báo cáo khoa học: " Upregulation of microRNA-451 increases c

báo cáo khoa học: " Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549)" pot

... article as: Bian et al.: Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549). Journal of Experimental & Clinical Cancer Research 2011 30:20. Submit ... affect the sensitivity of non-small cell lung cancer (NSCLC) cells to cisplatin (DDP) remains unclear. The aim of this study is to evalua...

Ngày tải lên : 10/08/2014, 10:21

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Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx

... Co-expression of p25a and the dopamine transporter in HEK-293-MSR cells sensitized them to the toxicity of extracellular dopamine. Neuronal expression of p25a thus holds the potential to sensitize the cells ... visualization of subcellular co-localization compared to the epithelial morphology of HEK-293- MSR cells. DAT was found to localize in the cellular processes, together with g...

Ngày tải lên : 14/02/2014, 21:20

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Tài liệu Báo cáo khoa học: Upregulation of the a-secretase ADAM10 – risk or reason for hope? docx

... turnover of TACE in Jurkat cells [49] and diminished the amount of mature TACE in HEK293 as well as in SH-SY5Y cells [45]. Interest- ingly, these cell lines did not show altered amounts of ADAM10, ... progres- sion of certain cancer types such as prostate or breast cancer [78–80]. Furthermore, it plays a role in metasta- sis of human colon cancer cells [81]. Therefore, the i...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis doc

... higher dose of 20 Gy induced signiﬁcant cell death in all three cell lines after 48 h ( 20–30%), and was capable of potentiating TRAIL-induced cell death in the TRAIL-sensitive cell line U87. ... the TRAIL-resistant cell lines (Fig. 1B). It is of note that this lack of apoptosis reactivation was inde- pendent of the p53 status of these cells, as U343 cells, but not U3...

Ngày tải lên : 18/02/2014, 17:20

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Báo cáo khoa học: Upregulation of endothelial adhesion molecules by lysophosphatidylcholine pptx

... no significant cell death was observed even at a high con- centration (25 lm) of LPC (Fig. 1D). Contribution of NF-jB to LPC-induced activation of AMs To define the molecular mechanism of LPC-induced upregulation ... LPC-induced upregulation of AMs, the influence of LPC on NF-jB activation was investigated in YPEN-1 cells. This is because the predominant regulatory role of NF...

Ngày tải lên : 30/03/2014, 09:20

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Báo cáo khoa học: " Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit"

... remit of the local ethics committee. Prior to introduction of CPOE, local standards of prescribing existed specifying the tenets of good practice, including the avoid- ance of the use of abbreviations. An ... strong linear trend of a declining proportion of MEs over time (p < 0.001). The types of error from the two systems are listed in Table 1. CPOE appeared to be associ...

Ngày tải lên : 25/10/2012, 10:39

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Tài liệu Báo cáo khoa học: Enzymatic and electron paramagnetic resonance studies of anabolic pyruvate synthesis by pyruvate: ferredoxin oxidoreductase from Hydrogenobacter thermophilus doc

... A 340 as a result of NADH oxidation was measured. One unit of enzyme activity was deﬁned as the reduction of 1 lmolÆmin )1 of NADH (corresponding to the carboxylation of 1 lmolÆmin )1 of acetyl-CoA). Quantiﬁcation ... Ishii 1 and Yasuo Igarashi 1 1 Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan 2 Department of...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx

... Apoptotic cells were identiﬁed by the condensation and fragmentation of their nuclei. The percentage of apoptotic cells was calculated as the number of apoptotic cells divided by the total number of cells ... stage, Q2 cells were cells at the late apoptosis stage, and Q1 cells were necrotic cells. The percentage of apoptotic cells was also calculated (B). The results are representat...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

... effects of one of the substrates, i.e. pantoate [8,9]. One of the interesting features of the plant PSs is the presence of a conserved 24 residue insertion in the sequence [9]. This sequence of amino ... interpretations from being made. An important outcome of this study is the potential use of bipantoate molecules [40] as inhibitors of this enzyme, with the aim of develop...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx

... weight of TG mice was larger than that of WT mice (Fig. 2C); this was accompanied by upregulation of the expression of adipogenic genes in WAT (Fig. 3B), suggesting pronounced differentiation of adipocytes ... amounts of triglycerides during periods of energy excess and to mobilize these depots during periods of nutritional deprivation. The number of adipocytes is thought...

Ngày tải lên : 16/02/2014, 09:20

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