Báo cáo y học: "BACE-1 inhibition prevents the g-secretase inhibitor evoked Ab rise in human neuroblastoma SH-SY5Y cells" ppsx
Báo cáo y học: "BACE-1 inhibition prevents the g-secretase inhibitor evoked Ab rise in human neuroblastoma SH-SY5Y cells" ppsx
... combining BACE and g-
secretase inhibitors.
Materials and met hods
Inhibitors
The g-secretase inhibitor (N)-((S)-2-hydroxy-3-methyl-
butyryl)-1-(L-alaninyl)-(S)-amino -3-methyl-2,3,4,5-tetra-
hydro-1H-3-benzaze ... concentration of inhibi-
tor (leading to substrate accumulation) or not.
Effect of concomitant BACE-1 inhibition on the Ab rise
evoked by LY450139
In SH-SY 5Y AP...
Báo cáo Y học: Group IID heparin-binding secretory phospholipase A2 is expressed in human colon carcinoma cells and human mast cells and up-regulated in mouse inflammatory tissues doc
... surfaces. In the former situation, the
glycosylphosphatidylinositol-anchored HSPG glypican
supports the arachidonic acid-releasing function of the
HSPG-binding sPLA
2
s by sorting them into particular
caveolin-rich ... of type IIA
secretory phospholipase A
2
with the glycosyl phosphatidylinosi-
tol-anchored heparan sulfate proteoglycan in the cyclooxygenase-
2-mediated delayed...
Báo cáo Y học: Functional reconstitution of the HIV receptors CCR5 and CD4 in liposomes pot
... corres-
ponding sites in the polylinker region of the pcDNA3.1-
myc-His expression vector (Invitrogen, Groningen, the
Netherlands) in order to obtain a recombinant protein
containing the C-myc epitope ... glycosaminoglycans [37].
As the myc-his tag of the protein was present at the
C-terminus of the receptor which is located on the inside
of the cell, we then determine...
Báo cáo Y học: Differential regulation of the Fe-hydrogenase during anaerobic adaptation in the green alga Chlamydomonas reinhardtii pot
... stress by redirect-
ing t he synthetic machinery towards the synthesis of s ome
enzymes involved in glycolysis or sugar-phosphate
metabolism [54].
HydA belongs to a new class of Fe-hydrogenases
HydA ... naerobically adapted b y flushing the s olution
withargoninthedark.
Hydrogen evolution assay
Hydrogenase activity of C. reinhardtii was determined
in vitro with reduced methyl viologe...
Báo cáo Y học: NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol Comparison with the Vpr N-terminal (1–51) and C-terminal (52–96) domains pot
... HIV-1
replication, binding of NCp7 to the C-terminal domain
(80–96)Vpr [8] may expose the N-terminal (1–39) portion of
the protein and allow its tight binding to Lys-tRNA
synthetase [15].
The C-terminal domain ... Tyr50 cH Thr55
2.6H Tyr50 a
1
Gly56
3.5H Tyr50 a
1
Gly56
2.6H Tyr50 a
2
Gly56
3.5H Tyr50 a
2
Gly56
2.6H Tyr50 a Ala59
3.5H Tyr50 a Ala59
2.6H Tyr50 b Ala59
3.5H Tyr50 b Ala5...
Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx
... probably
regulated by inhibitory actions of Egr-1 in competition for Sp1
binding sites. Collectively, these data suggest that, in
chondrocytes, alterations in Egr-1 DNA binding activity by
TNF-induced ... were
localized to the extracellular space determined that many of
the protein products of these genes were involved in a variety
of activities, including chemokine/cytokine acti...
Báo cáo y học: "Meeting report on the first Iranian congress of electrodiagnosis in peripheral nerve lesio" potx
... organized by
the Department of Physical Medicine, Rehabilitation and
Electrodiagnosis of Shaheed Beheshti Medical University
in collaboration with the Iranian Society of Physical Med-
icine and Rehabilitation ... Corresponding author
Abstract
The Department of Physical Medicine, Rehabilitation and Electrodiagnosis of Shaheed Beheshti
Medical University in collaboration with the I...
Báo cáo y học: "Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulatio" pps
... and
found an increase in glycosaminoglycan production in load-
bearing areas. On the other hand, there are no human in vivo
studies relating, in the hip joint, the grade of apoptosis with the
biomechanical ... the areas of maximal
and minimal load of the coxofemoral joint.
Competing interests
The authors declare that they have no competing interests.
Authors' cont...
Báo cáo y học: "A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes." ppsx
... merg-
ing the individual lists and removing duplicate genes by
keeping the maximum in absolute value and discarding
the others, yielding 168 genes. The scatter plots were
obtained by plotting the ... Dr
Yaspo; the plasmid containing the cDNA of Runx1 was
obtained from the laboratory of Dr Groner; the plasmid
containing the cDNA of Sim2 was obtained from the lab-
orator...