báo cáo khoa học: "Antiproliferative factor decreases Akt phosphorylation and alters gene expression via CKAP4 in T24 bladder carcinoma cells" docx

... phosphorylated ERK, p38 and JNK (p-ERK, p -p38 and p -JNK) and total ERK, p38 and JNK (tERK, tp38 and tJNK). (B) The ratio of phosphorylated to total ERK (p44 ⁄ 42), p38 and JNK at each time point. The data ... 4345 Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of...

Ngày tải lên: 18/02/2014, 18:20

... inhibition of caspase-3 activity can block induction of apoptosis by Ab in primary neuronal cells and PC12 cells [14]. The neurotoxicity of Ab seems to depend on its ability to aggregate, and the ... we validated isoquinoline-1,3,4-trione and its derivatives as selective, irreversible, slow-binding, pan-caspase inhibitors. This compound and its derivatives pr...

Ngày tải lên: 07/03/2014, 11:20

... al. Human recombinant prolidase from CHO and E. coli FEBS Journal 273 (2006) 54665478 ê 2006 The Authors Journal compilation ê 2006 FEBS 5471 Human recombinant prolidase from eukaryotic and prokaryotic ... synthesis, purification and bio- chemical characterization of human recombinant proli- dase from eukaryotic and prokaryotic hosts and compare the e...

Ngày tải lên: 07/03/2014, 11:20

... Authors Journal compilation ê 2006 FEBS Interaction between catalytically inactive calpain and calpastatin Evidence for its occurrence in stimulated cells Monica Averna, Roberto Stifanese, Roberta ... clearly indi- cates that the ligand responsible for the changes in intracellular calpain conformation is its natural inhib- itor, calpastatin. The new conf...

Ngày tải lên: 07/03/2014, 12:20

... 271) Ó FEBS 2004 Effect of priming on activation and localization of phospholipase D-1 in human neutrophils Karen A. Cadwallader 1 , Mohib Uddin 1 , Alison M. Condliffe 1 , Andrew S. Cowburn 1 , ... distribution of PLD and the conse- quences of priming and activation were determined using immunoprecipitation and Western blot analysis of neutro- phil...

Ngày tải lên: 07/03/2014, 15:20

... FEBS The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B 1 and B 2 bradykinin receptors Alexander Faussner 1 , Alexandra Bauer 1 , Irina Kalatskaya 1 , ... agonist [20]. As the internalization is expressed in percentage of total binding, decreasing the binding affinity of the Role of...

Ngày tải lên: 07/03/2014, 16:20

... and hPDK4 gene expression FEBS Journal 272 (2005) 30043014 ê 2005 FEBS 3007 Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells Emily L. ... protein kinase kinase (MEK) inhibitor, U0126 [32,33]. Therefore, the role of the MAPK pathway in regulating PDK mRNA expression was investigated by incubati...

Ngày tải lên: 07/03/2014, 17:20

... therefore used this assay to analyze the interaction of Rabaptin-5d with Rab4 and Rab5. Similarly to Rabaptin-5, Rabaptin-5d was not able to bind Rab4 or Rab5 in the inactive, GDP-bound form as ... August 2004) doi:10.1111/j.1432-1033.2004.04399.x Rabaptin-5 is an effector for the small GTPase Rab5, a regulator of the early steps in endocytosis. In...

Ngày tải lên: 16/03/2014, 18:20

... FEBS Cdk2 activity is dispensable for triggering replicon initiation after transient hypoxia in T24 cells Dirk Stabenow, Hans Probst and Maria van Betteraey-Nikoleit Interfakulta ă res Institut ... Microinjection of antibodies against Cdk2, cyclin E or cyclin A and the antisense mRNA of Cdk2 block initiation of DNA synthesis in mammalian cells [19,20]....

Ngày tải lên: 16/03/2014, 23:20

... complexes consist of integrin proteins, the tyrosine kinases Src and focal adhesion kinase (FAK), actin-binding structural proteins, and the adaptor proteins paxillin and Crk-associated substrate (p130 Cas ) ... that lovastatin induces apoptosis in spontane- ously immortalized rat brain neuroblasts. Focal adhesion proteins and pro- tein kinase Cd (PKCd) hav...

Ngày tải lên: 23/03/2014, 11:20

... al. Aggregation of a-synuclein in yeast cells FEBS Journal 272 (2005) 13861400 ê 2005 FEBS 1397 Characterization of a-synuclein aggregation and synergistic toxicity with protein tau in yeast Piotr ... aspects of a-synuclein aggrega- tion and cytotoxicity, and offer great potential for defining the underlying mechanisms of toxicity and synergist...

Ngày tải lên: 23/03/2014, 13:20

... FEBS MINIREVIEW Cytoskeleton -modulating effectors of enteropathogenic and enterohemorrhagic Escherichia coli: role of EspL2 in adherence and an alternative pathway for modulating cytoskeleton through ... Coprecipita- tion of Annexin A2 with EspL2 from a purified mix- ture of the two in vivo supported the interaction of both proteins and...

Ngày tải lên: 29/03/2014, 09:20

... 1 of 8 (page number not for citation purposes) Journal of Neuroinflammation Open Access Research Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid β-protein in cerebrovascular ... pathology within the cerebral vessel wall, we determined the effects of dexamethasone and two non- steroidal anti-inflammatory drugs (NSAIDs), ibu...

Ngày tải lên: 19/06/2014, 22:20

... phosphor- ylation and activation of protein kinase B (PKB /Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinase- independent signaling by FSH in granulosa cells. Mol Endocrinol 2000, ... 24 h, and 48 h), and phospho -Akt and total -Akt content were examined using Western blotting. Experiment 2 To examine whether Akt activity is involved in...

Ngày tải lên: 20/06/2014, 07:20

... et al.: Antiproliferative factor decreases Akt phosphorylation and alters gene expression via CKAP4 in T24 bladder carcinoma cells. Journal of Experi mental & Clinical Cancer Research 20 ... nM), indicating the importance of this receptor for mediating APF antiproliferative activity in T24 bladder carcinoma cells. APF increases p53 tumor suppressor gen...

Ngày tải lên: 10/08/2014, 10:20