báo cáo khoa học: " Inhibition of telomerase activity by HDV ribozyme in cancers" ppsx

... homologues of HDV ribozym es, and sequence variation of the HDV ribozymes in clinical isolates is minimal. Then we imagine whether HDV ribozyme can be used to inhibit hepatocellular carcinoma. In the ... trafficking of human telomerase to telomeres. Mol Biol Cell 2006, 17(2):955-65. 25. Bailin LIU, Yi QU, Shuqiu LIU, Xuesong Ouyang: Inhibition of telomerase in tumo...

Ngày tải lên: 10/08/2014, 10:20

... doxorubicin, etoposide, cisplatin, or carboplatin at the beginning of antisense treatment and after erosion of telomeres. They found no effects of TA inhibition on chemosensitivity at the beginning of antisense ... the effects of telomerase inhibition on chemo- and radiosen- sitivity of neuroblastomas, since small molecules, which inhibit TA i.e. by stabilizing the G-quadr...

Ngày tải lên: 09/08/2014, 09:20

... substrate dependent mode of inhibition in this kinetic range. The resulting inhibition constants ranged from 29 to 106 nm revealing effective inhibition of both A domains with DHB-AMS and SAL-AMS ... behaviour of the 2,3-dihydroxybenzoate activating domain DhbE (bacillibactin syn- thesis) and compares it to that of YbtE (yersiniabactin synthesis) upon enzymatic inhibition us...

Ngày tải lên: 23/03/2014, 11:20

... et al., Inhibition of angiogenesis- and inflam- mation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP Journal of Nanobio- technology ... and anti- inflammation agents in a human colon cancer HCT116 cell line in vitro, and in induced angiogenesis in ovo. Results: The studies described in this repo...

Ngày tải lên: 11/08/2014, 00:22

... 2). For instance in the absence of a pre-binding step, the addition of Prunella extracts at 2 h resulted in 77% inhibition of infectivity. In contrast, if the virus was pre- bound, 53% of the ... infection of ED cells using the single round of infection assay described below. Viral infection and time -of- addition studies Inhibition of infectivity studies All extracts...

Ngày tải lên: 12/08/2014, 04:21

... determined that enhanced expression of HEXIM1 resulted in a modest inhibition (2-fold) of P-TEFb activity in vivo. Thus, HEXIM1-mediated inhibition of Tat activity is unlikely due to a global inhibition ... found that the C-terminal region is required for inhibition. Pre- vious findings indicated that the C-terminal region of HEXIM1 is involved in binding with cyclinT...

Ngày tải lên: 13/08/2014, 09:21

... variations in identity (for example ranging from 38–86% in Coprinopsis cine- rea [27]). This natural diversity within in a single organism can be used for protein engineering purpose. In Trametes ... lead- ing to functional hybrids occur at positions that mini- mize disruption of interactions [18]. In the chimera, recombination preserved the integrity of domain D1 and the very e...

Ngày tải lên: 18/02/2014, 06:20

... Treatment of Cancer QLQ-C30: a quality- of- life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993, 85:365-376. 21. Sprangers MA, Groenvold M, Arraras JI, Franklin ... following mantle-field irradiation. Comparison of follow-up by conventional x-ray and by computed tomography]. Radiologe 1988, 28:20-28. 17. Lind P: Clinical relevance of pu...

Ngày tải lên: 09/08/2014, 09:20

... level of PKA enzyme activity. Induction of C/EBPb 3 (CCAAT/enhancer-binding pro- tein b) by cAMP/PKA might be involved in cAMP/PKA- mediated inhibition of NF-jB activity. In our preliminary experiments, ... CBP/p300 are not involved in the PKA-mediated inhibition of NF-jB To examine if CREB, a well-known nuclear substrate of PKA, is involved in the PKA-mediated inh...

Ngày tải lên: 08/03/2014, 10:20

... or cofactor. In detail, the N-terminal module is the homocysteine (Hcy)-binding domain; the second domain binds 5-methyltetrahydrofolate, the third domain binds CH 3 -Cbl; and the fourth domain ... the interactions occurring at the binding site, and to develop a tool that could assist further optimization of inhibitors, a molecular model of the methyltetra- hydrofolate-binding domain o...

Ngày tải lên: 19/02/2014, 05:20