báo cáo khoa học: " Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells" ppsx

... rapamycin will result in some beneficial modulation of the cancer kill- ing properties of docetaxel in lung cancer cells [20,21]. To the best of our kno wledge, the effect of including rapamycin in ... 30:28 http://www.jeccr.com/content/30/1/28 Page 6 of 8 RESEARC H Open Access Rapamycin potentiates cytotoxicity by docetaxel possibly through downregu...

Ngày tải lên: 10/08/2014, 10:21

... our experimental setup. Instead of dividing datasets during 10-fold cross-validation into training and test subsets with the ratio of 9:1 we randomly split the data into training, validation and ... each dataset into 10 subsets where each subset was a test set and the corre- sponding 9 remaining sets were merged to a train- ing set. We kept the labels of the training set to determine mo...

Ngày tải lên: 20/02/2014, 04:20

... gastrointestinal manifestations, and overt clinical heart failure. The pathological involvement of the heart in the chronic phase of Chagas disease is character- ized by the presence of inflammatory ... explained by the contrasting changes in central and peripheral conduits. In our study, the absence of modifications in carotid pulse-wave veloc- ity in Chagas' disea...

Ngày tải lên: 11/08/2014, 08:20

... 10,517 sentences of varying lengths, it pulled out 500 as possibly containing a repair and missed 97 sentences actually containing a repair. Of the 500 that it proposed as containing a repair, ... edits, and also including the original string un- changed. Each of these strings was analyzed by the parser. When the original sequence did not 60 parse, but one of edits result...

Ngày tải lên: 31/03/2014, 06:20

... by immunohistochemical staining using monoclonal antibody against human podoplanin (clone D2-40) and evaluated by counting the number of immunostained lymphatic vessels in 10 hot spot areas at ... researchers groups. In this study, we evaluated LMVD in the intratumoral compartment using podoplanin as the lymphatic marker. Vascular density was determined by direct counting of v...

Ngày tải lên: 09/08/2014, 03:22

... 1-year LC rate of more than 75% (Fig. 2) The significant influence of total dose on duration of survival in this cohort of patients with metastatic lung cancer was the main finding of this analysis ... another phase III trial assessing the efficacy of gadolinium motexafin [12]. Patien ts with BM from lung cancer presented with an increase of fine motor and visual motor...

Ngày tải lên: 09/08/2014, 08:22

... C-terminal motif in the APETALA3 gene lineage. BMC Evol Biol 2006, 6:30. 64. Yang Y, Jack T: Defining subdomains of the K domain important for protein-protein interactions of plant MADS proteins. ... 11:57 http://www.biomedcentral.com/1471-2229/11/57 Page 18 of 18 [14], any strategy aiming to increase the accuracy of QTL detecti on without increasing the popu lation size is of gre...

Ngày tải lên: 11/08/2014, 11:21

... analysis using Ingenuity [30] revealed several interactions that involve the 83 WL genes, including a calmodulin kinase gene network (Figure S3A in Additional data file 3), supporting the wet- lab ... Atherton P, Selby A, Rennie MJ: Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle. Am J Physiol Endocri...

Ngày tải lên: 11/08/2014, 12:20

Ngày tải lên: 12/08/2014, 23:21

... selectively Figure 1 Interaction of antithrombin with endothelium. The affinity of antithrombin (AT) to thrombin and its enzymatic inhibition is increased by binding of AT with the heparan-binding site to ... kinases [38], src tyrosine kinases [69] and sphingosine kinase [37]. Antithrombin enhances Tyr416 and inhibits Tyr527 phos- phorylation of src tyrosine kinases; in combinatio...

Ngày tải lên: 12/08/2014, 23:21