báo cáo khoa học: " Ultrasound-targeted microbubble destruction mediated herpes simplex virus-thymidine kinase gene treats hepatoma in mice" pps

... Qi L, Chunjing Z, Hailin T, Lin G, Mingli P, Shiyu P: Ultrasoun -mediated microbubble destruction enhances VEGF gene delivery to the infarcted myocardium in rats. Clin Imaging 2004, 28:395-398. 13. ... electrogene transfer. J Gene Med 2003, 5(3):219-31. 26. Gentry BG, Boucher PD, Shewach DS: Hydroxyurea induces bystander cytotoxicity in cocultures of herpes simplex virus thym...

Ngày tải lên: 10/08/2014, 10:20

... with monensin [5]. In addition, both drugs comparably inhibited generation of the CT-A1 peptide. In rat liver, chloroquine accumulates in hepatic endosomes, leading to an increase in the lag ... after the in vivo administration of native CT, CT-B or diphtheria toxin (60 lg per 100 g body weight), and incubated in 0.15 M KCl containing 5 mM MgCl 2 ,5lM acridine orange and, when ind...

Ngày tải lên: 19/02/2014, 02:20

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Ngày tải lên: 07/08/2014, 18:21

... rate of inbreeding when there is selection within families, but delays inbreeding for three or so generations in populations of this size and minimises the variation in inbreeding level within the ... remaining two males formed the C line. The same procedure was followed subsequently until generation 20, with four males recorded every generation in each family in the selected lines an...

Ngày tải lên: 09/08/2014, 18:21

... and arrows indicate exons, and lines indicate introns. Green open or filled boxes indicate exons skipped or retained in certain ESTs. The top black scale indicates coordinates for the gene locus ... alternatively spliced. In general, the fraction of alternatively spliced genes keeps increasing with increas- ing transcript coverage, eventually reaching 66% in Os and 46% in At for g...

Ngày tải lên: 12/08/2014, 05:20

... Since differences in expression of proteins involved in the cytokine cascade are hypothesized as candidate genes, interactions between cytokine gene polymorphisms and these interventions would ... AG, et al.: Genetic variation in selenoprotein S influences inflammatory response. Nat Genet 2005, 37:1234-1241. 35. Sinha M, Larkin EK, Elston RC, Redline S: Self-reported race and genetic...

Ngày tải lên: 13/08/2014, 02:24

... tumor xenografts by the combination of ultrasound-targeted microbubble destruction and polyethylenimine to inhibit survivin gene expression and induce apoptosis. J Exp Clin Cancer Res 2010, 29:152. 26. ... agents (in a form of microbubble) have been used to deliver gene and drug in vitro and in vivo, providing a new and efficient therapeutic technique [22-25]. Ultrasound mic...

Ngày tải lên: 10/08/2014, 10:21

... 14-3-3 interaction [8]. Various kinases, including protein kina- se A (PKA), Akt, protein kinase C (PKC), and calcium and calmodulin-dependent kinase II (CaMK II), have been implicated in the generation ... (shaded area), with insulin (broken line) and with LY294002 and insulin (full line with unshaded area). (E) Effects of PI3K, insulin and fetal bovine serum on 14-3-3 binding to GPR15...

Ngày tải lên: 07/03/2014, 00:20

... DNA-binding domain (Gal4-BD) alone, indicating that the interactions with the different Moc proteins were specific. In a similar-two hybrid screen using Moc2 as bait, Moc2-interacting proteins ... Moc4-interacting proteins interacted with Moc2 in a yeast two-hybrid system. In addition, none of the Moc4-interacting proteins inter- acted with the Gal4-BD (Table 4). Interactions of Moc prot...

Ngày tải lên: 23/03/2014, 05:22

... ⁄ protein kinase B (PKB), protein kinase D (PKD), extracellular-signall regulated kinase 1 ⁄ 2 (ERK 1 ⁄ 2), mitogen-activated protein kinase (MAPK) p38] [12–17], caspases [18], lipid kinases ... mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3 -kinase ⁄ Akt, and mitogen-acti- vated protein kinase signaling pathways. Stem Cells 24, 2637–2648. 13...

Ngày tải lên: 30/03/2014, 02:20