... harbo uring the chitinase 3-like 1(CHI 3L1) gene encoding the YKL-40 protein [6]. YKL-40 is a 40 kDa heparin- and chitin-binding glycoprotein, and a member of chitinase like proteins. YKL-40 ... healthy subjects, and YKL-40 has been suggested to be an auto-antigen and may play a role in development of RA and in inflammation.Methods: Eight SNPs in the CHI3L1 gene and promotor were genotyped ... of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling and injury. Ann Rev Physiol 2011,73:479-501.33. Faibish M, Francescone R, Bentley B, Yan W, Shao R: A YKL-40-neutralizingantibody...