Nevertheless, ... breathing patients, they showed that the clinical utility of Pa O 2 /FiO 2 ratio is doubtful unless the FiO 2 level at which the Pa O 2 /FiO 2 ratio is measured is specified...

Ngày tải lên : 13/08/2014, 10:20

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Tài liệu Báo cáo khoa học: Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity docx

... doi:10.1046/j.1432-1033.2003.03657.x However, the 9-mer peptide B, CGGWHRLRC, corres- ponding to the sequence of the MGD1 loop 3 occurring between the two b-strands, had an MIC of 28 l M (i.e. about 2.5% of the activity of the synthetic ... detectable activity. The bacteriostatic activity of the sequence 25–33 was strictly dependent on the bridging of Cys25...

Ngày tải lên : 20/02/2014, 11:20

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Tài liệu Báo cáo khoa học: High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine pptx

... polarization of the C–O bond by the dipoles of the oxyanion hole in conjunction with the inﬂuence of a close nucleophile like the Oc of the catalytic serine. The same type of adduct was observed previously ... transfer to the leaving group of the substrate occurs. Proton transfer The requirement of an acceptor for the Oc proton from the catalytic serine i...

Ngày tải lên : 20/02/2014, 23:20

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Báo cáo khoa học: Antimicrobial activity of histones from hemocytes of the Paciﬁc white shrimp ppt

... present the results of a proteomic investigation of hemocyte antimicrobial peptides of the P aciﬁc white shrimp, L. vannamei, and the r ole of histones as potentially important components of their ... to separate the hemocytes from the plasma. After removal of the plasma from the cell p ellets, 600 lLof MAS was added to the eppendorf tubes, which were then vortexed...

Ngày tải lên : 07/03/2014, 16:20

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Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx

... mammalian cells [9], the SCC reaction is the rate-determining step in progesterone synthesis in yeast. The yeast SCC system offers the possibility of increasing or decreasing the availability of the endogenous ... concentrations of the steroid (Fig. 5). Therefore, these results reveal two levels of complexity of the CYP11A1 reaction in yeast. On one hand, the conte...

Ngày tải lên : 08/03/2014, 08:20

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Báo cáo khoa học: Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis Functional analysis of the promoter identiﬁes a calcium sensitive region required for basal activity doc

... analysis of the 5 ¢ end of the xMGP promoter reveale d a minimal activating ele- ment in the s equence from )70 to )36 bp. Synthetic reporter constructs containing three c opies of the d eﬁned ... receptors (including the vitamin D, retinoic acid and thyroid hormone receptors) did not modulate the activity of the )949LUC reporter signiﬁcantly, either in presence or abs...

Ngày tải lên : 08/03/2014, 10:20

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Báo cáo khoa học: Catalytic mechanism of the primary human prostaglandin F2asynthase, aldo-keto reductase 1B1 – prostaglandin D2 synthase activity in the absence of NADP(H) pptx

... although the PGDS activity of AKR1B3 was 24% of the PGFS activity (Fig. S1A). The optimum pH values were found to be pH 5.0 for PGFS activity and pH 8.5 for PGDS activity of AKR1B3. The pK b value of ... catalyzed the reduction of the 9,11-endoperoxide group of PGH 2 to produce PGF 2a in the presence of NADPH, which was deﬁned as the PGFS activity, and...

Ngày tải lên : 14/03/2014, 23:20

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Báo cáo khoa học: Lid L11 of the glutamine amidotransferase domain of CTP synthase mediates allosteric GTP activation of glutaminase activity docx

... analysis of the structure of the T. thermophilus enzyme [15], it is suggested that the binding of ATP and UTP to the enzyme brings together the GATase and the synthase domains and enables the formation ... BioCentrum-DTU, The Technical University of Denmark, Lyngby, Denmark CTP synthase (EC 6.3.4.2) catalyses the synthesis of CTP by amination of the 4-position...

Ngày tải lên : 23/03/2014, 13:20

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